Abstract: This invention relates to macrocyclic cavity containing compounds and uses thereof in inhibiting a microbial signalling molecule or in reducing the amount of a microbial signalling molecule in a subject. The invention also relates to methods for inhibiting a microbial signalling molecule or for reducing the amount of a microbial signalling molecule in a subject by contacting a macrocyclic cavity-containing compound with said subject.

Abstract: The present disclosure provides a method comprising administering a labeled collagen hybridizing peptide (LCHP) to the subject, and imaging the LCHP, thereby detecting the presence or progression of fibrosis in the subject.

Abstract: This invention relates to inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient. The present invention relates also to an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient for use in a method of treating an infection in a subject. In addition, the present invention relates to a method of treating an infection in a subject by administering an inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient to the subject. The inhalable formulation comprising a macrocyclic, cavity-containing compound as a biologically active ingredient is suitable for the treatment of pulmonary or systemic infections caused by Gram-positive or Gram-negative bacteria.

Abstract: This invention relates to use of a macrocyclic cavity-containing compound sensitizing a microbe towards an antimicrobial agent. The invention also relates to use of a macrocyclic cavity-containing compound in reducing the amount of an antimicrobial agent needed to prevent or inhibit the growth of a microbe in a subject. Further, the invention relates to use of a macrocyclic cavity-containing compound in reducing the build-up of resistance of a microbe towards an anti-microbial agent. The invention also relates to a macrocyclic cavity-containing compound and an antimicrobial agent for use in inhibiting/treating/preventing a microbial infection in a subject having a microbial infection or being at risk of a microbial infection.

Abstract: The present invention is directed to a method for producing a condensed phase of a silk fusion protein, the method comprising the steps of preparing a solution of a silk fusion protein in an aqueous medium and concentrating the silk fusion protein in the aqueous medium, wherein the fusion protein is isolated from a recombinant production host and comprises a silk-like protein sequence and two separate non-silk terminal module sequences, such as cellulose binding modules, SpyCatcher domains, tenth type III module of Fibronectin, gamma-crystallin D, flanking the silk-like protein sequence; wherein the method is performed so that the silk fusion protein is not precipitated and subsequently dissolved to the aqueous medium. The present invention is also directed to using such fusion proteins as adhesives.

Abstract: This invention relates to macrocyclic cavity containing compounds and uses thereof in inhibiting a microbial signalling molecule or in reducing the amount of a microbial signalling molecule in a subject. The invention also relates to methods for inhibiting a microbial signalling molecule or for reducing the amount of a microbial signalling molecule in a subject by contacting a macrocyclic cavity-containing compound with said subject.

Abstract: The present invention is directed to a method for producing a condensed phase of a silk fusion protein, the method comprising the steps of preparing a solution of a silk fusion protein in an aqueous medium and concentrating said silk fusion protein in said aqueous medium, wherein said fusion protein is isolated from a recombinant production host and comprises a silk-like protein sequence and two separate non-silk terminal module sequences, such as cellulose binding modules, SpyCatcher domains, tenth type III module of Fibronectin, gamma-crystallin D, flanking said silk-like protein sequence; wherein the method is performed so that said silk fusion protein is not precipitated and subsequently dissolved to said aqueous medium. The present invention is also directed to using such fusion proteins as adhesives.

Abstract: In a method for regulating a fuel cell stack (1), a current-voltage characteristic of the fuel cell stack is detected and evaluated to determine an operating point of the fuel cell stack, wherein a current-voltage characteristic of the fuel cell stack (1) is detected at time intervals in operation whose gradient has a minimum, a characteristic value (Rmin) for the minimum of the gradient is respectively determined from the detected current-voltage characteristic and a desired value for the operating point is determined by addition of a predefined offset value (Roffset) to the characteristic value, and wherein the fuel cell stack (1) is regulated by the desired value determined in this manner.

Abstract: The present invention relates to a purification and concentration method for proteins and antibodies. Particularly the present invention relates to a continuous surfactant based phase separation method for recovering hydrophobin fusion proteins, and for recovering target molecules, such as antibodies, directly from a liquid by using phase separation and hydrophobin-Protein A fusion technologies.

Abstract: This document describes graphene-containing platelets and methods of exfoliating graphene from a surface. The method comprises facilitating exfoliation by treatment with proteins. In an embodiment, the proteins adhere to the surface of graphene and then the produced platelets may contain a graphene layer and a protein layer on the surface of the graphene layer. Electronic devices containing such platelets are also described.

Abstract: The present invention relates to a purification and concentration method for proteins and antibodies. Particularly the present invention relates to a continuous surfactant based phase separation method for recovering hydrophobin fusion proteins, and for recovering target molecules, such as antibodies, directly from a liquid by using phase separation and hydrophobin-Protein A fusion technologies.

Abstract: In a method for regulating a fuel cell stack (1), a current-voltage characteristic of the fuel cell stack is detected and evaluated to determine an operating point of the fuel cell stack, wherein a current-voltage characteristic of the fuel cell stack (1) is detected at time intervals in operation whose gradient has a minimum, a characteristic value (Rmin) for the minimum of the gradient is respectively determined from the detected current-voltage characteristic and a desired value for the operating point is determined by addition of a predefined offset value (Roffset) to the characteristic value, and wherein the fuel cell stack (1) is regulated by the desired value determined in this manner.

Abstract: In the field of drug or nutrient administration novel particles and formulations thereof are provided. Said particles each have a core comprising active agent and at least partial coating comprising proteins, selected from hydrophobins. Preferable hydrophobins belong to class I or class II. Said particles exhibit enhanced characteristics, for example dispersibility or solubility. Here is also disclosed two methods for producing said particles in nanoscale, of which one utilizes precipitating and another wet milling.

Abstract: This document describes a method of producing an electronic device comprising biological and electrical materials and an interface between the biological and electrical materials. The method utilizes self-assembly of proteins (11) at a desired location when producing the electronic device. The document also describes electronic devices that include a protein layer as a structural part thereof. The protein layers of the electronic devices containing hydrophobin proteins are also presented. According to some embodiment, the electronic devices also include a layer of graphene (12) in contact with the proteins (11).

Abstract: This document describes graphene-containing platelets and methods of exfoliating graphene from a surface. The method comprises facilitating exfoliation by treatment with proteins. In an embodiment, the proteins adhere to the surface of graphene and then the produced platelets may contain a graphene layer and a protein layer on the surface of the graphene layer. Electronic devices containing such platelets are also described.

Abstract: The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.

Abstract: This, invention relates to a method for cleaving proteins or peptides at a specific site. According to the invention an amino acid sequence is constructed at a predetermined cleavage site and the protein or peptide is allowed to react with free metal ions in a buffer. The buffer further comprises a reducing or oxidizing agent for enhancing the cleavage. The amino acids in the amino acid sequence are selected from the group comprising histidine, lysine, tryptophan, arginine, tyrosine, phenylalanine, and cysteine.

Abstract: The present invention relates to isolation and purification of proteins in aqueous two-phase systems (ATPS). Specifically the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.

Abstract: The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.