Abstract: A method is provided for controlling a drive device of a working machine having a motor (11), at least one lockable differential (21, 31, 32, 33), a brake mechanism (14), and a sensor setup. The sensor setup is designed to detect operating parameters, including a braking power of the brake mechanism (14). The method entails braking (I) the working machine by means of the brake mechanism (14), detecting (II) the braking power of the brake mechanism (14), locking (III) the at least one differential (21, 31, 32, 33) if a locking condition is met, which condition is at least met if the braking power reaches or exceeds a locking threshold value (x), and unlocking (IV) the at least one differential (21, 31, 32, 33) if an unlocking condition is met, which condition is at least met if the braking power reaches or falls below an unlocking threshold value (y).

Abstract: A method is provided for controlling a drive device for a working machine having an engine for providing a driving force. The working machine has at least one lockable longitudinal differential for distributing the drive force of the engine to at least two lockable transverse differentials, a sensor device for detecting operating parameters that include rotational speeds of the output elements of the transverse differentials. A differential speed between the speeds of the output elements of each of the transverse differentials is determined and the longitudinal differential is locked when a longitudinal differential lock condition is met by at least one of the differential speeds reaching or exceeding a lock threshold value.

Abstract: A method for controlling a differential gear of a vehicle having articulated steering includes reading in (S1a) temporally successive steering angles of the articulated steering, determining (S2) a steering angle change based on the read-in steering angles, and setting (S3) a wheel speed correction value for a wheel of the vehicle based on the determined steering angle change. The method further comprises determining (S5) a corrected wheel speed of the wheel by applying (S4) the set wheel speed correction value to a wheel speed of the wheel, and outputting (S6) a control command to the differential gear to change an operating state of the differential gear based on the determined corrected wheel speed. A control device for controlling a differential gear of a vehicle having articulated steering can be configured to perform the method. A vehicle can include such a control device.

Abstract: A method is provided for controlling a drive device of a working machine having a motor (11), at least one at least partially lockable transverse differential (31, 32, 33), and a sensor setup. The sensor setup is configured to detect operating parameters, including a rotation speed of the output elements of the at least one transverse differential (31, 32, 33). The method includes locking (I) the transverse differential (31, 32, 33) if a locking condition has been met, determining (II) a rotation speed difference (dn) of the output elements of the at least partially locked transverse differential (31, 32, 33), and unlocking (III) the transverse differential (31, 32, 33) if an unlocking condition has been met, which is at least met if the rotation speed difference (dn) in an at least partially locked condition of the transverse differential (31, 32, 33) reaches or exceeds an unlocking threshold value (y1).

Abstract: According to the invention, a diagnostic testing device is provided that comprises a plurality of detection chambers that are arranged in a geometric pattern. Each detection chamber comprises a receptacle for a sample container (14) containing a sample to be tested for luminescence. The diagnostic testing device further comprises a plurality of sensors, each sensor being assigned to a respective one of the detection chambers, energy supply means, a wireless data interface, a controller and a data memory. The data memory comprises a data structure, for instance a data base, wherein for each detection chamber a plurality of entries are provided that each are assigned to one individual detection chamber.

Abstract: The invention relates to a liquid sampling device a support structure having a liquid reception interface that is in fluid communication with a reservoir chamber and a microfluidic valve, the microfluidic valve being connected to a measuring chamber. The liquid reception interface, the reservoir chamber and the microfluidic valve are configured to allow liquid entering the liquid reception interface to flow into the reservoir chamber while being prevented from passing the microfluidic valve unless a predetermined static pressure difference over the microfluidic valve is exceeded. The microfluidic valve is a passive valve without moving parts. Passing of liquid through the microfluidic valve is controlled by a static pressure difference over the microfluidic valve.

