Patents by Inventor Markus Hornung
Markus Hornung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160023169Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.Type: ApplicationFiled: September 10, 2015Publication date: January 28, 2016Inventors: Bernd Krause, Hermann Göhl, Markus Hornung, Carina Zweigart
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Publication number: 20150367291Abstract: The invention relates to a virus filter membrane which can be used for the removal of virus particles including parvovirus. The invention further relates to a method for producing the membrane. The membrane comprises polyacrylonitrile and polyvinylpyrrolidone.Type: ApplicationFiled: February 24, 2014Publication date: December 24, 2015Inventors: Markus Hornung, Bernd Krause, Johannes Geckeler, Ferdinand Schweiger, Szymon Dutczak, Simon Beiter
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Patent number: 9156005Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.Type: GrantFiled: September 4, 2013Date of Patent: October 13, 2015Assignee: Gambro Lundia ABInventors: Bernd Krause, Hermann Gohl, Markus Hornung, Carina Zweigart
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Publication number: 20150273400Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a prone:is for manufacturing thereof and the use thereof.Type: ApplicationFiled: September 4, 2013Publication date: October 1, 2015Applicant: GAMBRO LUNDIA ABInventors: Bernd KRAUSE, Hermann GOHL, Markus HORNUNG, Carina ZWEIGART
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Publication number: 20150060372Abstract: Porous hollow fiber membranes having a low molecular weight cut-off, processes for their production, and their use for separation tasks in the fields of biotechnology, pharmaceutical technology and food processing.Type: ApplicationFiled: March 4, 2013Publication date: March 5, 2015Applicant: GAMBRO LUNDIA ABInventors: Bernd Krause, Markus Hornung, Johannes Geckeler
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Publication number: 20140326669Abstract: Synthetic membranes for the removal, isolation or purification of substances from a liquid. The membranes include at least one hydrophobic polymer and at least one hydrophilic polymer. 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 ?m are entrapped. The membrane has a wall thickness of below 150 ?m. Methods for preparing the membranes in various geometries, and use of the membranes for the adsorption, isolation and/or purification of substances from a liquid are explored.Type: ApplicationFiled: December 10, 2012Publication date: November 6, 2014Inventors: Ralf Flieg, Markus Storr, Bernd Krause, Markus Hornung, Karl Heinz Klotz
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Publication number: 20140001115Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a prone:is for manufacturing thereof and the use thereof.Type: ApplicationFiled: September 4, 2013Publication date: January 2, 2014Applicant: GAMBRO LUNDIA ABInventors: Bernd KRAUSE, Hermann GOHL, Markus HORNUNG, Carina ZWEIGART
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Patent number: 8596467Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.Type: GrantFiled: October 11, 2007Date of Patent: December 3, 2013Assignee: Gambro Lundia ABInventors: Bernd Krause, Hermann Gohl, Markus Hornung, Carina Zweigart
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Patent number: 8528744Abstract: The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.Type: GrantFiled: September 26, 2008Date of Patent: September 10, 2013Assignee: Gambro Lundia ABInventors: Bernd Krause, Markus Hornung, Silvia Koch, Doris Deppisch
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Publication number: 20120208256Abstract: An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups.Type: ApplicationFiled: October 20, 2010Publication date: August 16, 2012Applicant: GAMBRO LUNDIA ABInventors: Ralf Flieg, Manuela Klotz, Markus Storr, Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Bernd Krause, Markus Hornung
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Patent number: 8051991Abstract: A process for manufacturing of an asymmetric hollow fiber membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fiber spinning nozzle, simultaneously extruding a center fluid through the inner bore of the hollow fiber spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% water the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.Type: GrantFiled: June 25, 2007Date of Patent: November 8, 2011Assignee: Gambro Lundia ABInventors: Bernd Krause, Markus Hornung, Herman Goehl
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Patent number: 7931154Abstract: A process for manufacturing of an asymmetric hollow fiber membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fiber spinning nozzle, simultaneously extruding a center fluid through the inner bore of the hollow fiber spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the center fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water.Type: GrantFiled: June 25, 2007Date of Patent: April 26, 2011Assignee: Gambro Lundia ABInventors: Bernd Krause, Markus Hornung, Herman Goehl
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Publication number: 20110031184Abstract: The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.Type: ApplicationFiled: October 11, 2007Publication date: February 10, 2011Inventors: Bernd Krause, Hermann Gohl, Markus Hornung, Carina Kraft
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Publication number: 20100320146Abstract: The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.Type: ApplicationFiled: September 26, 2008Publication date: December 23, 2010Inventors: Bernd Krause, Markus Hornung, Reinhold Deppisch, Doris Deppisch, Silvia Koch
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Publication number: 20100012577Abstract: A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% w ater the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.Type: ApplicationFiled: June 25, 2007Publication date: January 21, 2010Inventors: Bernd Krause, Markus Hornung, Herman Goehl
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Publication number: 20090283470Abstract: A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the centre fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water.Type: ApplicationFiled: June 25, 2007Publication date: November 19, 2009Inventors: Bernd Krause, Markus Hornung, Herman Goehl
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Publication number: 20090120233Abstract: A control for a vehicle, has at least one activatable momentary contact, controlling and/or switching element for actuating motor-vehicle-internal functions. The control is arranged on the handbrake lever of a manually activated handbrake of the vehicle.Type: ApplicationFiled: April 11, 2006Publication date: May 14, 2009Applicant: Daimler AGInventor: Markus Hornung
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Publication number: 20090057225Abstract: The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges.Type: ApplicationFiled: April 6, 2006Publication date: March 5, 2009Inventors: Bernd Krause, Markus Hornung, Thomas Ertl, Markus Storr