Patents by Inventor Markus Landthaler

Markus Landthaler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide targeted to the A20-3? untranslated region
    Patent number: 10731163
    Abstract: An antisense oligonucleotide comprising a sequence targeted to the 3? untranslated region (3? UTR) of the TNFAIP3 (A20) transcript and its use as a medicament, for example in the treatment of cancer or an autoimmune disease.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: August 4, 2020
    Assignee: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
    Inventors: Markus Landthaler, Yasuhiro Murakawa
  • OLIGONUCLEOTIDE TARGETED TO THE A20-THREE PRIME UNTRANSLATED REGION
    Publication number: 20170298359
    Abstract: An antisense oligonucleotide comprising a sequence targeted to the 3? untranslated region (3? UTR) of the TNFAIP3 (A20) transcript and its use as a medicament, for example in the treatment of cancer or an autoimmune disease.
    Type: Application
    Filed: September 2, 2015
    Publication date: October 19, 2017
    Inventors: Markus Landthaler, Yasuhiro Murakawa
  • METHOD FOR IDENTIFICATION OF THE SEQUENCE OF POLY(A)+RNA THAT PHYSICALLY INTERACTS WITH PROTEIN
    Publication number: 20150045237
    Abstract: The invention relates to an in vitro method for identifying the sequence of one or more poly(A)+RNA molecules that physically interacts with protein. The present invention provides a method to define the protein-bound transcriptome under any given cellular condition, such as a disease condition or after treatment with any given substance, drug, or other cellular perturbation. The invention also relates to a method for identification of a drug target and a method for the identification of one or more biomarkers, preferably for identification of a panel of biomarkers, for any given medical condition, comprising the method of the invention.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Inventors: Markus Landthaler, Mathias Munschauer, Alexander Baltz
  • Anti-microRNA oligonucleotide molecules
    Patent number: 8937173
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: January 20, 2015
    Assignee: The Rockefeller University
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA Oligonucleotide Molecules
    Publication number: 20140335605
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 13, 2014
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Methods for identifying RNA segments bound by RNA-binding proteins or ribonucleoprotein complexes
    Patent number: 8841073
    Abstract: The present invention relates to a method for identifying a binding site on an RNA transcript, wherein the binding site binds to one or more binding moieties. The method includes, among other things, introducing a photoreactive nucleoside into living cells wherein the living cells incorporate the photoreactive nucleoside into RNA transcripts during transcription thereby producing modified RNA transcripts; reverse transcribing the RNA of isolated cross-linked segments thereby generating cDNA transcripts with one mutation wherein the photoreactive nucleoside is transcribed to a mismatched deoxynucleoside; amplifying the cDNA transcripts thereby generating amplicons; and analyzing the sequences of the amplicons aligned against the reference sequence so as to identify the binding site, wherein the sequences of each amplicon having a mutation resulting from the introduction of the photoreactive nucleoside is considered to be a valid amplicon comprising at least a portion of a binding site on the RNA transcript.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: September 23, 2014
    Assignee: The Rockefeller University
    Inventors: Markus Landthaler, Manuel Ascano, Jr., Markus Hafner, Thomas Tuschl, Mohsen Khorshid, Lukas Burger, Mihaela Zavolan
  • Anti-microRNA oligonucleotide molecules
    Patent number: 8816060
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: August 26, 2014
    Assignee: Rockefeller University
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA oligonucleotide molecules
    Patent number: 8318926
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: November 27, 2012
    Assignee: Rockefeller University
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA Oligonucleotide Molecules
    Publication number: 20120115220
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 10, 2012
    Applicant: ROCKEFELLER UNIVERSITY
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA oligonucleotide molecules
    Patent number: 8114985
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: February 14, 2012
    Assignee: Rockefeller University
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA Oligonucleotide Molecules
    Publication number: 20110165669
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: March 11, 2011
    Publication date: July 7, 2011
    Applicant: ROCKEFELLER UNIVERSITY
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-microRNA oligonucleotide molecules
    Patent number: 7943756
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: May 17, 2011
    Assignee: Rockefeller University
    Inventors: Thomas H. Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRNA Oligonucleotide Molecules
    Publication number: 20100286385
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: June 4, 2010
    Publication date: November 11, 2010
    Applicant: ROCKEFELLER UNIVERSITY
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-microRNA oligonucleotide molecules
    Patent number: 7772389
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: August 10, 2010
    Assignee: Rockefeller University
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
  • Anti-MicroRna Oligonucleotide Molecules
    Publication number: 20070287179
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: February 11, 2005
    Publication date: December 13, 2007
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Pfeffer Sebastion
  • Anti-microRNA oligonucleotide molecules
    Publication number: 20050182005
    Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
    Type: Application
    Filed: May 13, 2004
    Publication date: August 18, 2005
    Inventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer