Abstract: The present invention relates to a method of treating a tumor disease, comprising one or more administrations of a T cell product, a T cell product for use in a method of treating a tumor disease, as well as a kit for use in a method of treating a tumor disease.

Abstract: A method for operating a vehicle drive train (1) comprising a prime mover (2), transmission (3), and comprising a driven end (4) may include limiting, during a demand for engaging a form-locking shift element (A, F) of the transmission (3) when a rotational speed of the driven end (4) is close to zero, a rate of change of a transmission input torque present at the form-locking shift element (A, F) to a value. Below the value, forces present at the form-locking shift element (A, F) during an engagement process are less than a load limit. Above the value, irreversible damage to the form-locking shift element (A, F) occurs.

Abstract: A method for operating a vehicle drive train (1) comprising a prime mover (2), transmission (3), and comprising a driven end (4) may include limiting, during a demand for engaging a form-locking shift element (A, F) of the transmission (3) when a rotational speed of the driven end (4) is close to zero, a rate of change of a transmission input torque present at the form-locking shift element (A, F) to a value. Below the value, forces present at the form-locking shift element (A, F) during an engagement process are less than a load limit. Above the value, irreversible damage to the form-locking shift element (A, F) occurs.

Abstract: A method for operating an automatic transmission includes determining at least one of an elapsed time from adjusting a first one of at least one positive-locking shift element towards a closed configuration or a differential speed rotation of the first one of the at least one positive-locking shift element and shifting the automatic transmission to a substitute gear if the elapsed time from adjusting the first one of the at least one positive-locking shift element towards the closed configuration reaches or exceeds a time limit and/or the differential speed rotation of the first one of the at least one positive-locking shift element reaches or exceeds a rotational speed limit. A related transmission control device for an automatic transmission is also provided.

Abstract: A method for operating an automatic transmission is provided. The method includes initiating a synchronization of a positive shifting element of the automatic transmission. The method also includes closing a first non-positive shifting element of the automatic transmission and positioning a second non-positive shifting element of the automatic transmission at an engaged configuration of the second non-positive shifting element during the synchronization of the first positive shifting element in order to synchronize the first positive shifting element.

Abstract: A method is provided for executing a gearshift in an automatic transmission with several shifting elements. Upon the execution of the gearshift, a first frictional-locking shifting element is opened and a second positive-locking shifting element is closed. If, upon the execution of the gearshift, an input torque of the automatic transmission is less than a threshold value, after at least partially opening the frictional-locking shifting element and after releasing the positive-locking shifting element, there is a monitoring of whether the positive-locking shifting element is transferred into its end position. If it is then determined that the positive-locking shifting element is not in its end position, a torque transferred by the partially open frictional-locking shifting element initially increases.

Abstract: A method for operating an automatic transmission is provided. The method includes synchronizing a positive shifting element of the automatic transmission, braking the automatic transmission with a first non-positive shifting element of the automatic transmission, establishing a position of the positive shifting element, and increasing a pressure of fluid supplied to a second non-positive shifting element of the automatic transmission if the position of the positive shifting element is an intermediate position.

Abstract: A method for operating an automatic transmission is provided. The method includes synchronizing a positive shifting element of the automatic transmission, braking the automatic transmission with a first non-positive shifting element of the automatic transmission, establishing a position of the positive shifting element, and increasing a pressure of fluid supplied to a second non-positive shifting element of the automatic transmission if the position of the positive shifting element is an intermediate position.

Abstract: A method for operating an automatic transmission includes determining at least one of an elapsed time from adjusting a first one of at least one positive-locking shift element towards a closed configuration or a differential speed rotation of the first one of the at least one positive-locking shift element and shifting the automatic transmission to a substitute gear if the elapsed time from adjusting the first one of the at least one positive-locking shift element towards the closed configuration reaches or exceeds a time limit and/or the differential speed rotation of the first one of the at least one positive-locking shift element reaches or exceeds a rotational speed limit. A related transmission control device for an automatic transmission is also provided.

