Patents by Inventor Markus Kunzler

Markus Kunzler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an n-methylated (poly) peptide
    Patent number: 11180738
    Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 23, 2021
    Assignee: ETH ZURICH
    Inventors: Markus Aebi, Markus Kunzler, Jorn Piel, Michael Freeman, Niels Van Der Velden, Noemi Kalin
  • NOVEL MULTIPLY BACKBONE N-METHYL TRANSFERASES AND USES THEREOF
    Publication number: 20190112583
    Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.
    Type: Application
    Filed: April 7, 2017
    Publication date: April 18, 2019
    Inventors: Markus AEBI, Markus KUNZLER, Jorn PIEL, Michael FREEMAN, Niels VAN DER VELDEN, Noemi KALIN
  • N-GLYCAN CORE BETA-GALACTOSYLTRANSFERASE AND USES THEREOF
    Publication number: 20150203828
    Abstract: The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.
    Type: Application
    Filed: February 21, 2014
    Publication date: July 23, 2015
    Applicants: ETH ZURICH, UNIVERSITAT FUR BODENKULTUR WIEN, UNIVERSITAT ZURICH
    Inventors: Markus KÜNZLER, Markus AEBI, Iain WILSON, Alexander Walter TITZ, Micahel HENGARTNER, Alex BUTSCHI
  • MEDICAL UTILITY OF GLYCAN-BINDING PROTEINS AND GLYCANS
    Publication number: 20120207737
    Abstract: The present invention relates to the use of glycan-binding polypeptides and glycans as a medicament, in particular for treating and/or preventing helminthic infections or an immune disease. Moreover, the present invention is directed to corresponding pharmaceutical compositions, food products and animal feed comprising isolated glycans and/or glycan-binding polypeptides. In addition, the present invention teaches methods for identifying anti-helminthic carbohydrate-binding polypeptides, for identifying helminthic glycan and gene targets involved in glycan-mediated toxicity, for identifying helminths susceptible to glycan-mediated toxicity, and for identifying anti-helminthic and anti-allergic substances.
    Type: Application
    Filed: October 12, 2010
    Publication date: August 16, 2012
    Applicants: UNIVERSITY OF ZURICH, ETH ZURICH
    Inventors: Markus Kunzler, Martin Walti, Alex Butschi, Markus Aebi, Michael Hengartner
  • N-GLYCAN CORE BETA-GALACTOSYLTRANSFERASE AND USES THEREOF
    Publication number: 20120064541
    Abstract: The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.
    Type: Application
    Filed: May 28, 2010
    Publication date: March 15, 2012
    Applicants: ETH ZÜRICH, UNIVERSITÄT FÜR BODENKULTUR WIEN, UNIVERSITÄT ZÜRICH
    Inventors: Markus Künzler, Markus Aebi, Lain Wilson, Alexander Walter Titz, Michael Hengartner, Alex Butschi