Patents by Inventor Markus Moosmeier

Markus Moosmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEIMMUNIZED ANTIBODIES SPECIFIC FOR CD3
    Publication number: 20250206819
    Abstract: The present invention provides affinity optimized and deimmunized human antibodies that specifically bind to CD3. The present disclosure also provides bispecific antibodies comprising the optimized human antibodies e.g. for activating of T cells. The invention further relates to methods of generating the human antibodies and methods of using them in the treatment of diseases.
    Type: Application
    Filed: March 21, 2023
    Publication date: June 26, 2025
    Inventors: Markus MOOSMEIER, Andreas BÜLTMANN, Steffen RUNZ
  • COMBINATIONS OF ANTIGEN BINDING MOLECULES
    Publication number: 20250101103
    Abstract: The present disclosure provides combinations or sets of two antigen binding molecule, in particular asymmetric combinations of such antigen binding molecules. Each of the two antigen binding molecules is composed of a targeting moiety with specificity for a tumor associated antigen fused to either the VL or VH domain of an antibody Fv domain specific for CD3. Once the two antigen binding molecules bind to their target antigen on the surface of a cell, the complementary VL and VH domain are capable to associate with each other thereby reconstituting the functional CD3 specific Fv domain and non-covalently dimerizing the two antigen binding molecules. The thus on-cell formed trispecific heterodimeric antibody molecule is capable of engaging and stimulating cytotoxic T-cells for tumor cell destruction.
    Type: Application
    Filed: July 27, 2022
    Publication date: March 27, 2025
    Inventors: Markus MOOSMEIER, Nicole HAUBST, Yvonne STARK
  • NOVEL HUMAN ANTIBODIES BINDING TO HUMAN CD3 EPSILON
    Publication number: 20230357398
    Abstract: The present disclosure provides novel fully human antibodies and antibody fragments specific for human CD3 epsilon.
    Type: Application
    Filed: September 22, 2021
    Publication date: November 9, 2023
    Inventors: Andreas BÜLTMANN, Steffen RUNZ, Tschimegma BATAA, Markus MOOSMEIER, Nicole HAUBST, Jürgen KLATTIG, Yvonne STARK
  • Polypeptide library
    Patent number: 11085038
    Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: August 10, 2021
    Assignee: MORPHOSYS AG
    Inventors: Roger Müller, Andreas Bültmann, Josef Prassler, Markus Moosmeier
  • POLYPEPTIDE LIBRARY
    Publication number: 20200231963
    Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
    Type: Application
    Filed: April 8, 2020
    Publication date: July 23, 2020
    Inventors: Roger Müller, Andreas Bültmann, Josef Prassler, Markus Moosmeier
  • Polypeptide library
    Patent number: 10655125
    Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: May 19, 2020
    Assignee: MOR0059US.NP
    Inventors: Roger Müller, Andreas Bültmann, Josef Prassler, Markus Moosmeier
  • POLYPEPTIDE LIBRARY
    Publication number: 20190270981
    Abstract: The invention relates to novel polypeptide libraries that are conformationally constrained in an anti-parallel, helix-turn-helix arrangement. The invention further relates to methods of generating and screening such libraries for biological, pharmaceutical and other uses.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 5, 2019
    Inventors: Roger Müller, Andreas Bültmann, Josef Prassler, Markus Moosmeier