Patents by Inventor MARKUS HENDRIKUS VAN ROOSMALEN
MARKUS HENDRIKUS VAN ROOSMALEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230015910Abstract: The invention is based on the finding that incubating a Cryptosporidium gp40 protein with an aziridine, significantly increases its immunogenicity. When used as a vaccine, this allows a reduction of the dose, which improves economic feasibility and safety. Consequently the aziridine-treated gp40 can now be used as a safe and effective subunit-vaccine for humans or non-human-animals against Cryptosporidiosis. Specifically for new-born ruminants a vaccination by way of colostral transfer was found to be very effective in reducing clinical signs of Cryptosporidiosis, especially diarrhoea.Type: ApplicationFiled: December 17, 2020Publication date: January 19, 2023Applicant: Intervet Inc.Inventors: Markus Hendrikus Van Roosmalen, Koen Gevers
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Patent number: 11519923Abstract: A system (1) for detecting an analyte of interest in a sample is disclosed that comprises a measurement chamber (21) for metering the sample and including a defined concentration of an activator (27) causing the generation of a product when interacting with the analyte of interest, a heating element (31) thermally coupled to the measurement chamber, a controller (33) adapted to control the heating element such that the measurement chamber is maintained at a defined temperature (Td), a sensor (35) adapted to detect said product, a timer (37) adapted to time an interaction time between the sample and the activator; and a processor (39) responsive to the sensor and the timer.Type: GrantFiled: June 19, 2017Date of Patent: December 6, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Jeroen Hans Nieuwenhuis, Markus Hendrikus Van Roosmalen, Per Venge
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Patent number: 11519845Abstract: The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.Type: GrantFiled: May 16, 2017Date of Patent: December 6, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Alexander Van Reenen, Markus Hendrikus Van Roosmalen, Hendrik Sibolt Van Damme
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Publication number: 20220165372Abstract: The present invention relates to the means and methods for the detection of bacterial infections, methods discriminating between viral and bacterial infections, methods of stratifying patients for subsequent treatment and further diagnostic purposes and methods to monitor antibiotherapy. The present invention is based on the detection of specific epitopes of human neutrophil lipocalin (HNL) using specific binding agents.Type: ApplicationFiled: February 3, 2022Publication date: May 26, 2022Inventors: MARKUS HENDRIKUS VAN ROOSMALEN, VERONIQUE SEMJONOW, JEROEN HANS NIEUWENHUIS, PER VENGE
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Patent number: 11270782Abstract: The present invention relates to the means and methods for the detection of bacterial infections, methods discriminating between viral and bacterial infections, methods of stratifying patients for subsequent treatment and further diagnostic purposes and methods to monitor antibiotherapy. The present invention is based on the detection of specific epitopes of human neutrophil lipocalin (HNL) using specific binding agents.Type: GrantFiled: November 19, 2015Date of Patent: March 8, 2022Assignee: Koninklijke Philips N.V.Inventors: Markus Hendrikus Van Roosmalen, Veronique Semjonow, Jeroen Hans Nieuwenhuis, Per Venge
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Patent number: 11125744Abstract: The present invention relates to a device (100) for detecting an analyte (12) in a body fluid sample (14) containing a plurality of cells (16). The device (100) comprises a sample input (18) for receiving a body fluid sample (14) containing a plurality of cells (16), and an immunoassay unit (20) comprising a detection surface (28) for performing an immunoassay of said body fluid sample (14) containing a plurality of cells (16). The immunoassay unit (20) comprises an activating reagent (22) for activating the plurality of cells (16) contained in the body fluid sample (14) to release an analyte (12), an anti-analyte-antibody (24) capable of binding to said analyte (12) to form a complex (26) comprising said anti-analyte-antibody (24) and said analyte (12), wherein the forming of said complex (26) proceeds at least partially simultaneous to the activating of said plurality of cells (16).Type: GrantFiled: June 26, 2017Date of Patent: September 21, 2021Assignee: SIEMENS HEALTHINEERS NEDERLAND B.V.Inventors: Markus Hendrikus Van Roosmalen, Jeroen Hans Nieuwenhuis, Per Venge
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Publication number: 20200309675Abstract: The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.Type: ApplicationFiled: May 16, 2017Publication date: October 1, 2020Inventors: Alexander VAN REENEN, Markus Hendrikus VAN ROOSMALEN, Hendrik Sibolt VAN DAMME
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Publication number: 20200217858Abstract: The present invention relates to the use of a derivative of melatonin in an assay, wherein said derivative is a conjugate at position 3 of melatonin's indole ring and wherein said conjugate comprises a linker of at least 2 carbon atoms, with the proviso that the conjugate does not comprise a polypeptide or protein antigen. The derivative preferably comprises 3-(2-ethylamidoglutaric acid)-5-methoxyindole (GUS) and is coupled to a carrier such as dextran. The invention further relates to a method for detecting and/or quantifying melatonin in a sample using a compound comprising said derivative of melatonin, a corresponding immunobiological assay and a kit of parts for detecting and/or quantifying melatonin based on the melatonin derivative.Type: ApplicationFiled: March 16, 2020Publication date: July 9, 2020Inventor: MARKUS HENDRIKUS VAN ROOSMALEN
