Abstract: The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula: wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.

Abstract: A driving device of a metering and mixing apparatus for multi-component substances is disclosed, which driving device can have at least two cartridge holders for holding interchangeable cartridges with individual substance components, a discharging apparatus for simultaneously discharging the substance components from the cartridges through component outlets with the aid of discharging pistons entering the cartridge holder or cartridges, and a mixing apparatus which is connected to the component outlets, for mixing the discharged substance components and discharging the latter in mixed form, and a transmission unit for the connection of a drive motor, wherein the transmission unit can have a detector for detecting at least one counter pressure which builds up during the discharging of at least one of the substance components, and a controller, which is connected on an inlet side to the detector for bringing about a driving control function in response to a detection result.

Abstract: An application device for multi-component substances, such as adhesives or sealants, having at least two interconnected cartridge receiving devices for receiving replaceable cartridges containing components to be mixed. One cartridge has a rigid outside wall, including a drive device for expelling the components in predetermined quantity ratios through outlets with the aid of pistons. A mixing device, connected to the outlets, mixes the expelled components and discharges them in a mixed state. At least one of the cartridge receiving devices can be loaded with cartridges on the discharge side. At least one of the cartridge receiving devices supports a cartridge having a rigid outside wall. A cover adapter is provided on the discharge side on the at least two cartridge receiving devices, and a cartridge cover is provided to receive or attach the replaceable mixing device.

Abstract: A driving device of a metering and mixing apparatus for multi-component substances is disclosed, which driving device can have at least two cartridge holders for holding interchangeable cartridges with individual substance components, a discharging apparatus for simultaneously discharging the substance components from the cartridges through component outlets with the aid of discharging pistons entering the cartridge holder or cartridges, and a mixing apparatus which is connected to the component outlets, for mixing the discharged substance components and discharging the latter in mixed form, and a transmission unit for the connection of a drive motor, wherein the transmission unit can have a detector for detecting at least one counter pressure which builds up during the discharging of at least one of the substance components, and a controller, which is connected on an inlet side to the detector for bringing about a driving control function in response to a detection result.

Abstract: The disclosure relates to an application device for multi-component substances, such as multi-component adhesives or multi-component sealants, having at least two interconnected cartridge receiving devices for receiving replaceable cartridges containing substance components to be mixed, wherein one of which cartridges has a rigid outside wall, including a drive device for expelling the substance components from the cartridges in predetermined quantity ratios through component outlets with the aid of expulsion pistons, and a mixing device, which is connected to the component outlets, mixes the expelled substance components and discharges them in the mixed state. At least one of the cartridge receiving devices can be designed to be loaded with cartridges on the discharge side, at least one of the cartridge receiving devices being designed to support a cartridge having a rigid outside wall.