Patents by Inventor Markus Mandler

Markus Mandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240148782
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 9, 2024
    Inventors: Markus Mandler, Achim Schneeberger, Wolfgang Zauner, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Patent number: 11857568
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: January 2, 2024
    Assignee: Advantage Therapeutics, Inc.
    Inventors: Markus Mandler, Achim Schneeberger, Wolfgang Zauner, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Publication number: 20230201320
    Abstract: A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPWPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVWPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102),
    Type: Application
    Filed: November 21, 2022
    Publication date: June 29, 2023
    Applicant: AC Immune SA
    Inventors: Markus MANDLER, Harald WENINGER, Radmila SANTIC, Edith KOPINITS
  • Patent number: 11534484
    Abstract: A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPVVPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVWPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102), (C)YDRPVQPDR (SEQ ID NO: 103), (C)DMPVDADN (SEQ ID NO: 105), DQPVLPD(C) (SE
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: December 27, 2022
    Assignee: AC Immune SA
    Inventors: Markus Mandler, Harald Weninger, Radmila Santic, Edith Kopinits
  • Publication number: 20220062412
    Abstract: Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 3, 2022
    Inventors: Markus Mandler, Achim Schneeberger, Frank Mattner, Walter Schmidt
  • Publication number: 20220000908
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 6, 2022
    Inventors: Markus Mandler, Achim Schneeberger, Wolfgang Zauner, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Patent number: 11147873
    Abstract: Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: October 19, 2021
    Assignee: Advantage Therapeutics, Inc.
    Inventors: Markus Mandler, Achim Schneeberger, Frank Mattner, Walter Schmidt
  • Patent number: 11065273
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: July 20, 2021
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Achim Schneeberger, Wolfgang Zauner, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Publication number: 20200369738
    Abstract: The invention discloses Fibroblast growth factor 2 (FGF2) and Fibroblast growth factor 7 (FGF7) messenger-RNA (mRNA), wherein the mRNA has a 5? CAP region, a 5? untranslated region (5?-UTR), a coding region, a 3? untranslated region (3?-UTR) and a poly-adenosine tail (poly-A tail), for use in the treatment of local skin hypotrophy conditions and kits for administrating this mRNA to a human patient in need thereof.
    Type: Application
    Filed: July 31, 2018
    Publication date: November 26, 2020
    Inventors: Markus MANDLER, Frank MATTNER, Walter SCHMIDT, Achim SCHNEEBERGER
  • Publication number: 20200338192
    Abstract: Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.
    Type: Application
    Filed: March 17, 2020
    Publication date: October 29, 2020
    Applicant: AFFIRIS AG
    Inventors: Markus MANDLER, Achim SCHNEEBERGER, Frank MATTNER, Walter SCHMIDT
  • Publication number: 20200254076
    Abstract: A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPVVPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVWPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102), (C)YDRPVQPDR (SEQ ID NO: 103), (C)DMPVDADN (SEQ ID NO: 105), DQPVLPD(C) (SE
    Type: Application
    Filed: December 11, 2019
    Publication date: August 13, 2020
    Applicant: AFFIRIS AG
    Inventors: Markus MANDLER, Harald WENINGER, Radmila SANTIC, Edith KOPINITS
  • Patent number: 10646565
    Abstract: Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 12, 2020
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Achim Schneeberger, Frank Mattner, Walter Schmidt
  • Publication number: 20200038487
    Abstract: The invention discloses Interferon alpha (IFN-?) messenger-RNA (mRNA), wherein the mRNA has a 5? CAP region, a 5? untranslated region (5?-UTR), a coding region, a 3? untranslated region (3?-UTR) and a poly-adenosine tail (poly-A tail), for use in the prevention and treatment of non-melanoma skin cancer (NMSC) and kits for administrating this IFN-? mRNA to a human patient.
    Type: Application
    Filed: March 29, 2018
    Publication date: February 6, 2020
    Inventors: Markus MANDLER, Achim SCHNEEBERGER, Walter SCHMIDT, Frank MATTNER
  • Patent number: 10517935
    Abstract: A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPVVPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVLPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102), (C)YDRPVQPDR (SEQ ID NO: 103), (C)DMPVDADN (SEQ ID NO: 105), DQPVLPD(C) (SE
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: December 31, 2019
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Harald Weninger, Radmila Santic, Edith Kopinits
  • Patent number: 10478454
    Abstract: The invention discloses aluminium oxyhydroxide for use in the treatment and prevention of AD.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: November 19, 2019
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Achim Schneeberger, Arne Von Bonin, Frank Mattner, Walter Schmidt
  • Patent number: 9964547
    Abstract: Disclosed is a method for detecting aSyn-specific antibodies in a biological sample, comprising the following steps: —contacting the sample with aSyn-comprising-aggregates and allowing the aSyn-specific antibodies to bind to the aSyn-comprising-aggregates, and —detecting the aSyn-specific antibodies bound to the aSyn-comprising-aggregates by a single particle detection technique, preferably by fluorescence activated cell sorting (FACS).
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: May 8, 2018
    Assignee: AFFIRIS AG
    Inventors: Guenther Staffler, Markus Mandler, Andreas Mairhofer, Arne Von Bonin
  • Patent number: 9724399
    Abstract: The present invention relates to the use of at least one compound comprising the amino acid sequence (Formula?1) (SEQ?ID?NO:?57) (X1)nX2X3PVX4X5X6(X7)m, wherein X1 is any amino acid residue, X2 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E), X3 is any amino acid residue, X4 is any amino acid residue, X5 is an amino acid residue selected from the group consisting of proline (P) and alanine (A), X6 is an amino acid residue selected from the group consisting of aspartic acid (D) and glutamic acid (E), X7 is any amino acid residue, n and m, independently, are 0 or an integer of more than 0, and wherein the amino acid sequence according to Formula I is not identical with, or does not comprise the 8-mer polypeptide fragment of alpha-synuclein having the amino acid sequence DMPVDPDN (SEQ ID NO: 1), said compound having a binding capacity to an antibody which is specific for an epitope of alpha-synuclein comprising the amino acid sequen
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: August 8, 2017
    Assignee: AFFIRIS AG
    Inventors: Markus Mandler, Harald Weninger, Radmila Santic, Edith Kopinits
  • Publication number: 20170158744
    Abstract: A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPVVPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVLPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102), (C)YDRPVQPDR (SEQ ID NO: 103), (C)DMPVDADN (SEQ ID NO: 105), DQPVLPD(C) (SE
    Type: Application
    Filed: December 12, 2016
    Publication date: June 8, 2017
    Applicant: AFFIRIS AG
    Inventors: Markus MANDLER, Harald Weninger, Radmila Santic, Edith Kopinits
  • Publication number: 20170056495
    Abstract: Disclosed is a method for the treatment of AD, wherein an immune stimulating pharmaceutical composition comprising an aluminium salt is administered to a patient having AD or having a risk to develop AD in an effective amount.
    Type: Application
    Filed: April 29, 2015
    Publication date: March 2, 2017
    Applicant: AFFIRIS AG
    Inventors: Markus MANDLER, Achim SCHNEEBERGER, Frank MATTNER, Walter SCHMIDT
  • Publication number: 20170049810
    Abstract: The invention discloses an aluminium salt for use in the treatment and prevention of dementias associated with ?-amyloid deposition, preferably AD.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 23, 2017
    Applicant: AFFIRIS AG
    Inventors: Markus MANDLER, Achim SCHNEEBERGER, Wolfgang ZAUNER, Ame VON BONIN, Frank MATTNER, Walter SCHMIDT