Patents by Inventor Markus Krumme

Markus Krumme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11045387
    Abstract: A single-dose package for transdermal therapeutic systems or film-shaped administration forms, in the form of a tear-open sealed-edge pouch with a completely surrounding and continuous non-peelable sealing surface. The single-dose packages are provided with two packaging material elements, which are arranged one lying on top of the other and form the upper side and underside of a pouch that contains the product. At least one packaging material element is a tear-resistant film laminate with an at least three-layer structure, wherein at least one layer of the packaging material elements is a metal layer. The single-dose package also has a linear weakening, which lies in the sealing area, does not touch the edge of the package and extends in the direction of the weaker tear resistance of the upper side and underside and the linear form of the anisotropically tear-resistant plastic.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: June 29, 2021
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Markus Krumme
  • Publication number: 20210148634
    Abstract: The invention relates to a drying device for drying a product comprising: a housing having a drying chamber, a product inlet at a first end and an product outlet at a second end; a drying rotor arranged rotatable within the drying chamber and having at least one helical groove at the outer surface thereof; a screw having a flight with a flight channel there between and arranged rotatable within the drying chamber and substantially parallel to the drying rotor; a driving mechanism configured for driving the screw in rotation around a screw axis; and a heater for providing thermal energy to the drying chamber, wherein the drying rotor and/or the screw at least are configured for moving the product from the first end to the second end, and such that the flight of the screw engages into the at least one helical groove of the drying rotor.
    Type: Application
    Filed: April 10, 2019
    Publication date: May 20, 2021
    Inventors: Peter Gerardus Josephus VAN DER WEL, Albert KAPTEIN, Markus KRUMME, Thomas Karl Michael MANNSCHOTT, Isabella Patrizia AIGNER, Manuel Philipp ZETTL, Manuel KREIMER
  • Publication number: 20210069114
    Abstract: A method for preparing granules a slurry containing solid API powder particles dispersed in a liquid is prepared. The slurry is fed to a granulator and mixed with a dry base powder within the granulator in order to produce a slurry/base powder mixture. The slurry/base powder mixture produced within the granulator is dried in order to obtain granules containing the solid API particles and the base powder.
    Type: Application
    Filed: August 30, 2018
    Publication date: March 11, 2021
    Inventors: Markus KRUMME, Hans DE WAARD, Klaus-Peter MOLL, Adrian ACHMIDT, Julien TAILLEMITE
  • Patent number: 10806703
    Abstract: The present invention relates to a transmucosal administration system to administer quinones, benzoquinones, and especially 1,4-benzoquinones, via the oromucosal route.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: October 20, 2020
    Assignees: LTS Lohmann Therapie-System AG, Santhera Pharmaceuticals (Schweitz) AG
    Inventors: Markus Krumme, Keith Jensen, Judith Dubach-Powell, Rudolf Hausmann
  • Publication number: 20200315973
    Abstract: A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.
    Type: Application
    Filed: September 28, 2018
    Publication date: October 8, 2020
    Inventors: Elodia Di Renzo, David Hook, Markus Krumme, Steffen Lang, Massimo Moratto, Joerg Ogorka, Jim Parks, Dale Ploeger, Norbert Rasenack, Hendrik Schneider, Stefan Steigmiller, Gordon Stout, Patrick Tritschler, Fabian Weber
  • Publication number: 20200306198
    Abstract: A formulation for injection molding of a pharmaceutical carrier comprises 43.5-97% (w/w) of one or more polyethylene oxide polymer having a weight average molecular weight of MW 94,000-188,000; and optionally one or more excipients.
    Type: Application
    Filed: September 28, 2018
    Publication date: October 1, 2020
    Inventors: Florian Beck, Hans de Waard, Sarah Gold, Stefan Hirsch, David Hook, Nikhil Kavimandan, Markus Krumme, Steffen Lang, Detlef Moll, Siddharthya Mujumdar, Anh-Thu Nguyen-Trung, Joerg Ogorka, Norbert Rasenack, Raphael Tobler, Patrick Tritschler
  • Patent number: 10744176
    Abstract: An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: August 18, 2020
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Publication number: 20200246272
    Abstract: A pharmaceutical carrier (20) comprises a lid part (22) and a bottom part (24), wherein at least one of the lid part (22) and the bottom part (24) has a first wall section (26, 30) with a thickness of 180-250 ?m, preferably 185-225 ?m, even more preferably 190-220 ?m, and most preferably about 215 ?m, and a second wall section (28, 32) with a thickness of 350-450 ?m, preferably 375-425 ?m, more preferably 390-410 ?m, and most preferably about 400 ?m. The first wall section (26) of the lid part (22) defines an entire top portion of the lid part (22). Alternatively or additionally thereto, the first wall section (30) of the bottom part (24) defines an entire bottom portion of the bottom part (24).
