Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: A pipetting device (1) for receiving and dispensing fluid volumes, comprising a housing (2) with a holding portion (3), which is constructed for holding the pipetting device (1) by means of an operator's hand, a support device (4), which is designed for supporting the pipetting device (1) on an operator's finger, the support device (4) being rotatable relative to the holding portion (3), preferably about a longitudinal axis (L) of the pipetting device (1). The invention further relates to a pipetting device (1) for receiving and dispensing fluid volumes, comprising a releasable positive connection between a first and a second component of the pipetting device (1). Because the support device is adjustable relative to the holding device into a plurality of different defined rotational positions the pipetting device can be used by either left-handed and right-handed operators or by operators with hands of different sizes.

Abstract: A valve block assembly for a bottle attachment apparatus for handling liquids has a valve block, an intake valve insert and/or an exhaust valve insert, and a valve receptacle assigned to the respective valve insert. The valve insert is inserted in a replaceable and sealing manner in the valve receptacle. The valve insert has a stop portion, a fastening portion distinct therefrom and a sealing portion distinct from both. The associated valve receptacle has stop, fastening, and sealing portions matching the equivalent portions of the valve insert. When the valve insert is installed correctly both the stop portions and the sealing portions bear on one another in a planar manner.

Abstract: A pipetting device for taking up and dispensing fluid volumes has a displacement device with a displacement mechanism and a displacement housing. The pipetting device has an adjusting device for changing the stroke of the displacement mechanism. The stroke of the displacement mechanism can be adjusted, and the corresponding adjustment value can be displayed by an adjustment indicator. A coupling device, in a use state, couples the adjusting device to a volume indicator and decoupled the adjustment device from the adjustment indicator. In an adjustment state, the adjusting device is coupled to the adjustment indicator and is decoupled from the volume indicator. The adjustment indicator displays an adjustment value for the stroke of the displacement means. The adjustment indicator can be adjusted in an adjustment state, whereas it is fixed in a use state.

Abstract: A valve block assembly for a bottle attachment apparatus for handling liquids has a valve block, an intake valve insert and/or an exhaust valve insert, and a valve receptacle assigned to the respective valve insert. The valve insert is inserted in a replaceable and sealing manner in the valve receptacle. The valve insert has a stop portion, a fastening portion distinct therefrom and a sealing portion distinct from both. The associated valve receptacle has stop, fastening, and sealing portions matching the equivalent portions of the valve insert. When the valve insert is installed correctly both the stop portions and the sealing portions bear on one another in a planar manner.

Abstract: A pipetting device for taking up and dispensing volumes of fluid, which has an ejector mechanism which is actuable by means of an actuating means to eject or release a pipette tip plugged onto the pipetting device. The pipetting device has a coupling mechanism which is configured such that, in the unactuated state, actuating means and ejector mechanism are decoupled, and, when the actuating means is actuated, the latter is coupled to the ejector mechanism, causing a force exerted on the actuating means to transfer to the ejector mechanism. Also, the pipetting device can have a positioning mechanism which, when a pipette tip is not plugged on and the actuating means is unactuated, holds an ejector means, of the ejector mechanism in a basic position which is located between an ejection position and a plug-on position with a pipette tip plugged on.

Abstract: A valve block assembly for a bottle attachment apparatus for handling liquids has a valve block, an intake valve insert and/or an exhaust valve insert, and a valve receptacle assigned to the respective valve insert. The valve insert is inserted in a replaceable and sealing manner in the valve receptacle. The valve insert has a stop portion, a fastening portion distinct therefrom and a sealing portion distinct from both. The associated valve receptacle has stop, fastening, and sealing portions matching the equivalent portions of the valve insert. When the valve insert is installed correctly both the stop portions and the sealing portions bear on one another in a planar manner.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: An exhaust valve assembly for a bottle attachment apparatus for handling liquids has a valve housing which forms a valve chamber having an inlet and an outlet, an exhaust valve body disposed on the inlet in the valve chamber, and a safety valve body disposed on the outlet in the valve chamber. The exhaust valve body is biased toward an exhaust valve seat, counter to the flow direction of the liquid and the safety valve body is biased toward a safety valve seat in the flow direction of the liquid. The safety valve seat is integrally molded on the valve housing.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: An exhaust valve assembly for a bottle attachment apparatus for handling liquids has a valve housing which forms a valve chamber having an inlet and an outlet, an exhaust valve body disposed on the inlet in the valve chamber, and a safety valve body disposed on the outlet in the valve chamber. The exhaust valve body is biased toward an exhaust valve seat, counter to the flow direction of the liquid and the safety valve body is biased toward a safety valve seat in the flow direction of the liquid. The safety valve seat is integrally molded on the valve housing.

