Abstract: This disclosure relates to an optical module comprising an optical element for a working wavelength range in the ultraviolet wavelength range and a holder, wherein the optical element is bonded to the holder by irradiation of an adhesive curable at a curing wavelength range in the ultraviolet wavelength range, and wherein the module has a protective adhesive coating, wherein the protective adhesive coating is multi-layered and is highly reflective and slightly absorbent in the working wavelength range. Furthermore, an optical module is proposed in which the adhesive protective coating that absorbs at the working wavelength has an anti-reflective coating, as well as an optical module that has a diffractive structure in the region of the adhesive.

Abstract: A chromatically corrected imaging illumination optical unit serves for use in a lithographic projection exposure apparatus, for example for imaging, in a manner adapted to a downstream projection optical unit, an illumination conditioning field via an imaging beam path into an object field of the downstream projection optical unit. The illumination optical unit has at least seven and at most twelve lens elements in the imaging beam path. The illumination optical unit has an overall transmission for illumination light of at least 85%. Such an illumination optical unit can be used to improve a throughput of a projection exposure apparatus equipped therewith and achieve a high illumination quality.

Abstract: The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ IN NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.

Abstract: A hydraulic system for an industrial truck with a lifting frame has at least one telescoping mast that can be raised and lowered in a stationary mast and a load handling means that can be raised and lowered in the telescoping mast. The hydraulic system has a free lift cylinder for raising and lowering the load handling means and at least one mast lift cylinder for raising and lowering the telescoping mast. A control valve device is provided for the control of the lifting operation and the lowering operation of the free lift cylinder and of the mast lift cylinders. A mast transition damping device is provided that includes at least one electrically actuated proportional valve. The proportional valve of the mast transition damping device, in the unactuated state, has a throttling connection that effects a throttled volume flow, and in the event of an electrical control action, can be actuated toward an open position.

Abstract: An imaging EUV optical unit serves for imaging an object field into an image field. The optical unit has a plurality of mirrors for guiding EUV imaging light at a wavelength shorter than 30 nm along an imaging beam path from the object field to the image field. The plurality of the mirrors includes at least two normal incidence mirrors and at least two grazing incidence mirrors. An overall transmission of the plurality of the mirrors is greater than 10%. This yields an imaging EUV optical unit whose usability for an EUV projection exposure apparatus can be improved.

Abstract: An illumination system for a microlithography projection illumination facility for illuminating a sample arranged in a region of an object plane of a downstream projection lens with illumination light generated from light from a primary light source is a double-field illumination system for receiving a single light beam coming from the primary light source and generating therefrom two illumination beams. A first illumination beam is guided along a first illumination beam path to a first illumination field outside the optical axis of the projection lens in the exit plane of the illumination system. At the same time, a second illumination beam is guided along a second illumination beam path to a second illumination field opposite the first illumination field relative to the optical axis and outside the optical axis in the exit plane.

Abstract: A catadioptric projection objective for reproducing a pattern arranged in an object plane of the projection objective in an image plane of the projection objective parallel to the object plane comprises a plurality of optical elements comprises lenses and concave mirrors arranged between the object plane and the image plane along an optical axis. The projection objective is a double-field projection objective to reproduce a first effective object field outside the optical axis in the object plane along a first projection beam path in a first effective image field outside the optical axis in the image plane and at the same time to reproduce a second effective object field, opposite the first object field in relation 10 to the first optical axis, outside the optical axis in the object plane along a second projection beam path in a second effective image field outside the optical axis in the image plane.

Abstract: The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ ID NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.

Abstract: In a spectacle lens of a display device the coupling-in portion has an entry surface which is wider in the first direction than the image of the imager, and it is possible to adjust the entry surface coupling-in position at which the image is coupled in via the entry surface in the first direction. The coupling-in position determines the coupling-out direction of the coupling-out portion of the spectacle lens, and therefore the position of the exit pupil in the first direction such that the distance between the exit pupil and the coupling-in portion in the first direction can be adjusted. Irrespective of the coupling-in position, when the deflecting structure causes a deflection, the deflecting structure is always utilized across the entire predetermined extension in the first direction.

Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors.

Abstract: A hydraulic system (1) for an industrial truck, in particular an electrically operated, battery-powered industrial truck, includes a lift drive (2) to raise and lower a load handling device. The hydraulic system (1) has a first hydraulic pump (5) which is configured to supply the lift drive (2) with hydraulic fluid, and a second hydraulic pump (6) which can be switched on by means of a valve device (7) for the supply of the lift drive (2). The first hydraulic pump (5) and the second hydraulic pump (6) are configured as a hydraulic double pump unit (1) and the valve device (7) is integrated into the hydraulic double pump unit (10).

Abstract: A hydraulic system for an industrial truck with a lifting frame has at least one telescoping mast that can be raised and lowered in a stationary mast and a load handling means that can be raised and lowered in the telescoping mast. The hydraulic system has a free lift cylinder for raising and lowering the load handling means and at least one mast lift cylinder for raising and lowering the telescoping mast. A control valve device is provided for the control of the lifting operation and the lowering operation of the free lift cylinder and of the mast lift cylinders. A mast transition damping device is provided that includes at least one electrically actuated proportional valve. The proportional valve of the mast transition damping device, in the unactuated state, has a throttling connection that effects a throttled volume flow, and in the event of an electrical control action, can be actuated toward an open position.

Abstract: A method for producing an objective substance such as phytosphingosine (PHS) and phytoceramide (PHC) using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activity of a protein(s) encoded by NEM1 and/or SPO7 gene(s) is reduced in a culture medium.

Abstract: A method for producing an objective substance, such as phytosphingosine (PHS) and phytoceramide (PHC), comprising a desired alkyl chain using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing a fatty acid.

Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.

Abstract: The invention relates to a hydraulic control system of a hoist drive of a lifting frame of an industrial truck, wherein the control system has a directional control valve device which is connected with a delivery line of a hydraulic pump, a reservoir line leading to a reservoir and a connecting line leading to the hoist drive, wherein the directional control valve device is configured to control the lifting operation and the lowering operation of the hoist drive. The control system has a pressure protection valve that is associated with the connecting line, wherein the pressure protection valve is configured to limit a peak pressure introduced into the lifting frame in the event of a fault scenario of the directional control valve device.

Abstract: The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ ID NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.

Abstract: A hydraulic system (1) for an industrial truck, in particular an electrically operated, battery-powered industrial truck, includes a lift drive (2) to raise and lower a load handling device. The hydraulic system (1) has a first hydraulic pump (5) which is configured to supply the lift drive (2) with hydraulic fluid, and a second hydraulic pump (6) which can be switched on by means of a valve device (7) for the supply of the lift drive (2). The first hydraulic pump (5) and the second hydraulic pump (6) are configured as a hydraulic double pump unit (1) and the valve device (7) is integrated into the hydraulic double pump unit (10).

Abstract: Methods and apparatuses for designing optical systems are provided. In this case, on a plurality of known optical systems, machine learning is carried out in order to train a computing device. After this training, the computing device can generate a design for an optical system on the basis of parameters describing desired properties of an optical system.