Abstract: Herein is reported an antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from (1) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 83; or (2) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 83; or (3) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 91; or (4) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 91.

Abstract: The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma- or beta-rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. The invention further relates to a method for preparing said irradiated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such a membrane for the cultivation of cells, in particular adherent cells.

Abstract: The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma- or beta-rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. The invention further relates to a method for preparing said irradiated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such a membrane for the cultivation of cells, in particular adherent cells.

Abstract: A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

Abstract: Herein is reported a method for the recombinant production of a polypeptide in a eukaryotic cell comprising the steps of (i) cultivating a eukaryotic cell comprising a nucleic acid encoding the polypeptide in a cultivation medium comprising a compound selected from the group consisting of trans-2-methyl 2-pentenoic acid, the broad-spectrum HDAC inhibitor Quisinostat, and the subtype-specific HDAC inhibitor Romidepsin, and (ii) recovering the polypeptide from the cell or the cultivation medium and thereby producing the polypeptide in a eukaryotic cell.

Abstract: Herein is reported a method for the recombinant production of a polypeptide in a eukaryotic cell comprising the steps of (i) cultivating a eukaryotic cell comprising a nucleic acid encoding the polypeptide in a cultivation medium comprising a compound selected from the group consisting of trans-2-methyl 2-pentenoic acid, the broad-spectrum HDAC inhibitor Quisinostat, and the subtype-specific HDAC inhibitor Romidepsin, and (ii) recovering the polypeptide from the cell or the cultivation medium and thereby producing the polypeptide in a eukaryotic cell.

Abstract: Herein is reported a method for the recombinant production of a polypeptide in a eukaryotic cell comprising the steps of (i) cultivating a eukaryotic cell comprising a nucleic acid encoding the polypeptide in a cultivation medium comprising a compound selected from the group consisting of trans-2-methyl 2-pentenoic acid, the broad-spectrum HDAC inhibitor Quisinostat, and the subtype-specific HDAC inhibitor Romidepsin, and (ii) recovering the polypeptide from the cell or the cultivation medium and thereby producing the polypeptide in a eukaryotic cell.

Abstract: A hollow machine element for transmitting a force and/or a torque is provided. The hollow machine element forms a component of an assembly for measuring the acting force and/or torque by using inverse magnetostrictive effect. The hollow machine element extends along an axis and has a cavity that extends along the axis. The machine element includes at least one magnetization region for magnetization, and which includes a magnetostrictive material. A magnetic field measurable via the assembly can be caused by the magnetization and by the force and/or by the torque. The magnetization region is directed toward the cavity and has an axially central segment, in which the magnetization region is arranged at a radial distance from a ferromagnetic region of the machine element to define a gap therebetween. The gap may be empty or filled with insulation, to provide magnetic insulation.

Abstract: An arrangement for measuring a force and/or a torque using the inverse-magnetostrictive effect includes a workpiece made from steel as a primary sensor for a measurement of a force and/or a torque using the inverse-magnetostrictive effect. The arrangement includes a machine element on which the force or the torque acts, which causes mechanical stress and the machine element is usually slightly deformed. The machine element is formed of steel and has at least one magnetostrictive area for a magnetization, which forms a primary sensor for measuring the force and/or the torque. The arrangement further includes at least one magnetic field sensor for measuring a magnetic field caused by the magnetization and also by the force and/or by the torque. The magnetic field sensor forms a secondary sensor for measuring the force and/or the torque.

Abstract: A hollow machine element for transmitting a force and/or a torque is provided. The hollow machine element forms a component of an assembly for measuring the acting force and/or torque by using inverse magnetostrictive effect. The hollow machine element extends along an axis and has a cavity that extends along the axis. The machine element includes at least one magnetization region for magnetization, and which includes a magnetostrictive material. A magnetic field measurable via the assembly can be caused by the magnetization and by the force and/or by the torque. The magnetization region is directed toward the cavity and has an axially central segment, in which the magnetization region is arranged at a radial distance from a ferromagnetic region of the machine element to define a gap therebetween. The gap may be empty or filled with insulation, to provide magnetic insulation.

Abstract: A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.

Abstract: A bottom bracket unit including a bottom bracket axle (1), at least one bearing (2, 3) that receives the bottom bracket axle (1) in a rotatable manner, and an optical detection unit (11), by which a rotational speed of the bottom bracket axle (1) can be detected. The optical detection unit (11) measures at least one signaling device (12) that is rotationally fixed to the bottom bracket axle (1). The aim of the invention is to provide a bottom bracket unit that can also detect the rotational direction of the bottom bracket axle in addition to the rotational speed of the axle. This is achieved in that the optical detection unit (11) has two optical sensors (17), with one of these sensors (17) providing a signal that is phase-shifted with respect to the other sensor (24) having a fixed phase difference, in particular with a phase difference of 90°.

Abstract: A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes.

Abstract: A bottom bracket unit including a bottom bracket axle (1), at least one bearing (2, 3) that receives the bottom bracket axle (1) in a rotatable manner, and an optical detection unit (11), by which a rotational speed of the bottom bracket axle (1) can be detected. The optical detection unit (11) measures at least one signaling device (12) that is rotationally fixed to the bottom bracket axle (1). The aim of the invention is to provide a bottom bracket unit that can also detect the rotational direction of the bottom bracket axle in addition to the rotational speed of the axle. This is achieved in that the optical detection unit (11) has two optical sensors (17), with one of these sensors (17) providing a signal that is phase-shifted with respect to the other sensor (24) having a fixed phase difference, in particular with a phase difference of 90°.

Abstract: A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.

Abstract: A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.

Abstract: A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes.

Abstract: The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to modification of the membrane surface with a combination of at least one extracellular matrix protein, at least one extracellular matrix (proteo-) glycan, and at least one heparin-binding growth factor. The invention further relates to a method for preparing said modified or coated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such membrane for the cultivation of cells, in particular adherent cells.

Abstract: A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.

Abstract: A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.