Abstract: The invention is related to a hand-operated actuator mechanism for driving a piercing element with increased safety. The actuator mechanism comprises a mounting element connected to a trigger element by a first breakable connection element. It also comprises a piercing element carrier connected to the trigger element by a second breakable connection element. The trigger element further comprises a pushing member that can be pushed with a human finger. The first breakable connection element is configured to be broken by means of a predetermined pushing finger force pushing said pushing member. The piercing element carrier being movable between an initial position wherein the first and the second breakable connection elements are unbroken, and a stop position wherein an abutment stops a movement of the piercing element carrier.

Abstract: According to the invention, a diagnostic testing device is provided that comprises a plurality of detection chambers that are arranged in a geometric pattern. Each detection chamber comprises a receptacle for a sample container (14) containing a sample to be tested for luminescence. The diagnostic testing device further comprises a plurality of sensors, each sensor being assigned to a respective one of the detection chambers, energy supply means, a wireless data interface, a controller and a data memory. The data memory comprises a data structure, for instance a data base, wherein for each detection chamber a plurality of entries are provided that each are assigned to one individual detection chamber.

Abstract: The present invention relates to a fast and optionally multiplexing or multimeric method for isothermal amplification of nucleic acids, including DNA and RNA. Particularly, the invention relates to diagnostic methods for rapidly diagnosing, for example, at least two infectious agents, or at least two different targets in the same infectious agent, in a biological probe of interest. The invention further relates to a handheld and portable diagnostic system for performing the amplification method in a laboratory as well as in a non-laboratory environment. Further provided are suitable enzyme sequences, kits and uses of the method and the system.

Abstract: The invention relates to a system is provided that comprises a lysis chamber, an amplification chamber and a fluorescence detection device. The fluorescence detection device (16) comprises - a detection chamber (42) configured to receive the amplification chamber (14) or the contents of the amplification chamber, - a light source (44), - an optical sensor (46), - energy supply means (48), - a wireless data interface (52) and - a controller (50).

Abstract: A testing assembly for lateral flow assay comprising a liquid sample receiving unit arranged on a support structure defining a plane and configured to receive a liquid sample via the liquid sample receiving interface, at least one testing strip having, in a planar state, a testing strip center line length (L) in a longitudinal direction, a testing strip width in a width direction and a testing strip thickness, and comprising a capillary wick that includes a test portion that comprises a reacting material configured to react in a predetermined manner to a pre-specified analyte, wherein the width direction of the testing strip extends at an angle smaller than 90° with respect to a normal of the plane, and wherein the testing strip is curved, resulting in an effective extension being shorter than the testing strip center line length in the planar state.

Abstract: The invention relates to a system is provided that comprises a first container, a second container and a fluorescence detection device. The first container comprises a first set of chemicals and/or agents and is closed prior to use. The second container comprises a second set of chemicals and/or agents that are at least in part distinct from the chemicals and/or agents of the first set. The first container comprises a lid, that can be opened when the first container and the second container are combined to form a single, fluid tight assembly, in order to allow the contents of the first container to enter the second container.

Abstract: The invention relates to a testing device with a testing assembly for lateral flow assay. The testing assembly comprises liquid sample receiving interface arranged on a support structure defining a plane. The liquid sample receiving interface is configured to receive a liquid sample. The testing assembly comprises at least one testing strip fluidly connected to the liquid sample receiving interface. The testing strip comprises a capillary wick fluidly connected to the liquid sample receiving interface and including at least one test portion, the test portion comprising at least one respective reacting material configured for reacting in a predetermined manner to at least one specific analyte. The testing device comprises an optical sensor, arranged and configured for detecting light reflected from the at least one test portion and for converting the detected light into an electrical signal representing an intensity and/or a color of the detected light.

Abstract: A device for extracting a body fluid and testing a predetermined analyte or property of the fluid is provided. The device comprises a hollow needle having a channel linking a base end and a tip, a collection chamber having an input end in fluid communication with the channel, a testing chamber, a solution chamber and a flow control. The collection chamber comprises a capillary wick configured to transport at least a fraction of the body fluid away from the input end. The testing chamber comprises a testing unit including a reacting material configured to react to a predetermined analyte or property of the fluid and the solution chamber comprises a buffer solution. A flow control is also provided for a transfer of the buffer solution from the solution chamber to the collection chamber and a transfer of the body fluid from the collection chamber to the testing chamber.

Abstract: A testing assembly for lateral flow assay comprising a liquid sample receiving unit arranged on a support structure defining a plane and configured to receive a liquid sample via the liquid sample receiving interface, at least one testing strip having, in a planar state, a testing strip center line length (L) in a longitudinal direction, a testing strip width in a width direction and a testing strip thickness, and comprising a capillary wick that includes a test portion that comprises a reacting material configured to react in a predetermined manner to a pre-specified analyte, wherein the width direction of the testing strip extends at an angle smaller than 90° with respect to a normal of the plane, and wherein the testing strip is curved, resulting in an effective extension being shorter than the testing strip center line length in the planar state.

Abstract: A body fluid extraction device for extracting a body fluid and for testing a predetermined analyte or property of the fluid comprises a hollow needle having a channel linking a base end and a tip in fluid communication, a collection chamber having an input end in fluid communication with the channel, the collection chamber comprising a capillary wick configured to transport at least a fraction of the body fluid away from the input end, a testing chamber comprising a testing unit that includes a reacting material configured to react to a predetermined analyte or property of the body fluid, a solution chamber, comprising a buffer solution and flow control means configured to control, a first transfer of the buffer solution from the solution chamber to the collection chamber, and a second transfer of the body fluid from the collection chamber to the testing chamber.

