Abstract: A turnout for a rail vehicle track system, having a main track and branch track(s) that joins the main track. The main and branch tracks at least in regions have in each case at least two rails, wherein disposed between the sleepers and the ballast bed, on lower sides of sleepers that face the ballast bed, are in each case sleeper pads which each have at least one elastomer layer. The turnout has a turnout frog tip in which the rails of the main track pointing towards the branch track and of the branch track pointing towards the main track converge. A turnout frog region extends from the turnout frog tip in mutually opposite directions and the respective elastomer layers of the respective sleeper pads of the sleepers in the turnout frog region are softer than in regions of the turnout in front of and behind the turnout frog region.

Abstract: The application relates to methods for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method using miRNA, e.g. miR-122 or miR-296-5p, for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.

Abstract: The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.

Abstract: The application relates to methods for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method using miRNA, e.g. miR-122 or miR-296-5p, for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.

Abstract: The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.

Abstract: The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity, and kits for the performance of said determination.

Abstract: The invention relates to a pump for fluid media, more particularly to a cooling water pump for internal combustion engines with an electric motor configured as a disk armature for actuating the pump, said electric motor being directly connected to an impeller (6) of the pump. A simple structure and high operational reliability are achieved in that a driving flange (18) projects radially outward on the outer circumference of the pump's impeller, magnets (19) or windings (20) being molded therein for the contactless drive of the impeller (6).

Abstract: The invention relates to a pump for fluid media, more particularly to a cooling water pump for internal combustion engines with an electric motor configured as a disk armature for actuating the pump, said electric motor being directly connected to an impeller (6) of the pump. A simple structure and high operational reliability are achieved in that a driving flange (18) projects radially outward on the outer circumference of the pump's impeller, magnets (19) or windings (20) being molded therein for the contactless drive of the impeller (6).