Abstract: Method for operating a bioprocess installation for production of a bioproduct, wherein the bioprocess installation comprises a source receptacle for cell cultivation, a harvest receptacle for bioproduction and a clarification setup with a centrifuge wherein the source receptacle is operated in a cyclical production mode comprising the steps of: a) starting the cyclical production mode, b) cultivating the cells thereby obtaining a cell broth comprising cultivated cells, c) discharging a discharge fraction of the cell broth, d) combining a restart fraction of the cell broth with fresh cultivation medium and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth obtained from step d), obtaining a discharge fraction, wherein the method further comprises the steps: i) centrifuging the discharge fraction via the centrifuge, ii) operating the harvest receptacle in a production mode, wherein steps i) and ii) are executed at least twice.

Abstract: Instruments and associated methods are generally provided. Advantageously, some instruments described herein may be capable of and/or configured to detect a concentration of an analyte in a fluid that is flowing, in a fluid that includes a high concentration of an analyte, and/or in multiple fluids and/or samples of a fluid in rapid succession. Some methods may comprise detecting a concentration of an analyte that is advantageous for one or more of the aforementioned reasons.

Abstract: A separation system and methods for separating and purifying a target component include a separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a single-pass crossflow diafiltration unit for integrally connecting a first and a second chromatography device.

Abstract: Various embodiments provide a method for producing a bioproduct using a bioprocess installation. The bioprocess installation comprises an process control and a bioprocess unit. The bioprocess unit comprises a receptacle, a clarification unit with a centrifuge and a chromatography unit with a chromatograph. Cell broth obtained from the receptacle is lead through the clarification unit and the chromatography unit in a liquid stream. The clarification unit with its centrifuge is being operated in a centrifugation cycle comprising centrifugation steps. The chromatography unit with its chromatograph is being operated in a chromatography cycle comprising chromatography steps.

Abstract: A separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a crossflow diafiltration unit for processing a target phase. The system includes an aqueous-two phase extraction unit for aqueous-two phase extraction of the fluid, a separation unit for separating a target phase, and a crossflow diafiltration unit.

Abstract: A method for operating a bioprocess installation with an electronic process control and at least one bioprocess unit, wherein the bioprocess unit comprises a cell broth source with a first receptacle for cell broth including cultivation media and cells, establishing a culture environment for cell cultivation and/or bio production, wherein the bioprocess unit comprises a clarification setup with a centrifuge for the clarification of the cell broth by centrifugation, with a liquid pumping arrangement assigned to the centrifuge and with a liquid network with a number of liquid lines communicating with the liquid pumping arrangement, wherein out of a first culture environment established by the first receptacle, the cell broth is transfered to the centrifuge via the liquid network, which centrifuge is operated in a forward operation for cell separation and/or cell washing and in a backward operation for cell discharging.

Abstract: A computer-implemented method can configure and/or setup and/or control a downstream process for processing a biomass, including receiving at least one measurement value of at least one feature of an upstream process by which the biomass to be processed in the downstream process has been obtained and/or of at least one feature of a downstream process stage or operation, determining at least one downstream process parameter based on the received at least one measurement value, arid configuring and/or setup and/or controlling at least one downstream process stage or process operation based on the determined at least one downstream process parameter.

Abstract: A clarification setup of a bioprocessing installation wherein, for the centrifugation, the clarification setup comprises a centrifuge, wherein the centrifuge comprises at least one centrifuge chamber with a chamber inlet and a chamber outlet, wherein the clarification setup comprises a liquid pumping arrangement assigned to the centrifuge and a liquid network with a number of liquid lines communicating with the liquid pumping arrangement, wherein the clarification setup comprises a process control for controlling the centrifuge and the liquid pumping arrangement. For filtration, the clarification setup comprises a filter arrangement, that the liquid network provides an outlet supernatant line for a liquid connection between the chamber outlet and the filter arrangement, which is at least temporarily liquid-tight, such that due to this liquid-tight condition of the outlet supernatant line the liquid pumping arrangement as such may drive the supernatant from the chamber outlet to the filter arrangement.

Abstract: Fluidic modules configured for flowing fluid through membranes and associated methods are generally provided. In some embodiments, a fluidic module comprises two channels between which a membrane is positioned. The two channels may have geometries such that the pressure drop experienced by a fluid flowing from the first channel, through the membrane, and into the second channel is substantially independent of the location along the channel at which it flows through the membrane. In other words, the pressure drop may be substantially constant over the membrane area.

Abstract: Systems and methods of controlling transmissions of a media stream are provided. In one exemplary embodiment, a method performed by a media client for controlling a transmission of a media stream from a media server to the media client may include obtaining a media description of the media stream. The media description may indicate an initial stream element of the consecutive stream elements. Further, the method may include sending a request for the initial stream element. In addition, the method may include requesting, towards a control entity for a session, an establishment of the session or a modification of the session, for associating the media stream with the session. After sending the request for the initial stream element, the method may include receiving a result of the session establishment or session modification request.

