Patents by Inventor Markus Heubes

Markus Heubes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof
    Patent number: 11891382
    Abstract: The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula (I) and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula (I) and their use in the treatment of proliferative disorders.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: February 6, 2024
    Inventors: Gregor Welti, Markus Heubes, David Tagliaferri
  • METHODS FOR PURIFYING ISAVUCONAZONIUM SULFATE
    Publication number: 20210323959
    Abstract: The invention provides methods for purifying isavuconazonium sulfate comprising the steps of —(a) providing a mixture comprising the sulfate salt of the compound of formula (I) and an aliphatic alcohol, wherein the pH of the mixture is in the range of about pH 1 to about pH 6; —(b) allowing a first portion of the sulfate salt of the compound of formula (I) to crystalize from the mixture; and —(c) adding an aprotic organic solvent to the mixture and allowing an additional portion of the sulfate salt of the compound of formula (I) to precipitate from the mixture.
    Type: Application
    Filed: July 29, 2019
    Publication date: October 21, 2021
    Inventors: Weipeng ZENG, Marco MAZZOTTI, Lars VICUM, Jeroen CORNEL, Markus HEUBES, Michael SCHLEIMER
  • PROCESSES FOR THE PREPARATION OF FURAZANOBENZIMIDAZOLES AND CRYSTALLINE FORMS THEREOF
    Publication number: 20210115032
    Abstract: The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula (I) and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula (I) and their use in the treatment of proliferative disorders.
    Type: Application
    Filed: April 24, 2018
    Publication date: April 22, 2021
    Inventors: Gregor WELTI, Markus HEUBES, David TAGLIAFERRI
  • Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1?-tert-butoxycarbonyl-2-oxo-[1,3?]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use
    Patent number: 9163034
    Abstract: A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: October 20, 2015
    Assignee: BASILEA PHARMACEUTICA AG
    Inventors: Marco Alpegiani, Jr., Walter Cabri, Markus Heubes, Davide Longoni, Michael Schleimer
  • CRYSTALLINE (6R,7R)-7--3- [(R)-1'-TERT-BUTOXYCARBONYL-2-OXO-[1,3']BIPYRROLIDINYL-(3E)-YLIDENEMETHYL]-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0] OCT-2-ENE-2-CARBOXYLIC ACID BENZHYDRYL ESTER; ITS MANUFACTURE AND USE
    Publication number: 20150005491
    Abstract: A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Applicant: Basilea Pharmaceutica AG
    Inventors: Marco Alpegiani, JR., Walter Cabri, Markus Heubes, Davide Longoni, Michael Schleimer
  • Crystalline (6R,7R)-7-{2-(5-amino-[1,2,4] thiadiazol-3-yl)-2-[(Z)-trityloxyimino]-acetylamino}-3-[(R)-1?-tert-butoxycarbonyl-2-oxo-[1,3?]bipyrrolidinyl-(3E)-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; its manufacture and use
    Patent number: 8865697
    Abstract: A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 21, 2014
    Assignee: Basilea Pharmaceutica AG
    Inventors: Marco Alpegiani, Walter Cabri, Markus Heubes, Davide Longoni, Michael Schleimer
  • Crystalline (6r,7r)-7--3- [(R)-1'-Tert-Butoxycarbonyl-2-Oxo-[1,3']Bipyrrolidinyl-(3e)-Ylidenemethyl]-8-Oxo-5-Thia-1-Aza-Bicyclo[4.2.0] Oct-2-Ene-2-Carboxylic Acid Benzhydryl Ester; Its Manufacture and Use
    Publication number: 20110137026
    Abstract: A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 9, 2011
    Applicant: BASILEA PHARMACEUTICA AG
    Inventors: Marco Alpegiani, Walter Cabri, Markus Heubes, Davide Longoni, Michael Schleimer
  • STABILIZED FREEZE-DRIED FORMULATION FOR CEPHALOSPORIN DERIVATIVES
    Publication number: 20100160278
    Abstract: The present invention relates to a freeze-dried formulation for cephalosporin derivatives having increased stability, a solution for obtaining and a method for preparing such a formulation, as well as the use of certain compounds for stabilizing cephalosporin derivatives in freeze-dried formulations. The compounds preferably used as stabilizers according to the invention are mannitol, trehalose, and PVP.
    Type: Application
    Filed: February 3, 2010
    Publication date: June 24, 2010
    Inventors: Markus Heubes, Wilhelm Scigalla
  • Stabilized Freeze-Dried Formulation for Cephalosporin Derivatives
    Publication number: 20080032962
    Abstract: The present invention relates to a freeze-dried formulation for cephalosporin derivatives having increased stability, a solution for obtaining and a method for preparing such a formulation, as well as the use of certain compounds for stabilizing cephalosporin derivatives in freeze-dried formulations. The compounds preferably used as stabilizers according to the invention are mannitol, trehalose, and PVP.
    Type: Application
    Filed: November 10, 2005
    Publication date: February 7, 2008
    Applicant: Basilea Pharmaceutica AG
    Inventors: Markus Heubes, Wilhelm Scigalla
  • Decalactones, method for making, and pharmaceuticals there from
    Patent number: 6872747
    Abstract: A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the decalactones in pharmaceutical compositions is also described.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: March 29, 2005
    Assignee: Biotecmarin GmbH
    Inventors: Gerhard Bringmann, Peter Prokosch, Ru Angelie Edrada, Markus Heubes, Sudarsono, Eckhard Gunter
  • Decalactones, method for making, and pharmaceuticals there from
    Publication number: 20030216354
    Abstract: A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the decalactones in pharmaceutical compositions is also described.
    Type: Application
    Filed: May 9, 2002
    Publication date: November 20, 2003
    Inventors: Gerhard Bringmann, Peter Proksch, Ru Angelie Edrada, Markus Heubes, Sudarsono, Eckhard Gunther