Abstract: A method for operating an automatic transmission is provided. The method includes initiating a synchronization of a positive shifting element of the automatic transmission. The method also includes closing a first non-positive shifting element of the automatic transmission and positioning a second non-positive shifting element of the automatic transmission at an engaged configuration of the second non-positive shifting element during the synchronization of the first positive shifting element in order to synchronize the first positive shifting element.

Abstract: Method for executing a gearshift in an automatic transmission (1) with several shifting elements, whereas, upon the execution of the gearshift, a first frictional-locking shifting element (B, C, D, E) is open or switched off and a second positive-locking shifting element (A, F) is closed or switched on, whereas, if, upon the execution of the gearshift, an input torque of the automatic transmission is then smaller than a threshold value, in particular upon the execution of a coast downshift, after at least the partial opening of the frictional-locking shifting element (B, C, D, E) and after the release of the positive-locking shifting element (A, F), there is a monitoring of whether the positive-locking shifting element (A, F) is transferred into its end position, whereas, if it is then determined that the positive-locking shifting element (A, F) has not been transferred into its end position, a torque transferred by the previously at least partially open frictional-locking shifting element (B, C, D, E) initia

Abstract: Method for executing gearshifts interlaced into each other in an automatic transmission with several shifting elements, whereas, upon the execution of gearshifts interlaced into each other, first shifting elements are open or switched off, and second shifting elements are closed or switched on, namely in such a manner that, as a second shifting element, at least one positive-locking shifting element is closed, whereby, with the activation of a positive-locking shifting element to be closed, there is a monitoring of whether, within a time interval after the activation of the particular positive-locking shifting element to be closed, the transmission ratio of the automatic transmission is within the tolerance band and is thus constant, and/or whether an end position sensor of the particular positive-locking shifting element to be closed detects a completely engaged position of the positive-locking shifting element to be closed, whereby, if at least one of these conditions is met, a proper closing of the particu

Abstract: A transmission comprising a transmission (7) and a reduction stage. Sun of set (P1) is connected to the input (1), which can be releasably connected, via clutch (A), to shaft (6) connected to sun of set (P2) and sun of set (P3), and, via clutch (B), is connectable to shaft (5) connected to carrier of set (P2) and ring of set (P3). Shaft (5) is coupled to housing (G) via brake (F). Carrier of set (P1) is connected to shaft (4) connected with ring of set (P2) and is couplable, via brake (E), to housing (G). Ring of set (P1) is connected to shaft (3) which is couplable, via brake (D), to housing (G). Output (2) is connected to carrier of set (P3). Carrier of set (P4) is connected to output (2), ring of set (P4) is couplable, via brake (H), to housing (G), and sun of set (P4) is connected to the shaft (6).

Abstract: A method of shifting at least one of a speed increasing stage (H) and/or a speed reductions stage (L) in a claw shifted transfer gear box (VG) in a drive train of a vehicle having a drive engine and a load shiftable shift transmission (SG). The transfer gearbox (VG) is shifted into the neutral position (N) and, after the synchronization, is shifted into the speed increasing stage (H) or the speed reductions stage (L). During synchronization, the shift transmission (SG) is decelerated or accelerated, by activating at least an additional shift element, so that the output rotational speed (n_SG) of the shift transmission (SG) is matched to the output rotational speed (n_VG) of the transfer gearbox (VG), multiplied by the target gear ratio in the transfer gear box (VG).

Abstract: A transmission having basic and reversing transmissions. The basic transmission has planetary gearsets, shafts and shift elements. A sun of gearset (P1) couples the drive shaft, which can couple shaft (6) and the suns of gearsets (P2, P3), and shaft (5) and the carrier and ring of gearsets (P2, P3) respectively. Carrier of gearset (P1) couples shaft (4), which couples the ring of gearset (P2). The ring of gearset (P1) couples shaft (3). Shafts (3, 4, 5) can couple the housing. The output shaft couples the carrier of gearset (P3). The reversing transmission has a minus planetary gearset with a sun which couples and is driven by the basic transmission output, and a carrier that can couple the housing via a locking element, and a ring that couples the reversing transmission output which can couple, via another locking element, the basic transmission output.

