Patents by Inventor Markus Hossbach

Markus Hossbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA TARGETED TO BETA CATENIN
    Publication number: 20150291956
    Abstract: A double stranded RNA (dsRNA) molecule targeted to beta catenin includes a duplex region having a sense region and an antisense region at least substantially complementary to the sense region. The sense region and the antisense region each have between 18 and 30 nucleotides. The antisense region includes a nucleotide sequence that is fully complementary to at least 15 contiguous nucleotides of any one of SEQ ID NOs: 1-24.
    Type: Application
    Filed: February 19, 2013
    Publication date: October 15, 2015
    Applicant: PHASERX, INC.
    Inventors: Markus Hossbach, Jochen Deckert
  • Compositions and Methods for Inhibiting Expression of RRM2 Genes
    Publication number: 20150113670
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: John Frederick Boylan, Birgit Bramlage, Markus Hossbach, John Reidhaar-Olson
  • Compositions and methods for inhibiting expression of RRM2 genes
    Patent number: 8946176
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: February 3, 2015
    Assignee: Arrowhead Research Corporation
    Inventors: John Frederick Boylan, Birgit Bramlage, Markus Hossbach, John Reidhaar-Olson
  • Compositions and methods for inhibiting gene expression of hepatitis B virus
    Patent number: 8809293
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Hepatitis B Virus infection using said pharmaceutical composition; and methods for inhibiting the expression of a Hepatitis B Virus gene in a cell.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: August 19, 2014
    Assignee: Arrowhead Madison Inc.
    Inventors: Daniel Chin, Jochen Deckert, Markus Hossbach, Matthias John
  • Compositions and Methods for Inhibiting Gene Expression of Hepatitis B Virus
    Publication number: 20130005793
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Hepatitis B Virus infection using said pharmaceutical composition; and methods for inhibiting the expression of a Hepatitis B Virus gene in a cell.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 3, 2013
    Applicant: ARROWHEAD RESEARCH CORPORATION
    Inventors: Daniel J. Chin, Jochen Deckert, Markus Hossbach, Matthias John
  • Compositions and Methods for Inhibiting Expression of RRM2 Genes
    Publication number: 20120159657
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.
    Type: Application
    Filed: October 18, 2011
    Publication date: June 21, 2012
    Inventors: John Frederick Boylan, Birgit Bramlage, Markus Hossbach, John Reidhaar-Olson
  • Compositions and Methods for Inhibiting Expression of IKK2 Genes
    Publication number: 20110196016
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an IKK2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an IKK2 gene using said pharmaceutical composition; and methods for inhibiting the expression of IKK2 in a cell.
    Type: Application
    Filed: February 1, 2011
    Publication date: August 11, 2011
    Inventors: Anke Geick, Markus Hossbach, Grace Ju, Ingo Roehl
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF IL-18 GENES
    Publication number: 20110152349
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a IL-18 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a IL-18 gene using said pharmaceutical composition; and methods for inhibiting the expression of IL-18 in a cell.
    Type: Application
    Filed: December 14, 2010
    Publication date: June 23, 2011
    Inventors: Anke Geick, Markus Hossbach, Grace Ju, Ingo Roehl
  • Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes
    Publication number: 20110119781
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a TGF-beta receptor type I gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length and which is substantially complementary to at least a part of a TGF-beta receptor type I gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a TGF-beta receptor type I gene using said pharmaceutical composition; and methods for inhibiting the expression of a TGF-beta receptor type I gene in a cell.
    Type: Application
    Filed: July 8, 2009
    Publication date: May 19, 2011
    Inventors: Birgit Bramlage, Markus Hossbach, Pamela Tan, Hans-Peter Vamlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KIF10 GENES
    Publication number: 20110112176
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a KIF10 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a KIF10 gene using said pharmaceutical composition; and methods for inhibiting the expression of KIF10 in a cell.
    Type: Application
    Filed: November 5, 2010
    Publication date: May 12, 2011
    Inventors: John Frederick Boylan, Birgit Bramlage, Wei He, Markus Hossbach, Ingo Roehl
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF GLUCOCORTICOID RECEPTOR (GCR) GENES
    Publication number: 20110020300
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a GCR gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a GCR gene using said pharmaceutical composition; and methods for inhibiting the expression of GCR in a cell.
    Type: Application
    Filed: May 14, 2010
    Publication date: January 27, 2011
    Applicant: GENENTECH, INC.
    Inventors: JACQUES BAILLY, AGNÈS BÉNARDEAU, BIRGIT BRAMLAGE, RAINER CONSTIEN, ANDREA FORST, MARKUS HOSSBACH, BRIGITTE SCHOTT
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF PTP1B GENES
    Publication number: 20100197773
    Abstract: This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a PTP1B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a PTP1B gene using said pharmaceutical composition; and methods for inhibiting the expression of PTP1B in a cell.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 5, 2010
    Inventors: Birgit Bramlage, Rainer Constien, Andrea Forst, Markus Hossbach, John Reidhaar-Olson, Cristina Martha Rondinone, Hans-Peter Vornlocher
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENES
    Publication number: 20100124547
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Factor VII gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a Factor VII gene using said pharmaceutical composition; and methods for inhibiting the expression of Factor VII in a cell.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 20, 2010
    Inventors: Birgit Bramlage, Rainer Constien, Jacques Himber, Markus Hossbach, Pamela Tan, Hans-Peter Vornlocher