Abstract: For separating non-conventional transmissible agents (NCTAs), i.e. causative agent(s), of transmissible spongiform encephalopathies (TSEs) from a solution of a protein susceptible to contamination with NCTAs, particularly from blood products, at least one adsorbent is suspended, for a time of at least 10 minutes. The absorbent is selected from kieselguhr, diatomaceous earth, silicic acid, clay minerals, metal hydroxide, metal oxihydrate, cellulose, perlite, bentonite, and water-insoluble synthetic polymers. The obtained suspension is agitated, and subsequently the adsorbent is separated from the protein solution.

Abstract: In the method for producing an immunoglobulin solution suitable for intravenous application with an IgM proportion of more than 5% by weight with respect to the immunoglobulin proportion, an IgM-containing immunoglobulin solution is treated with a protease. The intravenously well tolerated preparation obtained is characterized by not being chemically modified and by having low anticomplementary activity ACA.