Abstract: The invention relates to a tablet having a tablet core comprising a plurality of active ingredient-containing pellets and one or more pharmaceutically tolerated excipients and at least one coating applied to the tablet core, the active ingredient-containing pellets containing hydromorphone or a salt or a solvate thereof as active ingredient and having the following structure: a) an inert core, b) an active ingredient layer applied to the inert core, c) a layer applied to the active ingredient layer and retarding the release of the active ingredient and d) a further active ingredient layer on the layer retarding the release of the active ingredient.

Abstract: The invention relates to solid oral pharmaceutical compositions in the form of pellets, mini-tablets, tablets, or capsules, comprising an optionally substituted 2-(pyridylmethylsulfinyl)-1H-benzimidazole, for example esomeprazole, and carrageenan, and optionally one or more excipients. Surprisingly, it has been found that these compositions are stable and rapidly release the active ingredient. The pellets or mini-tablets may be coated as such, or filled in capsules or pressed into tablets, with a polymer, which dissolves only at a pH value of 5 or higher, optionally over a stabilizing intermediate layer.

Abstract: A non effervescent tablet of ibuprofen, comprising a tablet core and, if desired, a sugar or film coat, wherein the tablet core, based on the weight of the tablet core, consists of 50 to 100% by weight sodium ibuprofen hydrate and 50 to 0% by weight auxiliary material component and contains no lubricant and no disintegrant, and wherein the sodium ibuprofen hydrate has a water content of 8 to 16% by weight, preferably 11 to 16% by weight, possesses a suffcient hardness, is comparably small and leads to a particularly rapid increase in blood level and thereby to an accelerated onset of analgesic effect. Contrary to the current doctrine sodium ibuprofen hydrate having a suitable water content is sufficiently compressible.

Abstract: A non effervescent tablet of ibuprofen, comprising a tablet core and, if desired, a sugar or film coat, wherein the tablet core, based on the weight of the tablet core, consists of 50 to 100% by weight sodium ibuprofen hydrate and 50 to 0% by weight auxiliary material component and contains no lubricant and no disintegrant, and wherein the sodium ibuprofen hydrate has a water content of 8 to 16% by weight, preferably 11 to 16% by weight, possesses a sufficient hardness, is comparably small and leads to a particularly rapid increase in blood level and thereby to an accelerated onset of analgesic effect. Contrary to the current doctrine sodium ibuprofen hydrate having a suitable water content is sufficiently compressible.

Abstract: A process for producing rapidly disintegrating pharmaceutical formulations containing an extract is provided. The process comprises providing a dry powdered extract and a lubricant, compacting the powdered extract with the lubricant, using between about 0.5-10% lubricant by weight. The compacting is done using a device that yields flakes. The flakes are then crushed into granules, and the granules are compressed with conventional excipients such as bulking agents, glidants, disintegrants, flow regulators and other additives into pharmaceutical formulations.