Abstract: A cell culture plate includes one or more cell culture well(s) including at least one barrier for dividing the well into at least two compartments, wherein the barrier includes nanofibrillar cellulose hydrogel, and a method for the preparation thereof. A method for detecting a substance is also disclosed.

Abstract: The present invention is related to methods and materials for culturing expanding cells in a three-dimensional culture. The material comprises plant-derived anionic nanofibrillar cellulose, wherein the anionic nanofibrillar cellulose is in a form of hydrogel. The invention also provides methods for producing materials and compositions comprising plant-derived anionic nanofibrillar cellulose.

Abstract: The invention relates to a method for the manufacture of cellulose carbamate textile fibre, comprising the steps of dissolving cellulose carbamate in an aqueous alkaline medium to form a cellulose carbamate dope comprising zinc; spinning the cellulose carbamate dope into an alkaline aqueous spin bath in a spinning unit, to form filaments or filament tow; and stretching the filaments or filament tow to obtain cellulose carbamate fibres. In the spin bath, sodium hydroxide and sodium carbonate contents are maintained within pre-defined ranges by withdrawing and recycling a portion of the spin bath.

Abstract: The invention relates to a cellulose carbamate polymer having an average intrinsic viscosity of 146 to 368 ml/g, a nitrogen content of 0.01 to 3% by weight, a polydispersity index of 2.0 to 5.0, which has a content of p-terephthalate and/or p-terephthalic acid and/or unhydrolyzed or partly unhydrolyzed polyester of 0.00005 to 0.5% by weight.

Abstract: According to an example aspect of the present invention, there is provided a manmade cellulosic textile fibre having a linear density of 0.8-1.8 dtex, a tenacity of 2.0-2.9 cN/dtex, and an initial modulus of 50-120 cN/dtex. The cellulosic textile fibre comprises a cellulose-based material, wherein at least 50 wt-% of the raw material of the textile fibre is cellulose-containing waste, and at least 50 wt-% of the cellulose-containing waste is textile waste.

Abstract: The present application provides a method for preparing nanofibrillar cellulose product, the method comprising providing nanofibrillar cellulose, providing multivalent cations, contacting the nanofibrillar cellulose with the multivalent cations, and allowing reacting for a period of time to obtain cross-linked nanofibrillar cellulose product. The present application also provides a nanofibrillar cellulose product comprising nanofibrillar cellulose and multivalent cations, wherein the nanofibrillar cellulose is crosslinked by the multivalent cations.

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Abstract: The present disclosure provides a bioreactor for extracting cell-derived products from cultured cells, the bioreactor comprising a container, an inlet for inputting cell culture medium into the container, an outlet for outputting cell culture medium comprising cell-derived products from the container, the container comprising, or being connected to, a compartment comprising nanostructured cellulose configured to receive cells, said compartment comprising a first separating surface separating the nanostructured cellulose from the outlet and allowing cell culture medium comprising cell-derived products to pass through the first separating surface. The present disclosure also provides a method for separating cell-derived products from cultured cells and a nanostructured cellulose product.

Abstract: The present application relates to a method for preparing a medical product, the method comprising providing an aqueous dispersion of nanofibrillar cellulose, providing a nonwoven fabric, immersing the nonwoven fabric in the aqueous dispersion of nanofibrillar cellulose to form a coating on the nonwoven fabric, passing the immersed nonwoven fabric through a prefined gap to define the thickness of the coating on the immersed nonwoven fabric without pressing, and dewatering the immersed nonwoven fabric, to obtain the medical product. The present application also relates to a medical product comprising a supporting layer and an absorbent layer, wherein the supporting layer comprises a nonwoven fabric, and the absorbent layer comprises unpressed nanofibrillar cellulose having an average fibril diameter of 200 nm or less, wherein the absorbent layer is coating the supporting layer.

Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.

Abstract: The present disclosure provides ex vivo tumour immune microenvironment model comprising patient-derived explant with a tumour-specific immune cell profile embedded in a matrix comprising nanofibrillar cellulose hydrogel having a concentration in the range of 0.25-1.2% by weight, wherein the nanofibrillar cellulose comprises fibrils and/or fibril bundles having number-average diameter of 200 nm or less.

Abstract: The present application relates to a method for preparing a pharmaceutical composition, the method comprising providing pharmaceutical compound having a solubility in water of 1 mg/ml or less at 25° C. in a solvent enabling solubilizing the pharmaceutical compound at least partly into the solvent, providing an aqueous dispersion of nanostructured cellulose, and combining the pharmaceutical compound with the aqueous dispersion of nanostructured cellulose in an anti-solvent process to provide nanosized pharmaceutical particles having an average diameter of 50 nm or less, to provide a pharmaceutical composition. The present application also provides pharmaceutical composition, and use of the pharmaceutical composition.

Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the content of nanofibrillar cellulose in the hydrogel is in the range of 1-3.5% (w/w), and the nanofibrillar cellulose comprises anionic nanofibrillar cellulose having an average fibril diameter of 200 nm or less, and to a method for preparing thereof. The present application also relates to the medical hydrogel for use for inducing vascularization in wounds and/or for treating deep wounds of dermis and/or below tissue.

Abstract: A composition or matrix comprising a bacteriophage and nanofibrillar cellulose or a derivative thereof in a wet or dry state is disclosed.

Abstract: The present disclosure provides a method for preparing microbeads comprising nanofibrillar cellulose, the method comprising providing a dispersion of chemically anionically modified nanofibrillar cellulose having a number-average diameter of 200 nm or less, forming the nanofibrillar cellulose into microbeads, to obtain microbeads comprising chemically anionically modified nanofibrillar cellulose in the range of 0.2-2% by weight. The present disclosure also provides the microbeads, a cell culture, a method for providing cell-derived products, use of the microbeads and use of chemically anionically modified nanofibrillar cellulose for preparing the microbeads.

Abstract: The present application provides a method for preparing a medical product for covering tissue, the method comprising providing nanofibrillar cellulose, providing a bioactive molecule, and covalently bonding the bioactive molecule to the nanofibrillar cellulose. The present application also provides a medical product for covering tissue comprising a bioactive molecule covalently bound to nanofibrillar cellulose.

Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa·s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.

Abstract: A method for freeze-drying a hydrogel composition is disclosed, the method comprising providing the hydrogel composition, wherein the hydrogel composition comprises cellulose nanofibrils and/or cellulose nanocrystals, at least one saccharide, at least one amino acid, and biologics; and freeze-drying the hydrogel composition, thereby obtaining a freeze-dried hydrogel composition.

Abstract: The present disclosure relates to a method for controlling freeze-drying of a hydrogel wherein the method comprises adjusting the residual water content of the freeze-dried hydrogel, and to a freeze-dried hydrogel composition comprising nanoscale cellulose and a at least one biomolecule selected from an oligosaccharide or a disaccharide. The present disclosure further concerns the use of the freeze-dried hydrogel composition for cell culturing, a cell culturing scaffold as well as a process for manufacturing a reconstituted hydrogel.

Abstract: The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.