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Publication number: 20200182894Abstract: A system (1) for detecting an analyte of interest in a sample is disclosed that comprises a measurement chamber (21) for metering the sample and including a defined concentration of an activator (27) causing the generation of a product when interacting with the analyte of interest, a heating element (31) thermally coupled to the measurement chamber, a controller (33) adapted to control the heating element such that the measurement chamber is maintained at a defined temperature (Td), a sensor (35) adapted to detect said product, a timer (37) adapted to time an interaction time between the sample and the activator; and a processor (39) responsive to the sensor and the timer.Type: ApplicationFiled: June 19, 2017Publication date: June 11, 2020Inventors: Jeroen Hans NIEUWENHUIS, Markus Hendrikus VAN ROOSMALEN, Per VENGE
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Publication number: 20190302134Abstract: The disclosure pertains to determining a melatonin level in a biological sample of a subject with a determination system. The determination system comprises a melatonin analyzer, a temperature sensor, and a controller. The method comprises providing a first biological sample from the subject to the melatonin analyzer; generating one or more output signals conveying information related to a temperature of the analyzer; controlling the temperature of the analyzer based on the output signals to be within a pre-determined temperature range, such that responsive to the temperature of the analyzer being outside the pre-determined temperature range, the controlling comprises cooling and/or heating the analyzer to bring and maintain the temperature within the pre-determined temperature range; and responsive to the temperature of the analyzer being within the pre-determined temperature range, facilitating determination of a melatonin level of the first biological sample with the analyzer.Type: ApplicationFiled: March 20, 2019Publication date: October 3, 2019Inventors: LAURENT BROUQUEYRE, MANUEL LAURA LAPOINT, ALEXANDER VAN REENEN, MARKUS HENDRIKUS VAN ROOSMALEN
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Publication number: 20190154671Abstract: The present invention relates to a device (100) for detecting an analyte (12) in a body fluid sample (14) containing a plurality of cells (16). The device (100) comprises a sample input (18) for receiving a body fluid sample (14) containing a plurality of cells (16). and an immunoassay unit (20) comprising a detection surface (28) for performing an immunoassay of said body fluid sample (14) containing a plurality of cells (16). The immunoassay unit (20) comprises an activating reagent (22) for activating the plurality of cells (16) contained in the body fluid sample (14) to release an analyte (12), an anti-analyte- antibody (24) capable of binding to said analyte (12) to form a complex (26) comprising said anti-analyte-antibody (24) and said analyte (12), wherein the forming of said complex (26) proceeds at least partially simultaneous to the activating of said plurality of cells (16).Type: ApplicationFiled: June 26, 2017Publication date: May 23, 2019Inventors: Markus Hendrikus VAN ROOSMALEN, Jeroen Hans NIEUWENHUIS, Per VENGE
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Publication number: 20180372759Abstract: Disclosed is a method for determining onset of a sleep-related analyte. The method includes: obtaining first surrogate measurement(s) of a sleep-related analyte based on signal(s) obtained via sensor(s) during a first time period of observation; obtaining second surrogate measurement(s) of the sleep-related analyte based on signal(s) obtained via sensor(s) during a second time period of observation; determining a first surrogate function or value based on the first surrogate measurement(s) and a second surrogate function or value based on the second surrogate measurement(s); and predicting an onset of the sleep-related analyte for a first individual based on the first surrogate function or value and the second surrogate function or value such that the prediction of the onset of the sleep-related analyte is performed without determining an absolute concentration value for the sleep-related analyte.Type: ApplicationFiled: June 26, 2018Publication date: December 27, 2018Inventors: ALEXANDER VAN REENEN, MARKUS HENDRIKUS VAN ROOSMALEN, LAURENT BROUQUEYRE, PETRUS JOHANNES WILHELMUS VAN LANKVELT
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Publication number: 20170356921Abstract: The present invention relates to the means and methods for the detection of bacterial infections, methods discriminating between viral and bacterial infections, methods of stratifying patients for subsequent treatment and further diagnostic purposes and methods to monitor antibiotherapy. The present invention is based on the detection of specific epitopes of human neutrophil lipocalin (HNL) using specific binding agents.Type: ApplicationFiled: November 19, 2015Publication date: December 14, 2017Applicant: KONINKLIJKE PHILIPS N.V.Inventors: MARKUS HENDRIKUS VAN ROOSMALEN, VERONIQUE SEMJONOW, JEROEN HANS NIEUWENHUIS, PER VENGE
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Publication number: 20170023593Abstract: The present invention relates to the use of a derivative of melatonin in an assay, wherein said derivative is a conjugate at position 3 of melatonin's indole ring and wherein said conjugate comprises a linker of at least 2 carbon atoms, with the proviso that the conjugate does not comprise a polypeptide or protein antigen. The derivative preferably comprises 3-(2-ethylamidoglutaric acid)-5-methoxyindole (GUS) and is coupled to a carrier such as dextran. The invention further relates to a method for detecting and/or quantifying melatonin in a sample using a compound comprising said derivative of melatonin, a corresponding immunobiological assay and a kit of parts for detecting and/or quantifying melatonin based on the melatonin derivative.Type: ApplicationFiled: April 1, 2015Publication date: January 26, 2017Inventor: MARKUS HENDRIKUS VAN ROOSMALEN