Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.

Abstract: A hydraulic system (1) for an industrial truck, in particular an electrically operated, battery-powered industrial truck, includes a lift drive (2) to raise and lower a load handling device. The hydraulic system (1) has a first hydraulic pump (5) which is configured to supply the lift drive (2) with hydraulic fluid, and a second hydraulic pump (6) which can be switched on by means of a valve device (7) for the supply of the lift drive (2). The first hydraulic pump (5) and the second hydraulic pump (6) are configured as a hydraulic double pump unit (1) and the valve device (7) is integrated into the hydraulic double pump unit (10).

Abstract: A hydraulic system for an industrial truck with a lifting frame has at least one telescoping mast that can be raised and lowered in a stationary mast and a load handling means that can be raised and lowered in the telescoping mast. The hydraulic system has a free lift cylinder for raising and lowering the load handling means and at least one mast lift cylinder for raising and lowering the telescoping mast. A control valve device is provided for the control of the lifting operation and the lowering operation of the free lift cylinder and of the mast lift cylinders. A mast transition damping device is provided that includes at least one electrically actuated proportional valve. The proportional valve of the mast transition damping device, in the unactuated state, has a throttling connection that effects a throttled volume flow, and in the event of an electrical control action, can be actuated toward an open position.

Abstract: A method for producing an objective substance, such as phytosphingosine (PHS) and phytoceramide (PHC), comprising a desired alkyl chain using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing a fatty acid.

Abstract: A method for producing an objective substance such as phytosphingosine (PHS) and phytoceramide (PHC) using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activity of a protein(s) encoded by NEM1 and/or SPO7 gene(s) is reduced in a culture medium.

Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: The invention relates to a hydraulic control system of a hoist drive of a lifting frame of an industrial truck, wherein the control system has a directional control valve device which is connected with a delivery line of a hydraulic pump, a reservoir line leading to a reservoir and a connecting line leading to the hoist drive, wherein the directional control valve device is configured to control the lifting operation and the lowering operation of the hoist drive. The control system has a pressure protection valve that is associated with the connecting line, wherein the pressure protection valve is configured to limit a peak pressure introduced into the lifting frame in the event of a fault scenario of the directional control valve device.

Abstract: The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ ID NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.

Abstract: A hydraulic system (1) for an industrial truck, in particular an electrically operated, battery-powered industrial truck, includes a lift drive (2) to raise and lower a load handling device. The hydraulic system (1) has a first hydraulic pump (5) which is configured to supply the lift drive (2) with hydraulic fluid, and a second hydraulic pump (6) which can be switched on by means of a valve device (7) for the supply of the lift drive (2). The first hydraulic pump (5) and the second hydraulic pump (6) are configured as a hydraulic double pump unit (1) and the valve device (7) is integrated into the hydraulic double pump unit (10).

Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.

Abstract: Methods and apparatuses for designing optical systems are provided. In this case, on a plurality of known optical systems, machine learning is carried out in order to train a computing device. After this training, the computing device can generate a design for an optical system on the basis of parameters describing desired properties of an optical system.

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.

Abstract: A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.

Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.

Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.

Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding a NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding a NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.

Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.

Abstract: An imaging optical unit for projection lithography has a plurality of mirrors for guiding imaging light from an object field into an image field. The object field is spanned by two object field coordinates, with a normal coordinate being perpendicular thereto. Imaging light propagates in a first imaging light plane through at least one first plane intermediate image of the imaging optical unit. In a second imaging light plane, the imaging light propagates through at least one second plane intermediate image of the imaging optical unit. The number of first plane intermediate images and the number of second plane intermediate images differ from one another. An imaging optical unit with reduced production costs emerges.

Abstract: A projection optical unit images an object field in an image field. The projection optical unit includes a plurality of mirrors guides imaging light from the object field to the image field. At least two of the mirrors are arranged directly behind one another in the beam path of the imaging light for grazing incidence with an angle of incidence of the imaging light which is greater than 60°. This results in an imaging optical unit that can exhibit a well-corrected imageable field with, at the same time, a high imaging light throughput.