Abstract: An exhaust valve assembly for a bottle attachment apparatus for handling liquids has a valve housing which forms a valve chamber having an inlet and an outlet, an exhaust valve body disposed on the inlet in the valve chamber, and a safety valve body disposed on the outlet in the valve chamber. The exhaust valve body is biased toward an exhaust valve seat, counter to the flow direction of the liquid and the safety valve body is biased toward a safety valve seat in the flow direction of the liquid. The safety valve seat is integrally molded on the valve housing.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: A cylinder-and-piston assembly for a bottle attachment apparatus for handling liquids in which the stroke length of the piston of the cylinder-and-piston assembly is delimited by a stroke length stop when suctioning from the cylinder and is delimited by a readjustment stop when exhausting into the cylinder. The readjustment stop is disposed on the piston or on the cylinder housing and interacts with a fixed stop. The readjustment stop is accessible and adjustable by way of a removable seal. The seal is connected by way of ribs to a piston bearing. The readjustment stop is disposed below this removable seal. The seal has a molding and the piston bearing has a counter molding. Displacement of the seal in relation to the piston bearing moves the seal in the longitudinal direction, and by this movement, the seal is removed in a manner that preferably is not capable of re-assembly.

Abstract: A cylinder-and-piston assembly for a bottle attachment apparatus for handling liquids provides a cylinder attachable to a valve block assembly, a piston, displaceable in a sealed manner in the longitudinal direction within the cylinder, and a cylinder housing connected to the piston and externally encompassing the cylinder. The piston is displaceable in the cylinder and the stroke length of the piston in the cylinder is delimited by a fixed stop, which interacts with a stroke length stop on the cylinder housing. The cylinder housing has a longitudinal slot running in the longitudinal direction and on the external side thereof has a scale assigned to this longitudinal slot. The stroke length stop on the cylinder housing is adjustable in the longitudinal direction and is interlockable in the respective position.

Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

Abstract: A cylinder-and-piston assembly for a bottle attachment apparatus for handling liquids in which the stroke length of the piston of the cylinder-and-piston assembly is delimited by a stroke length stop when suctioning from the cylinder and is delimited by a readjustment stop when exhausting into the cylinder. The readjustment stop is disposed on the piston or on the cylinder housing and interacts with a fixed stop. The readjustment stop is accessible and adjustable by way of a removable seal. The seal is connected by way of ribs to a piston bearing. The readjustment stop is disposed below this removable seal. The seal has a molding and the piston bearing has a counter molding. Displacement of the seal in relation to the piston bearing moves the seal in the longitudinal direction, and by this movement, the seal is removed in a manner that preferably is not capable of re-assembly.

Abstract: A cylinder-and-piston assembly for a bottle attachment apparatus for handling liquids provides a cylinder attachable to a valve block assembly, a piston, displaceable in a sealed manner in the longitudinal direction within the cylinder, and a cylinder housing connected to the piston and externally encompassing the cylinder. The piston is displaceable in the cylinder and the stroke length of the piston in the cylinder is delimited by a fixed stop, which interacts with a stroke length stop on the cylinder housing. The cylinder housing has a longitudinal slot running in the longitudinal direction and on the external side thereof has a scale assigned to this longitudinal slot. The stroke length stop on the cylinder housing is adjustable in the longitudinal direction and is interlockable in the respective position.

Abstract: An exhaust valve assembly for a bottle attachment apparatus for handling liquids has a valve housing which forms a valve chamber having an inlet and an outlet, an exhaust valve body disposed on the inlet in the valve chamber, and a safety valve body disposed on the outlet in the valve chamber. The exhaust valve body is biased toward an exhaust valve seat, counter to the flow direction of the liquid and the safety valve body is biased toward a safety valve seat in the flow direction of the liquid. The safety valve seat is integrally molded on the valve housing.