Abstract: A multistage transmission in planetary design is proposed, comprising a basic transmission (8) and a group transmission (9) downstream of the basic transmission (8), wherein the basic transmission (8) comprises three planetary gear set (P1, P2, P3), at least six rotatable shafts (1, 2, 3, 4, 5, 6) and at least five shift elements (A, B, D, E, F), the selected engagement of which results in different transmission ratios between the input drive and the output drive, wherein the group transmission (9) has a minus planetary gear set (P4), the sun gear of which is connected to the output shaft (2) of the basic transmission (8), the ring gear of which can be coupled to the housing (G) via a first shift element (K1), and the carrier of which is connected to the output shaft (7) of the multistage transmission, which can be releasably connected to the ring gear via a second shift element (K2), and wherein the basic transmission (8) and the group transmission (9) are disposed in a common housing (G).

Abstract: A transmission having basic and reversing transmissions. The basic transmission has planetary gearsets, shafts and shift elements. A sun of gearset (P1) couples the drive shaft, which can couple shaft (6) and the suns of gearsets (P2, P3), and shaft (5) and the carrier and ring of gearsets (P2, P3) respectively. Carrier of gearset (P1) couples shaft (4), which couples the ring of gearset (P2). The ring of gearset (P1) couples shaft (3). Shafts (3, 4, 5) can couple the housing. The output shaft couples the carrier of gearset (P3). The reversing transmission has a minus planetary gearset with a sun which couples and is driven by the basic transmission output, and a carrier that can couple the housing via a locking element, and a ring that couples the reversing transmission output which can couple, via another locking element, the basic transmission output.

Abstract: A transmission comprising a transmission (7) and a reduction stage. Sun of set (P1) is connected to the input (1), which can be releasably connected, via clutch (A), to shaft (6) connected to sun of set (P2) and sun of set (P3), and, via clutch (B), is connectable to shaft (5) connected to carrier of set (P2) and ring of set (P3). Shaft (5) is coupled to housing (G) via brake (F). Carrier of set (P1) is connected to shaft (4) connected with ring of set (P2) and is couplable, via brake (E), to housing (G). Ring of set (P1) is connected to shaft (3) which is couplable, via brake (D), to housing (G). Output (2) is connected to carrier of set (P3). Carrier of set (P4) is connected to output (2), ring of set (P4) is couplable, via brake (H), to housing (G), and sun of set (P4) is connected to the shaft (6).

Abstract: A multistage transmission of a planetary design which comprises a basic transmission and a group transmission arranged downstream of the basic transmission. The basic transmission comprises three planetary gearsets, at least six rotatable shafts and at least five shift elements, and selected engagement thereof which results in different transmission ratios between an input and an output drive. The group transmission has a minus planetary gearset. The sun gear of the minus planetary gearset is connected to the output shaft of the basic transmission. The ring gear of the minus planetary gearset can be coupled to the housing, via a first shift element. The carrier of the minus planetary gearset is connected to the output shaft of the multi-stage transmission and is connectable to the ring gear, via a second shift element. The basic and the group transmissions are arranged together within the housing.

Abstract: An internal combustion engine has a cylinder (2) wherein a combustion chamber (3) is formed which is delimited by a piston (5) journalled to move back and forth. At least one transfer channel (14) is provided which connects the crankcase (4) of the engine to the combustion chamber (3) in at least one position of the piston (5). The engine has a supply channel (13) which opens with a supply channel inlet (11) at the cylinder bore (34). The supply channel (13) is connected to the transfer channel (14) via at least one piston pocket (22, 42) in at least one position of the piston (5). In order to achieve low exhaust-gas values of the engine, the piston pocket (22, 42) has a distance (a) to a lower edge (27) of the transfer window (15) which is less than the distance (b) to a lower edge (26) of the inlet (11) of the supply channel at bottom dead center of the piston (5).