Abstract: The present disclosure relates to a method of a method of treating a cholangiopathy (e.g., Primary Sclerosing Cholangitis or Primary Biliary Cholangitis) in a human subject in need thereof, comprising administering a therapeutically effective amount of an anti-Claudin-1 antibody to the human subject.

Abstract: A slider tool has a slider bed and a slider movably mounted thereon by means of gliding plates (G1, G2) on a dovetail guide, wherein an unsymmetrical concept of the dovetail connection is provided.

Abstract: The present disclosure relates to a method of treating a cholangiocarcinoma in a human subject in need thereof, comprising administering a therapeutically effective amount of an anti-Claudin-1 antibody to the human subject.

Abstract: A slider arrangement (1) has a wedge drive tool with a slider upper portion (10) and a slider lower portion (20) which, due to a relative movement with respect to the slider upper portion (10), can be displaced along guides (30) from an initial position into a working position and vice versa. At least one return device (40) is provided in order to bring about the initial position of the slider upper portion (10) and slider lower portion (20), wherein the return device (40) has a screw plug (50) at the end in order to attach the return device (40) in a recess (11) of the slider arrangement (1). The screw plug (50) can have one or at least two rotation prevention part(s) (51) designed to prevent a rotation of the screw plug (50) beyond a maximum acceptable rotation angle ?.

Abstract: An on-load tap changer module for an on-load tap changer, including a carrier, a diverter switch with a vacuum interrupter and a bridge switch, a selector, a change-over selector, and a drive module, wherein the diverter switch, the selector, and the change-over selector are arranged on the carrier and are activated centrally by the drive module.

Abstract: The present disclosure relates to a method of promoting T cell mediated anti-tumor activity in a subject having a fibrotic tumor, comprising administering an anti-Claudin-1 antibody to the subject.

Abstract: Systems, methods, and apparatuses relating to a pallet container for storing and transporting fluid or flowable filling materials are disclosed. The pallet container can comprise a container including an upper base that defines a plane; a frame surrounding at least some of the container and including horizontal and vertical rods joined to form at least one pair of opposing walls; and a cross-member that is detachably attached to the pair of opposing walls, defines a length along a line of curvature that is greater than a distance between the pair of opposing walls, and is oriented on a second plane that is parallel to the first plane.

Abstract: The present invention describes a pallet container (10) for storing and transporting fluid or flowable filling materials, having a thin-walled, rigid plastics inner container (12) made from thermoplastic plastics material, having a tubular grid frame (14) which tightly surrounds the plastics inner container (12) as a supporting covering and which comprises horizontal and vertical tubular rods (18, 20) which are welded to each other, and having a base pallet (16) on which the plastics inner container (12) is positioned and to which the tubular grid frame (14) is securely connected, wherein at least two rod-shaped transverse cross-members (22) are provided above the plastics inner container (12) and are fixed with the two ends thereof to two mutually opposite side walls in the upper region of the tubular grid frame (14).

Abstract: The present invention describes a pallet container (10) for storing and transporting fluid or flowable filling materials, having a thin-walled, rigid plastics inner container (12) made from thermoplastic plastics material, having a tubular grid frame (14) which tightly surrounds the plastics inner container (12) as a supporting covering and which comprises horizontal and vertical tubular rods (18, 20) which are welded to each other, and having a base pallet (16) on which the plastics inner container (12) is positioned and to which the tubular grid frame (14) is securely connected, wherein at least two rod-shaped transverse cross-members (22) are provided above the plastics inner container (12) and are fixed with the two ends thereof via a screw connection to two mutually opposite side walls in the upper region of the tubular grid frame (14).

Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.

Abstract: The present invention describes a pallet container (10) for storing and transporting fluid or flowable filling materials, having a thin-walled, rigid plastics inner container (12) made from thermoplastic plastics material, having a tubular grid frame (14) which tightly surrounds the plastics inner container (12) as a supporting covering and which comprises horizontal and vertical tubular rods (18, 20) which are welded to each other, and having a base pallet (16) on which the plastics inner container (12) is positioned and to which the tubular grid frame (14) is securely connected, wherein at least two rod-shaped transverse cross-members (22) are provided above the plastics inner container (12) and are fixed with the two ends thereof via a screw connection to two mutually opposite side walls in the upper region of the tubular grid frame (14).