Abstract: A package including optical components has one or more structures with optical input or optical output. An optical interconnection optically connects to the optical input or optical output of the structure(s). A component is provided in which the optical interconnection and the optical input or optical output of the structure(s) are embedded. The component is made of a first material and the optical interconnection of a second material. The first and second materials are chemically identical. The first material has a first primary and/or secondary structure and the second material has a second primary and/or secondary structure. The first primary and/or secondary structure is different from the second primary and/or secondary structure. The refractive indices of the component and of the optical interconnection differ from each other by at least 0.0004 at 850 nm, 1,310 nm, and 1,550 nm, respectively. The optical interconnection is mechanically fixed by the component.

Abstract: A package including optical components has one or more structures with optical input or optical output. An optical interconnection optically connects to the optical input or optical output of the structure(s). A component is provided in which the optical interconnection and the optical input or optical output of the structure(s) are embedded. The component is made of a first material and the optical interconnection of a second material. The first and second materials are chemically identical. The first material has a first primary and/or secondary structure and the second material has a second primary and/or secondary structure. The first primary and/or secondary structure is different from the second primary and/or secondary structure. The refractive indices of the component and of the optical interconnection differ from each other by at least 0.0004 at 850 nm, 1,310 nm, and 1,550 nm, respectively. The optical interconnection is mechanically fixed by the component.

Abstract: The present invention is directed to a package including optical components, comprising: (i) at least one structure, the structure having at least one optical input or output, (ii) at least one optical interconnection, optically connected to the at least one optical input or output, and (iii) a component in which the at least one optical interconnection and the at least one optical input or output is embedded, wherein (a) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the at least one optical interconnection (ii) are made from a chemically identical material, wherein the material of the at least one optical interconnection has a different primary and/or secondary structure, compared to the material of the component embedding the at least one optical interconnection and the at least one optical input or output, (b) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the a

Abstract: As described herein, the inventors have identified gene signatures which permit the identification of patients who will benefit from (e.g. have optimal outcomes) cytoreductive surgery as treatment for ovarian cancer. Accordingly, provided herein are methods of treatment, assays, and systems relating to ovarian cancer and the administration of cytoreductive surgery. In one aspect, the technology described herein relates to a method of treatment comprising, detecting, in a sample obtained from a subject in need of treatment for ovarian cancer, the level of activation of at least one pathway, and administering cytoreductive surgery to the subject if the level of activation is not increased relative to a reference level.

Abstract: The present invention is directed to a package including optical components, comprising: (i) at least one structure, the structure having at least one optical input or output, (ii) at least one optical interconnection, optically connected to the at least one optical input or output, and (iii) a component in which the at least one optical interconnection and the at least one optical input or output is embedded, wherein (a) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the at least one optical interconnection (ii) are made from a chemically identical material, wherein the material of the at least one optical interconnection has a different primary and/or secondary structure, compared to the material of the component embedding the at least one optical interconnection and the at least one optical input or output, (b) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the a

Abstract: A method for embedding at least one component into a dielectric layer. obtain a good result, it is provided that the method includes the following steps: a) Position and affix the at least one component on a carrier; b) Cast a liquid dielectric around the at least one component, thereby enclosing the at least one component completely; c) Harden the liquid dielectric to form a solid dielectric layer; and d) Apply, in particular by lamination thereon, another layer, in particular an electrically conductive layer. The use of a dielectric layer formed entirely of liquid dielectric, wherein the liquid dielectric is not converted into a solid state until the dielectric is processed.

Abstract: A method for fixing an electronic component on a printed circuit board, and contact-connecting the electronic component to the printed circuit board, the following steps are provided:—providing the printed circuit board having a plurality of contact and connection pads,—providing the electronic component having a number of contact and connection locations corresponding to the plurality of contact and connection pads, with a mutual spacing reduced in comparison with the spacing of the contact and connection pads, and—arranging or forming at least one interlayer for routing the contact and connection locations of the electronic component between the contact and connection pads and the contact and connection locations of the electronic component. A method for producing an interlayer for routing and a system having a printed circuit board and an electronic component using the interlayer for routing are also provided.

Abstract: A printed circuit board element (1) with a substrate (2), with at least one optoelectronic component (3) embedded in a photopolymerizable optical layer material (5), and with at least one optical waveguide (6) optically coupled with the former and structured in the optical material by photon absorption, wherein a prefabricated deflection mirror (4) embedded in the optical material (5) and optically coupled with the optoelectronic component (3) via the optical waveguide (6) is arranged on the substrate (2), optionally together with a support (4?).

Abstract: The invention relates to a printed circuit board element (10) including at least one optoelectronic component (1) which is embedded in an optical, photopolymerizable layer material (13), and at least one optical waveguide (14) optically coupled thereto, which is structured in the optical, photopolymerizable material (13) by photon irradiation, wherein the component (1) comprises a curved deflection mirror (5) on its light transmission surface (3), which curved deflection mirror deflects the light radiation (15), for instance by 90°.

Abstract: A method for embedding at least one component into a dielectric layer. obtain a good result, it is provided that the method includes the following steps: a) Position and affix the at least one component on a carrier; b) Cast a liquid dielectric around the at least one component, thereby enclosing the at least one component completely; c) Harden the liquid dielectric to form a solid dielectric layer; and d) Apply, in particular by lamination thereon, another layer, in particular an electrically conductive layer. The use of a dielectric layer formed entirely of liquid dielectric, wherein the liquid dielectric is not converted into a solid state until the dielectric is processed.