Abstract: The present invention relates to a fast and reliable method for protected isothermal nucleic acids amplification (PINA) of DNA and RNA. Particularly, the invention relates to diagnostic methods for rapidly diagnosing, for example, an infectious agent, in a biological probe of interest. Particularly, the methods are suitable to be performed on a handheld and portable diagnostic system for performing the amplification method in a non-laboratory environment (“home-test”).

Abstract: The invention is related to a hand-operated actuator mechanism for driving a piercing element with increased safety. The actuator mechanism comprises a mounting element connected to a trigger element by a first breakable connection element. It also comprises a piercing element carrier connected to the trigger element by a second breakable connection element. The trigger element further comprises a pushing member that can be pushed with a human finger. The first breakable connection element is configured to be broken by means of a predetermined pushing finger force pushing said pushing member. The piercing element carrier being movable between an initial position wherein the first and the second breakable connection elements are unbroken, and a stop position wherein an abutment stops a movement of the piercing element carrier.

Abstract: According to the invention, a diagnostic testing device is provided that comprises a plurality of detection chambers that are arranged in a geometric pattern. Each detection chamber comprises a receptacle for a sample container (14) containing a sample to be tested for luminescence. The diagnostic testing device further comprises a plurality of sensors, each sensor being assigned to a respective one of the detection chambers, energy supply means, a wireless data interface, a controller and a data memory. The data memory comprises a data structure, for instance a data base, wherein for each detection chamber a plurality of entries are provided that each are assigned to one individual detection chamber.

Abstract: The present invention relates to a fast and optionally multiplexing or multimeric method for isothermal amplification of nucleic acids, including DNA and RNA. Particularly, the invention relates to diagnostic methods for rapidly diagnosing, for example, at least two infectious agents, or at least two different targets in the same infectious agent, in a biological probe of interest. The invention further relates to a handheld and portable diagnostic system for performing the amplification method in a laboratory as well as in a non-laboratory environment. Further provided are suitable enzyme sequences, kits and uses of the method and the system.

Abstract: The invention relates to a system is provided that comprises a lysis chamber, an amplification chamber and a fluorescence detection device. The fluorescence detection device (16) comprises - a detection chamber (42) configured to receive the amplification chamber (14) or the contents of the amplification chamber, - a light source (44), - an optical sensor (46), - energy supply means (48), - a wireless data interface (52) and - a controller (50).

Abstract: A testing assembly for lateral flow assay comprising a liquid sample receiving unit arranged on a support structure defining a plane and configured to receive a liquid sample via the liquid sample receiving interface, at least one testing strip having, in a planar state, a testing strip center line length (L) in a longitudinal direction, a testing strip width in a width direction and a testing strip thickness, and comprising a capillary wick that includes a test portion that comprises a reacting material configured to react in a predetermined manner to a pre-specified analyte, wherein the width direction of the testing strip extends at an angle smaller than 90° with respect to a normal of the plane, and wherein the testing strip is curved, resulting in an effective extension being shorter than the testing strip center line length in the planar state.

Abstract: The invention relates to a system is provided that comprises a first container, a second container and a fluorescence detection device. The first container comprises a first set of chemicals and/or agents and is closed prior to use. The second container comprises a second set of chemicals and/or agents that are at least in part distinct from the chemicals and/or agents of the first set. The first container comprises a lid, that can be opened when the first container and the second container are combined to form a single, fluid tight assembly, in order to allow the contents of the first container to enter the second container.

Abstract: The invention relates to a testing device with a testing assembly for lateral flow assay. The testing assembly comprises liquid sample receiving interface arranged on a support structure defining a plane. The liquid sample receiving interface is configured to receive a liquid sample. The testing assembly comprises at least one testing strip fluidly connected to the liquid sample receiving interface. The testing strip comprises a capillary wick fluidly connected to the liquid sample receiving interface and including at least one test portion, the test portion comprising at least one respective reacting material configured for reacting in a predetermined manner to at least one specific analyte. The testing device comprises an optical sensor, arranged and configured for detecting light reflected from the at least one test portion and for converting the detected light into an electrical signal representing an intensity and/or a color of the detected light.

