Abstract: The present invention relates to medical uses comprising the administration of anti-human CCR8 antibodies in specifically defined dosage regimens in monotherapy or combination therapy with an anti-PD-(L)1 antibody. The dosing schemes were developed for anti-human/cynomolgus CCR8 antibody TPP-23411, but they can also be used for other antibodies having similar properties as TPP-23411. The medical uses or dosage regimens may comprise a stratification step to select patients with an increased probability of treatment success. Suggested biomarkers are a) Tumor Proportion Score or Combined Positive Score as a measure for PD-(L)1 expression, b) analysing in a blood, plasma or serum sample inflammatory cytokines and c) previous treatment of the cancer for at least 6 months with an anti-PD-(L)1 antibody.

Abstract: A computed tomography device includes a slipring for rotational transmission and a feed line. The slipring is arranged to be rotatable relative to the feed line. Two sliding contact elements are further included, forming sliding contacts between a slideway of the slipring and the feed line, the two sliding contacts being connected in parallel with one another and electrically conductively connected together via at least one portion of the slideway and via at least one portion of the feed line. Finally, the computed tomography device includes a measuring apparatus, configured to acquire a measured value dependent on a resultant inductance between the two sliding contact elements; and at least one processor, configured to determine an operating state of the two sliding contacts based upon the measured value.

Abstract: A computed tomography device includes a slipring for rotational transmission and a feed line. The slipring is arranged to be rotatable relative to the feed line. Two sliding contact elements are further included, forming sliding contacts between a slideway of the slipring and the feed line, the two sliding contacts being connected in parallel with one another and electrically conductively connected together via at least one portion of the slideway and via at least one portion of the feed line. Finally, the computed tomography device includes a measuring apparatus, configured to acquire a measured value dependent on a resultant inductance between the two sliding contact elements; and at least one processor, configured to determine an operating state of the two sliding contacts based upon the measured value.

Abstract: The fall arrester (10) is part of a climbing protection system for preventing a user of a ladder, a platform or the like from falling. The fall arrester (10) is movable along a guide rail (12) and has a rotatably mounted pawl (18) which, in the event of a fall, runs against catching stops (16) in the guide rail (12). A connecting element (40) is attached to the pawl (18) and the user can be secured to the connecting element (40) by a lanyard. The connecting element (40) is hinged to the pawl (18). The connecting element (40) can be hinged to the pawl (18) such that the connecting element (40) is coupled releasably rotation-resistant to the pawl (18) and the coupling (50, 52) is released in the event of a predetermined force on the connecting element (40). The connecting element can be formed as a damping element (40) which deforms in the event of a predetermined force.

Abstract: The invention relates to an apparatus and a method for starting an internal combustion engine for a motor vehicle, wherein the internal combustion engine has an associated electrical machine (1) which is operated as a starter/generator. During starting, the electrical machine (1) is supplied with a voltage which is obtained from addition or from subtraction of the voltages which are produced on a first energy store (3) and the voltages which are produced on a second energy store (4).

Abstract: The fall arrester (10) is part of a climbing protection system for preventing a user of a ladder, a platform or the like from falling. The fall arrester (10) is movable along a guide rail (12) and has a rotatably mounted pawl (18) which, in the event of a fall, runs against catching stops (16) in the guide rail (12). A connecting element (40) is attached to the pawl (18) and the user can be secured to the connecting element (40) by a lanyard. The connecting element (40) is hinged to the pawl (18). The connecting element (40) can be hinged to the pawl (18) such that the connecting element (40) is coupled releasably rotation-resistant to the pawl (18) and the coupling (50, 52) is released in the event of a predetermined force on the connecting element (40). The connecting element can be formed as a damping element (40) which deforms in the event of a predetermined force.

Abstract: The invention relates to an apparatus and a method for starting an internal combustion engine for a motor vehicle, wherein the internal combustion engine has an associated electrical machine (1) which is operated as a starter/generator. During starting, the electrical machine (1) is supplied with a voltage which is obtained from addition or from subtraction of the voltages which are produced on a first energy store (3) and the voltages which are produced on a second energy store (4).

Abstract: A catch device, as part of a fall protection for ladders and similar climbing devices, for application in a guide rail with a C-profile, includes a body and at least two pairs of rollers, arranged in the body so as to run inside the guide rail. At least one pair of rollers is rigidly fixed to the body and one roller pair is arranged to pivot about an axis at right angles to the longitudinal axis of the guide rail and which runs up to the rotational axis of the roller pair. The pivoting roller pair can be fixed in a secure position such that the pivoting roller pair is fixed on a shaft, mounted so as to rotate in the body, the upper end of the shaft projecting from the body and having an indent. A hanging latch is connected to the body which may engage in the indent. The hanging latch can be locked in the engaged position.

Abstract: A circuit is provided for an alternator of a motor vehicle with the winding of the alternator consisting of two half-windings, with rectification of the voltages and currents at the outputs of the two half-windings taking place, with the outputs of one half-winding being connected with the inputs of a first rectifier, and with the outputs of the other half-winding being connected with the inputs of another rectifier, and with each output of one half-winding being connectable across the gaps of two switchable elements with two outputs of the other half-winding in each case such that when the gaps are bridged, the two half-windings are connected electrically in series. In a method for triggering the switchable elements, the individual thyristors are triggered in succession and/or only individual transistors are triggered, with this preferably taking place when a certain motor rpm is undershot. Diodes c an also be used instead of individual thyristors.