    Type: Application
    Filed: September 28, 2018
    Publication date: August 6, 2020
    Inventors: Florian Beck, Hans de Waard, Sarah Gold, Stefan Hirsch, David Hook, Nikhil Kavimandan, Markus Krumme, Steffen Lang, Detlef Moll, Siddharthya Mujumdar, Anh-Thu Nguyen-Trung, Joerg Ogorka, Norbert Rasenack, Raphael Tobler, Patrick Tritschler
  • Patent number: 10716762
    Abstract: The present invention relates to a transmucosal administration system to administer quinones, benzoquinones, and especially 1,4-benzoquinones, via the oromucosal route.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: July 21, 2020
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Markus Krumme, Keith Jensen, Judith Dubach-Powell, Rudolf Hausmann
  • Publication number: 20200222325
    Abstract: In a method for preparing at least partially dried granules, an API, a base powder, and a granulation liquid are fed to a granulator. The API, the base powder and the granulation liquid are mixed within the granulator to produce an API/base powder/granulation liquid mixture. This liquid mixture within the granulator is heated to a heating temperature (TH) that exceeds an evaporation temperature (TE) of the granulation liquid contained in an API/base powder/granulation liquid mixture to allow at least a part of the granulation liquid contained in the API/base powder/granulation liquid mixture to evaporate in order to obtain at least partially dried granules containing at least the API and the base powder. The at least partially dried granules are discharged from the granulator.
    Type: Application
    Filed: August 30, 2018
    Publication date: July 16, 2020
    Inventors: Markus KRUMME, Hans DE WAARD, Klaus-Peter MOLL, Adrian SCHMIDT, Frantz ELBAZ, Peter KLEINEBUDDE
  • Publication number: 20190350872
    Abstract: The invention generally relates to transmucosal administration systems for administering quinones, benzoquinones, and especially 1,4-benzoquinones, via the oromucosal route. The present invention more specifically relates to methods of treatment for Duchenne Muscular Dystrophy that includes administering to a patient a dose in the form of one or more transmucosal administration systems.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 21, 2019
    Inventors: Markus KRUMME, Keith JENSEN, Judith DUBACH-POWELL, Rudolf HAUSMANN
  • Publication number: 20190336554
    Abstract: An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 7, 2019
    Inventors: Michael LI, Markus KRUMME
  • Patent number: 10398746
    Abstract: An edible oral film strip dosage form containing an unpalatable basic active pharmaceutical ingredient and an ion exchange resin as a primary taste masking agent, along with an optional acidic agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: September 3, 2019
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Publication number: 20180185286
    Abstract: Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or dissolution rates for pharmaceutically active species having poor aqueous solubility.
    Type: Application
    Filed: March 31, 2015
    Publication date: July 5, 2018
    Applicants: NOVARTIS PHARMA AG, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Allan Stuart Myerson, Xiaochuan Yang, Marcus O'Mahony, Markus Krumme, Norbert Rasenack, Leia Dwyer
  • Publication number: 20180092979
    Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 5, 2018
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Patent number: 9849184
    Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: December 26, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Publication number: 20170348321
    Abstract: The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 7, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Markus Krumme, Albert Radlmaier, Sescha General, Michael Dittgen, Keith Jensen
  • Patent number: 9763960
    Abstract: The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: September 19, 2017
    Assignee: LTS Lohmann Theraple-Systeme AG
    Inventors: Markus Krumme, Albert Radlmaier, Sascha General, Michael Dittgen, Keith Jensen
  • Publication number: 20170136078
    Abstract: An edible oral film strip dosage form containing an unpalatable basic active pharmaceutical ingredient and an ion exchange resin as a primary taste masking agent, along with an optional acidic agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
    Type: Application
    Filed: January 31, 2017
    Publication date: May 18, 2017
    Inventors: Michael LI, Markus KRUMME
  • Patent number: 9637293
    Abstract: A childproof packaging for individual doses, in particular for preparations for administration in film form, wherein the packaging constitutes a bag produced by sealing, which has a covering layer which is provided at each side of the packaging with local weak points which do not touch the edge of the packaging, wherein the local weak points form a cohesive pattern which runs around the individual dose in an arc or a curve and overlaps an angular region of at least 90° when considered from the main area of the individual zone. The local weak points have a start area and an end area which have a Y configuration when the local weak points on each side of the packaging are superposed.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 2, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Markus Krumme, Grace A. Behrend, Stephen J. Dodd