Patents by Inventor Markus Ruehle

Markus Ruehle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates
    Patent number: 9011864
    Abstract: Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: April 21, 2015
    Assignees: Biotest AG, Immunogen, Inc.
    Inventors: Gregor Schulz, Christoph Bruecher, Frank Osterroth, Steffen Zeng, Christoph Uherek, Silke Aigner, Benjamin Daelken, Markus Ruehle, Elmar Kraus
  • METHOD OF DECREASING CYTOTOXIC SIDE-EFFECTS AND IMPROVING EFFICACY OF IMMUNOCONJUGATES
    Publication number: 20090181038
    Abstract: Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.
    Type: Application
    Filed: December 23, 2008
    Publication date: July 16, 2009
    Inventors: Gregor Schulz, Christoph Bruecher, Frank Osterroth, Steffen Zeng, Christoph Uherek, Silke Aigner, Benjamin Daelken, Markus Ruehle, Elmar Kraus
  • Linkage for a driver's cab
    Patent number: 7140669
    Abstract: For the creation of a retainer is created between the driver's cab and the frame of a vehicle with a spring-loaded support that permits the displacement driver's cab, and with a connecting element by way of which the driver-side support connects to the frame, such retainer to ensure highest possible occupant safety as well as the safety of third parties while permitting low-cost production, a catch plate is proposed one end of which is attached to the connecting element while its other end is attached to the frame is proposed.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: November 28, 2006
    Assignee: DaimlerChrysler AG
    Inventors: Walter Bollinger, Spencer Mckellip, Markus Ruehle
  • Linkage for a driver's cab
    Publication number: 20050225119
    Abstract: A retainer is created between the driver's cab and the frame of a vehicle with a spring-loaded support that permits the displacement of the driver's cab, and with a connecting element by way of which the driver-side support connects to the frame. In order for such retainer to ensure highest possible occupant safety as well as the safety of third parties while permitting low-cost production, a catch plate having one end is attached to the connecting element and its other end is attached to the frame is proposed.
    Type: Application
    Filed: March 19, 2003
    Publication date: October 13, 2005
    Inventors: Walter Bollinger, Spencer Mckellip, Markus Ruehle