Abstract: The present invention relates to an oral thin film comprising at least one matrix polymer and at least one active pharmaceutical ingredient, wherein the at least one active pharmaceutical ingredient is an acid or a base, characterised in that the at least one active pharmaceutical ingredient is present in the form of a mixture which comprises the at least one active pharmaceutical ingredient both in the form of the free acid or base and in the form of a pharmaceutically acceptable salt, a method for producing said oral thin film, and the use of such an oral thin film as a medicament.

Abstract: An electrosurgical instrument configured for connection to a supply apparatus for operation. The instrument has an end opening at the distal end and supports at least one electrode in the area of the end opening to which an alternating voltage potential can be applied. Directly adjoining the end opening, a liner of the electrosurgical instrument limits a flow chamber inside the liner. With distance to the end opening a flushing channel opens out into the flow chamber via an exit opening and a suction channel opens out into the flow chamber via an inlet opening. A flushing fluid can be introduced in the flow chamber via the flushing channel and can be extracted by suction via the suction channel.

Abstract: An electronic communication network comprises a server platform and client data processing devices. Each client data processing device is configured to submit electronic messages to the server platform, provided with a timestamp. The server platform is configured to process incoming electronic messages strictly in a sequence corresponding to the timestamp. The electronic communication network comprising at least one switch, wherein the switch is arranged to receive electronic messages from a plurality of the client data processing devices. the switch comprises a buffer and is configured to store the electronic messages produced by the client data processing devices in the buffer, and to transfer the electronic messages in a manner sorted according to the timestamp provided to each electronic message by the time generator of the client data processing device submitting the electronic message, so that the electronic message with the oldest time is transferred first.

Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.

Abstract: A CO2 beam source includes a discharge tube in which a laser gas serves as a laser medium, a fan for supplying the laser gas into the discharge tube via a supply element and for removing the laser gas from the discharge tube via a removal element in a closed laser gas circuit, and a catalyst for catalysing oxidation of dissociation products formed upon excitation of the laser gas. The catalyst includes precious metal nanoparticles applied to a substrate. The catalyst is arranged with clearance from the discharge tube in the flow direction of the laser gas within the closed laser gas circuit in order to reduce deposition of degradation products formed in the discharge tube upon excitation of the laser gas compared to an arrangement within the discharge tube. A temperature of the at least one catalyst during operation of the CO2 beam source is at least 60° C.

Abstract: An enzymatically catalyzed method for producing L-glufosinate or a phosphoester of L-glufosinate can be performed. An activated L-homoserine HA is reacted with a substrate S selected from methylphosphinic acid and the esters of methylphosphinic acid. The method makes accessible new substrates in the enzymatic production of L-glufosinate and its phosphoesters.

Abstract: The disclosure relates to a motor vehicle and a method for summarizing a conversation in a motor vehicle. The method involves determining by a vehicle sensor device whether a challenging driving task is present; if the challenging driving task is present, masking a conversation in the motor vehicle for a driver by generating counter noise; recording the conversation in the motor vehicle by at least one vehicle microphone; summarizing the conversation by artificial intelligence; outputting a summary of the conversation to the driver after determining that the challenging driving task is no longer present; and deactivating the counter noise after the outputting the summary of the conversation.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A system for actively attenuating acoustic vibrations of a rail for rail traffic is provided including at least one sensor for detecting at least a vertical acoustic vibration of the rail, at least one actuator for exciting at least a vertical counter-vibration of the rail and at least one control unit communicatively connected to the at least one sensor and the at least one actuator for controlling the at least one actuator depending on the vibration detected by the sensor, the counter-vibration being adapted to destructively interfere with the detected vibration, and the at least one actuator being mechanically coupled to the rail and to a carrier element supporting the rail. Also provided is a carrier element for the system and a method for actively attenuating acoustic vibrations of a rail for rail traffic.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: The present invention relates to a method for producing a multi-layer oral thin film comprising the steps of a) providing a solution, an emulsion, a foam or a suspension comprising at least one first polymer, b) processing the solution, the emulsion, the foam or the suspension from step a) in order to obtain a polymer film, c) applying a powder comprising at least one second substance, which preferably differs from the first polymer, to the polymer film, and d) forming a composite between the polymer film and the powder applied in step c), to a multi-layer oral thin film obtainable by this method, and to the use of a multi-layer oral thin film obtainable by this method as a medicament.

Abstract: The present subject matter relates to a connection element for a cooler of a high-voltage accumulator. A coolant supply system extends between a supply interface and a discharge interface. A connection interface connects a heat exchange element of the cooler to the coolant supply system. The supply interface and the discharge interface have congruent interface contours. A cooler element and a cooler for a high-voltage accumulator are also provided.

Abstract: The present invention relates to a multi-layer thin film comprising at least two layers arranged one on top of the other which each comprise at least one polymer, these at least two layers being connected to one another by at least one stitched seam using at least one thread, and to a method for producing such a thin film and to the use thereof as a medicament.

Abstract: A hybrid transmission for a vehicle includes a transmission input shaft extending in a transverse direction, at least one countershaft arranged parallel to the transmission input shaft, a clutch device arranged coaxially with respect to the transmission input shaft and which has at least one clutch, and a differential having a differential input gear. A rotational axis of the differential input gear is arranged parallel to the transmission input shaft. The transmission also includes an electric machine having a rotor with a rotor rotational axis arranged parallel to the transmission input shaft and a transmission control device. As viewed in a longitudinal direction perpendicular to the transverse direction, the differential input gear, the transmission input shaft, and a transmission controller including the transmission control device are arranged in succession in the sequence specified.

Abstract: A disc brake for utility vehicles includes a brake disc, a first brake lining on a first side of the brake disc and a second brake lining on a second side of the brake disc opposite the first side. A spreading device is also provided which generates a force that moves the first and the second brake lining away from one another.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: The invention relates to crystalline folate salts. The salt consists of a folate anion and an organic cation. The folate anion is 5-methyl-(6S)-tetrahydrofolic acid, and the cation is an organic compound which is an alkanolamine selected from the group consisting of choline, N-methylaminoethanol, 2-amino-2-methylpropanol and 2-dimethylaminoethanol.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The disclosed technology relates to a hearing system comprising a first hearing device configured for arrangement in an ear canal of a first ear of a user and a second hearing device configured for arrangement proximate to the first hearing device at the first ear of the user. The first hearing device and the second hearing device may each include a microphone, a signal processing unit, a loudspeaker, and a battery, such that both the first hearing device and the second hearing device are configured to function as a hearing device independently and when combined. In addition, the second hearing device may be configured to charge the battery of the first hearing device.