Abstract: Systems and methods of controlling transmissions of a media stream are provided. In one exemplary embodiment, a method performed by a media client for controlling a transmission of a media stream from a media server to the media client may include obtaining a media description of the media stream. The media description may indicate an initial stream element of the consecutive stream elements. Further, the method may include sending a request for the initial stream element. In addition, the method may include requesting, towards a control entity for a session, an establishment of the session or a modification of the session, for associating the media stream with the session. After sending the request for the initial stream element, the method may include receiving a result of the session establishment or session modification request.

Abstract: Systems and methods of controlling transmissions of a media stream are provided. In one exemplary embodiment, a method performed by a media client for controlling a transmission of a media stream from a media server to the media client may include obtaining a media description of the media stream. The media description may indicate an initial stream element of the consecutive stream elements. Further, the method may include sending a request for the initial stream element. In addition, the method may include requesting, towards a control entity for a session, an establishment of the session or a modification of the session, for associating the media stream with the session. After sending the request for the initial stream element, the method may include receiving a result of the session establishment or session modification request.

Abstract: To control content delivery to plural clients of a mobile communication network, a network entity of the mobile communication network collects geo information of the plural clients and evaluates the collected geo information of the plural clients based on a rule to determine whether the content delivery is to be adapted. The network entity identifies a region for which the content delivery is to be adapted. The network entity selectively outputs a message to a controlling entity if it is determined that the content delivery is to be adapted. The controlling entity controls the content delivery in response to receiving the message, to adapt the content delivery for clients located in the identified region.

Abstract: Methods and devices for providing a media description of a media stream to a client are described. The client is subscribed to a media description delivery service. The media description delivery service comprises a media description delivery rule. A request for a media description delivery is sent to a media server. From the media server a media description is received. It is verified that the received media description complies with the media description delivery rule and if the verification is in the affirmative, a delivery of the media description is initiated to the client.

Abstract: Methods and devices for providing a media description of a media stream to a client are described. The client is subscribed to a media description delivery service. The media description delivery service comprises a media description delivery rule. A request for a media description delivery is sent to a media server. From the media server a media description is received. It is verified that the received media description complies with the media description delivery rule and if the verification is in the affirmative, a delivery of the media description is initiated to the client.

Abstract: A technique for registering a device (10) with a rights issuer system (12) in a digital rights management (DRM) context is described. The device (10) is provided with DRM registration information that is required to use protected content. The DRM registration information is generated from rights issuer information on the one hand and device information on the other hand. The DRM registration technique described herein does not require an interactive registration protocol between a rights issuer server (12) and the device (10). Rather, the DRM registration information may be generated and transferred to the device (10) even if the device (10) is offline, inactive or switched-off.

Abstract: Methods and devices for providing a media description of a media stream to a client are described. The client is subscribed to a media description delivery service. The media description delivery service comprises a media description delivery rule. A request for a media description delivery is sent to a media server. From the media server a media description is received. It is verified that the received media description complies with the media description delivery rule and if the verification is in the affirmative, a delivery of the media description is initiated to the client.

Abstract: To control content delivery to plural clients of a mobile communication network, a network entity of the mobile communication network collects geo information of the plural clients and evaluates the collected geo information of the plural clients based on a rule to determine whether the content delivery is to be adapted. The network entity identifies a region for which the content delivery is to be adapted. The network entity selectively outputs a message to a controlling entity if it is determined that the content delivery is to be adapted. The controlling entity controls the content delivery in response to receiving the message, to adapt the content delivery for clients located in the identified region.

Abstract: To control content delivery to plural clients (6) of a mobile communication network (1), a network entity (5) of the mobile communication network (1) collects geo information of the plural clients (6) and evaluates the collected geo information of the plural clients (6) based on a rule to determine whether the content delivery is to be adapted. The network entity (5) identifies a region for which the content delivery is to be adapted. The network entity (5) selectively outputs a message (9) to a controlling entity (10) if it is determined that the content delivery is to be adapted. The controlling entity (10) controls the content delivery in response to receiving the message (9), to adapt the content delivery for clients located in the identified region.

Abstract: Systems and methods of controlling transmissions of a media stream are provided. In one exemplary embodiment, a method performed by a media client for controlling a transmission of a media stream from a media server to the media client may include obtaining a media description of the media stream. The media description may indicate an initial stream element of the consecutive stream elements. Further, the method may include sending a request for the initial stream element. In addition, the method may include requesting, towards a control entity for a session, an establishment of the session or a modification of the session, for associating the media stream with the session. After sending the request for the initial stream element, the method may include receiving a result of the session establishment or session modification request.