Abstract: A device for extracting a body fluid and testing a predetermined analyte or property of the fluid is provided. The device comprises a hollow needle having a channel linking a base end and a tip, a collection chamber having an input end in fluid communication with the channel, a testing chamber, a solution chamber and a flow control. The collection chamber comprises a capillary wick configured to transport at least a fraction of the body fluid away from the input end. The testing chamber comprises a testing unit including a reacting material configured to react to a predetermined analyte or property of the fluid and the solution chamber comprises a buffer solution. A flow control is also provided for a transfer of the buffer solution from the solution chamber to the collection chamber and a transfer of the body fluid from the collection chamber to the testing chamber.

Abstract: A testing assembly for lateral flow assay comprising a liquid sample receiving unit arranged on a support structure defining a plane and configured to receive a liquid sample via the liquid sample receiving interface, at least one testing strip having, in a planar state, a testing strip center line length (L) in a longitudinal direction, a testing strip width in a width direction and a testing strip thickness, and comprising a capillary wick that includes a test portion that comprises a reacting material configured to react in a predetermined manner to a pre-specified analyte, wherein the width direction of the testing strip extends at an angle smaller than 90° with respect to a normal of the plane, and wherein the testing strip is curved, resulting in an effective extension being shorter than the testing strip center line length in the planar state.

Abstract: A body fluid extraction device for extracting a body fluid and for testing a predetermined analyte or property of the fluid comprises a hollow needle having a channel linking a base end and a tip in fluid communication, a collection chamber having an input end in fluid communication with the channel, the collection chamber comprising a capillary wick configured to transport at least a fraction of the body fluid away from the input end, a testing chamber comprising a testing unit that includes a reacting material configured to react to a predetermined analyte or property of the body fluid, a solution chamber, comprising a buffer solution and flow control means configured to control, a first transfer of the buffer solution from the solution chamber to the collection chamber, and a second transfer of the body fluid from the collection chamber to the testing chamber.

Abstract: A package including optical components has one or more structures with optical input or optical output. An optical interconnection optically connects to the optical input or optical output of the structure(s). A component is provided in which the optical interconnection and the optical input or optical output of the structure(s) are embedded. The component is made of a first material and the optical interconnection of a second material. The first and second materials are chemically identical. The first material has a first primary and/or secondary structure and the second material has a second primary and/or secondary structure. The first primary and/or secondary structure is different from the second primary and/or secondary structure. The refractive indices of the component and of the optical interconnection differ from each other by at least 0.0004 at 850 nm, 1,310 nm, and 1,550 nm, respectively. The optical interconnection is mechanically fixed by the component.

Abstract: A package including optical components has one or more structures with optical input or optical output. An optical interconnection optically connects to the optical input or optical output of the structure(s). A component is provided in which the optical interconnection and the optical input or optical output of the structure(s) are embedded. The component is made of a first material and the optical interconnection of a second material. The first and second materials are chemically identical. The first material has a first primary and/or secondary structure and the second material has a second primary and/or secondary structure. The first primary and/or secondary structure is different from the second primary and/or secondary structure. The refractive indices of the component and of the optical interconnection differ from each other by at least 0.0004 at 850 nm, 1,310 nm, and 1,550 nm, respectively. The optical interconnection is mechanically fixed by the component.

Abstract: The present invention is directed to a package including optical components, comprising: (i) at least one structure, the structure having at least one optical input or output, (ii) at least one optical interconnection, optically connected to the at least one optical input or output, and (iii) a component in which the at least one optical interconnection and the at least one optical input or output is embedded, wherein (a) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the at least one optical interconnection (ii) are made from a chemically identical material, wherein the material of the at least one optical interconnection has a different primary and/or secondary structure, compared to the material of the component embedding the at least one optical interconnection and the at least one optical input or output, (b) the component (iii) embedding the at least one optical interconnection and the at least one optical input or output and the a