Abstract: The present invention describes a pallet container (10) for storing and transporting fluid or flowable filling materials, having a thin-walled, rigid plastics inner container (12) made from thermoplastic plastics material, having a tubular grid frame (14) which tightly surrounds the plastics inner container (12) as a supporting covering and which comprises horizontal and vertical tubular rods (18, 20) which are welded to each other, and having a base pallet (16) on which the plastics inner container (12) is positioned and to which the tubular grid frame (14) is securely connected, wherein at least two rod-shaped transverse cross-members (22) are provided above the plastics inner container (12) and are fixed with the two ends thereof to two mutually opposite side walls in the upper region of the tubular grid frame (14).

Abstract: In accordance with an embodiment, a gas-sensitive device includes a substrate structure, and a gas sensitive capacitor. The gas sensitive capacitor a first capacitor electrode in form of a gas-sensitive layer on a first main surface region of an insulation layer, and a second capacitor electrode in form of a buried conductive region below the insulation layer, so that the insulation layer is arranged between the first and second capacitor electrode. The gas-sensitive layer comprises a sheet impedance which changes in response to the adsorption or desorption of gas molecules.

Abstract: A sensor chip includes a substrate and one or more chemo-resistive gas sensing elements attached to the substrate. Each gas sensing element provides a signal depending on one or more gases to be sensed. A catalytic gas filter arrangement includes one or more filter sections, each filter section including a cavity covered with at least one membrane. The at least one membrane is supported by a support structure and includes gas permeable pores. A surface defining the pores includes a catalytic material for degrading one or more of the gases. The gas filter arrangement is arranged so at least one of the chemo-resistive gas sensing elements is exposed to a filtered mixture of the gases in the cavity of one of the filter sections. The filtered mixture of gases is obtained by filtering the ambient mixture of the one or more gases with the one of the filter sections.

Abstract: A lower pacing rate limit is utilized by pacing devices to initiate pacing in response to a patient's intrinsic rate being less than the lower pacing rate limit. Illustrative systems, devices, and methods may obtain rate modification information related to a patient such as physical characteristics, diagnostic parameters, pathologies, device characteristics of a pacing device implanted in the patient, and patient-reported information. The rate modification information may be used to determine lower pacing rate limit based thereon.

Abstract: An on-load tap changer module for an on-load tap changer, including a carrier, a diverter switch with a vacuum interrupter and a bridge switch, a selector, a change-over selector, and a drive module, wherein the diverter switch, the selector, and the change-over selector are arranged on the carrier and are activated centrally by the drive module.

Abstract: The invention relates to a slider arrangement (1) designed in particular as a wedge drive tool with a slider upper portion (10) and a slider lower portion (20) which, due to a relative movement with respect to the slider upper portion (10), can be displaced along guides (30) from an initial position into a working position and vice versa, wherein at least one return device (40) is provided in order to bring about the initial position of the slider upper portion (10) and slider lower portion (20), wherein the return device (40) comprises a screw plug (50) at the end in order to attach the return device (40) in a recess (11) of the slider arrangement (1), characterized in that the screw plug (50) comprises at least two rotation prevention means (51) which are designed to prevent a rotation of the screw plug (50) beyond a maximum acceptable rotation angle ?.

Abstract: A method for manufacturing an electronic component includes providing a substrate and a functional layer supported by the substrate; forming a structured protection layer on a side of the substrate to which the functional layer is attached, wherein the structured protection layer has a recess so that a portion of the functional layer is exposed; applying a dispersion comprising a solvent and electrically conductive components to the exposed portion of the functional layer so that the recess is at least partially filled with the dispersion; drying the dispersion in order to create an electrically conductive layer; and removing the structured protection layer.

Abstract: A wedge drive (1) has a slide upper part (4), a slide lower part (2), and a slide (3) arranged between the slide upper part (4) and the slide lower part (2). The slide (3) is movable between a closed and an open position in a working position. The slide (3) has a variable-position device (10), a first stop (30) and second stop (40), to obtain either the working position or an installation position. In the working position, the device (10) is positioned so that it is used as the limiter for the first stop (30) when the wedge drive (1) is actuated or is in its intended fully open position. In the installation position, the device (10) is positioned so that the second stop (40) supports itself on the device (10).

Abstract: A wedge drive is provided having a first and a second wedge drive part and an adjustable guide apparatus, formed at least in part by the first and second wedge drive parts, which are movable, by means of a stroke directed in a stroke direction (Z), toward each other in a sliding direction (X, X?, X?) determined by the guide apparatus and at an angle to the stroke direction (Z), guided by the guide apparatus, wherein a guide part of the guide apparatus is movable along a forced guidance surface by adjusting the position of an adjustment surface and a guide play can be set as a result, wherein a normal vector (N) of the forced guidance surface is at an angle to a plane of movement spanned by the stroke direction (Z) and the sliding direction (X, X?, X?).