Patents by Inventor Markus Haberger

Markus Haberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic antibody processing
    Patent number: 8524470
    Abstract: The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment with defined glycostructure comprising the following steps: a) providing an affinity chromatography column eluate containing the immunoglobulin or immunoglobulin fragment, b) incubating the affinity chromatography column eluate with (?1,3)galactosidase of plant origin, e.g. from green coffee beans (EC 3.2.1.22), c) applying the incubated affinity chromatography column eluate to a protein A chromatography material and recovering the immunoglobulin or immunoglobulin fragment from the protein A chromatography material and thereby producing an immunoglobulin or immunoglobulin fragment with defined glycostructure.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: September 3, 2013
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Markus Haberger, Christine Jung, Dietmar Reusch
  • ES-MS OF GLYCOPEPTIDES FOR ANALYSIS OF GLYCOSYLATION
    Publication number: 20120172255
    Abstract: Herein is reported a method for the determination of the glycosylation of an immunoglobulin with electrospray mass spectrometry but without the need for a chromatographic purification step after the digestion of the immunoglobulin and prior to the mass spectrometric analysis.
    Type: Application
    Filed: September 3, 2010
    Publication date: July 5, 2012
    Applicant: HOFFMANN-LA ROCHE, INC,
    Inventors: Markus Haberger, Dietmar Reusch, Maurice Selman, Manfred Wuhrer
  • ENZYMATIC ANTIBODY PROCESSING
    Publication number: 20120129216
    Abstract: The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment with defined glycostructure comprising the following steps: a) providing an affinity chromatography column eluate containing the immunoglobulin or immunoglobulin fragment, b) incubating the affinity chromatography column eluate with (?1,3)galactosidase of plant origin, e.g. from green coffee beans (EC 3.2.1.22), c) applying the incubated affinity chromatography column eluate to a protein A chromatography material and recovering the immunoglobulin or immunoglobulin fragment from the protein A chromatography material and thereby producing an immunoglobulin or immunoglobulin fragment with defined glycostructure.
    Type: Application
    Filed: July 28, 2010
    Publication date: May 24, 2012
    Inventors: Markus Haberger, Christine Jung, Dietmar Reusch
  • Glycosylation Profile Analysis
    Publication number: 20110117601
    Abstract: The present invention provides a method for the production of a glycosylated heterologous polypeptide comprising the steps of obtaining a sample from a crude fermentation broth, incubation of the sample with magnetic affinity beads, releasing glycans from the immobilized glycosylated polypeptides, measuring a glycosylation profile, comparing the glycosylation profile with a desired glycosylation profile of the recombinant glycosylated polypeptide, modifying the culture conditions in accordance to the glycosylation profile obtained, and repeating the process in order to obtain a glycosylated heterologous polypeptide with the desired glycosylation profile. With a similar method diagnostic markers can be identified and quantified.
    Type: Application
    Filed: August 20, 2008
    Publication date: May 19, 2011
    Inventors: Markus Haberger, Dietmar Reusch