Patents by Inventor Markus Horvath

Markus Horvath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11891624
    Abstract: Herein is reported a method for producing a thymocyte supernatant comprising the steps of co-cultivating thymocytes and mononuclear cells at a cell ratio of at least 0.5:1.2 in the presence of phorbol-12-myristate-13-acetate and Phytohemagglutinin M for up to 60 hours, and separating the co-cultivation medium from the cells and thereby producing the thymocyte supernatant.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: February 6, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Sonja Offner, Markus Horvath, Ingried Saam
  • Patent number: 11097090
    Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: August 24, 2021
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Nikolay V. Vasilyev, Pedro J. del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath
  • Publication number: 20200165566
    Abstract: Herein is reported a method for producing a thymocyte supernatant comprising the steps of co-cultivating thymocytes and mononuclear cells at a cell ratio of at least 0.5:1.2 in the presence of phorbol-12-myristate-13-acetate and Phytohemagglutinin M for up to 60 hours, and separating the co-cultivation medium from the cells and thereby producing the thymocyte supernatant.
    Type: Application
    Filed: October 2, 2019
    Publication date: May 28, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Sonja OFFNER, Markus Horvath, Ingried Saam
  • Publication number: 20180318484
    Abstract: Methods and apparatuses relate to an implantable device for providing contractile assistance to an organ. The device may include an actuator and anchors located on either side of the actuator. The anchors engage with oppositely positioned tissue walls of an organ chamber, and provide contractile assistance to the organ, repeatedly, at appropriate times. For example, the device may be implanted within the right ventricle, anchored to the right ventricular free wall and the ventricular septum. The device may function to bring the opposing walls of the ventricle toward one another, synchronized with the pacing of the heart, resulting in an improved ejection fraction of blood from the chamber. In some embodiments, the actuator includes a bladder that is configured to contract upon receiving an inflow of pressurized fluid therein. When the fluid exits therefrom, the bladder relaxes back to an initial, extended state.
    Type: Application
    Filed: March 28, 2018
    Publication date: November 8, 2018
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Nikolay V. Vasilyev, Pedro J. Del Nido, Tonatiuh M. Lievano Beltran, Erik A. Kraus, Nikhil Mehandru, Evelyn J. Park, Conor J. Walsh, Isaac Wamala, Markus Horvath