Patents by Inventor Markus-Rene Gold

Markus-Rene Gold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for manufacturing adamantane derivatives with high yield
    Patent number: 8796491
    Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: August 5, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin
  • Method of preparing Neramexane or a salt thereof
    Patent number: 8692021
    Abstract: Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or a pharmaceutically acceptable salt thereof (Neramexane), comprising step (iv): (iv) hydrolyzing a mixture comprising an acid, 1-formamido-1,3,3,5,5-pentamethylcyclohexane and hydrogen cyanide to yield 1-amino-1,3,3,5,5-pentamethylcyclohexane.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 8, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Markus-Rene Gold, Valerjans Kauss, Aigars Jirgensons
  • METHOD OF PREPARING NERAMEXANE OR A SALT THEREOF
    Publication number: 20120245391
    Abstract: Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or a pharmaceutically acceptable salt thereof (Neramexane), comprising step (iv): (iv) hydrolyzing a mixture comprising an acid, 1-formamido-1,3,3,5,5-pentamethylcyclohexane and hydrogen cyanide to yield 1-amino-1,3,3,5,5-pentamethylcyclohexane.
    Type: Application
    Filed: September 24, 2010
    Publication date: September 27, 2012
    Applicant: MERZ PHARMA GmbH &CO. KGaA
    Inventors: Markus-Rene Gold, Valerjans Kauss, Aigars Jirgensons
  • METHOD FOR PRODUCING MEMANTINE
    Publication number: 20110288336
    Abstract: Method for producing 1-amino-3,5-dimethyladamantane or a salt thereof, comprising: (i) heating 1-formamido-3,5-dimethyladamantane with a base in a protic solvent.
    Type: Application
    Filed: December 16, 2009
    Publication date: November 24, 2011
    Applicant: Merz Pharma GmbH & Co. KGaA
    Inventors: Markus-Rene Gold, Aigars Jirgensons, Florian Anton Martin Huber
  • PROCESS FOR PREPARING MEMANTINE
    Publication number: 20110282100
    Abstract: The present invention relates to a process for preparing memantine, or a pharmaceutically acceptable salt thereof (e.g., memantine hydrochloride), which is substantially free of impurities.
    Type: Application
    Filed: January 20, 2010
    Publication date: November 17, 2011
    Applicant: MERZ PHARMA GmbH & Co. KGaA
    Inventors: Gunter Quack, Markus-Rene Gold
  • PROCESS FOR MANUFACTURING ADAMANTANE DERVATIVES WITH HIGH YIELD
    Publication number: 20110263900
    Abstract: The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine:substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.
    Type: Application
    Filed: August 7, 2009
    Publication date: October 27, 2011
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Markus-Rene Gold, Herbert Koller, Michael Pyerin