Patents by Inventor Markus Storr
Markus Storr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150111194Abstract: A separation material includes a saccharide bound via a linker to a matrix for enabling the separation from a liquid of substances that selectively bind to saccharide moieties. A method for preparing the material, a method for separating from a liquid substances that selective bind to saccharides, and a device including the separation material are also disclosed.Type: ApplicationFiled: August 7, 2012Publication date: April 23, 2015Applicant: GAMBRO LUNDIA ABInventors: Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Manuela Klotz, Sandra Homeyer, Torsten Knoer
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Publication number: 20150110887Abstract: The present disclosure relates to a hemodialysis membrane for the treatment of vascular calcification in hemodialysis patients, especially in chronic hemodialysis patients. The present disclosure further relates to methods of treating vascular calcification in hemodialysis patients, wherein the hemodialysis membrane is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a MWCO of between 170-320 kD or that the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a MWRO of between 8.5 kD and 14.0 kD and a MWCO of between 55 kD and 130 kD.Type: ApplicationFiled: October 10, 2014Publication date: April 23, 2015Inventors: Markus Storr, Bernd Krause, Ralf Schindler, Daniel Zickler, Bjoern Hegner
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Publication number: 20140326669Abstract: Synthetic membranes for the removal, isolation or purification of substances from a liquid. The membranes include at least one hydrophobic polymer and at least one hydrophilic polymer. 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 ?m are entrapped. The membrane has a wall thickness of below 150 ?m. Methods for preparing the membranes in various geometries, and use of the membranes for the adsorption, isolation and/or purification of substances from a liquid are explored.Type: ApplicationFiled: December 10, 2012Publication date: November 6, 2014Inventors: Ralf Flieg, Markus Storr, Bernd Krause, Markus Hornung, Karl Heinz Klotz
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Publication number: 20140166580Abstract: A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.Type: ApplicationFiled: August 7, 2012Publication date: June 19, 2014Applicant: GAMBRO LUNDIA ABInventors: Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Sandra HOMEYER, Torsten KNOER
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Patent number: 8748538Abstract: Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.Type: GrantFiled: March 9, 2011Date of Patent: June 10, 2014Assignee: Gambro Lundia ABInventors: Bernd Krause, Hermann Goehl, Markus Storr, Ralf Menda, Hans-Georg Herz, Joerg Williardt
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Patent number: 8657775Abstract: The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.Type: GrantFiled: September 1, 2009Date of Patent: February 25, 2014Assignee: Gambro Lundis ABInventors: Colin Hutchison, Paul Cockwell, Hermann Göhl, Bernd Krause, Markus Storr
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Publication number: 20130137784Abstract: Graft copolymers of hydrophobic polymers and hydrophilic polymers, a method for their preparation, and their use in membranes for medical treatments such as hemodialysis, hemodiafiltration and hemofiltration, in membranes for water purification, and in membranes for bioprocessing.Type: ApplicationFiled: March 9, 2011Publication date: May 30, 2013Applicant: GAMBRO LUNDIA ABInventors: Bernd Krause, Hermann Goehl, Markus Storr, Ralf Menda, Hans-Georg Herz, Joerg Williardt
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Publication number: 20120305486Abstract: A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.Type: ApplicationFiled: April 13, 2011Publication date: December 6, 2012Applicant: GAMBRO LUNDIA ABInventors: Markus Storr, Bernd Krause, Hermann Goehl, Thomas Ertl, Alexander Gekeler
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Patent number: 8303819Abstract: A separating material formed by a solid substrate having a substrate surface, primary or secondary amines coupled to the substrate surface, and a graft polymer formed on the substrate by covalently coupling the primary or secondary amines with a thermally labile radical initiator and subsequently contacting the substrate surface with a solution of one or more polymerizable monomers. Methods for the extracorporeal treatment of blood, blood plasma or blood serum employing the separating material, for affinity adsorption, ion-exchange adsorption, hydrophobic adsorption, or hydrophilic adsorption employing the separating material, and a separating column employing the separating material are also disclosed.Type: GrantFiled: February 16, 2012Date of Patent: November 6, 2012Assignee: Gambro Lundia ABInventors: Markus Storr, Egbert Muller, Wolfgang Freudemann
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Publication number: 20120208256Abstract: An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups.Type: ApplicationFiled: October 20, 2010Publication date: August 16, 2012Applicant: GAMBRO LUNDIA ABInventors: Ralf Flieg, Manuela Klotz, Markus Storr, Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Bernd Krause, Markus Hornung
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Publication number: 20120160771Abstract: A separating material formed by a solid substrate having a substrate surface, primary or secondary amines coupled to the substrate surface, and a graft polymer formed on the substrate by covalently coupling the primary or secondary amines with a thermally labile radical initiator and subsequently contacting the substrate surface with a solution of one or more polymerizable monomers. Methods for the extracorporeal treatment of blood, blood plasma or blood serum employing the separating material, for affinity adsorption, ion-exchange adsorption, hydrophobic adsorption, or hydrophilic adsorption employing the separating material, and a separating column employing the separating material are also disclosed.Type: ApplicationFiled: February 16, 2012Publication date: June 28, 2012Applicant: GAMBRO LUNDIA ABInventors: Markus Storr, Egbert Müller, Wolfgang Freudemann
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Patent number: 8142844Abstract: The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.Type: GrantFiled: August 30, 2004Date of Patent: March 27, 2012Assignee: Gambro Lundia ABInventors: Markus Storr, Egbert Müller, Wolfgang Freudemann
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Patent number: 7968153Abstract: A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.Type: GrantFiled: July 4, 2005Date of Patent: June 28, 2011Assignees: Gambro Dialysatoren GmbH, Fraunhofer-Gesellschaft zur Forderung Det Angewandten ForschungInventors: Bernd Krause, Hermann Göhl, Christoph Beck, Jürgen Dannenmaier, Michael Müller, Edmund Kurz, Heinrich Malthaner, Christian Oehr, Markus Storr
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Patent number: 7875183Abstract: There is provided a method of reducing blood free light chain concentration in a subject, the method comprising the step of subjecting the subject's blood to haemodialysis, haemodiafiltration or haemofiltration. There is also provided the use of a dialysis membrane which is a membrane that allows passage of molecules having a molecular weight of up to 45 kDa in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa in the preparation of a haemodialysis unit for conducting haemodialysis, haemodiafiltration or haemofiltration on a subject to reduce blood free light chain concentration in the patient.Type: GrantFiled: November 15, 2006Date of Patent: January 25, 2011Assignees: Gambro Lundia AB, The Binding Site Group LimitedInventors: Arthur Randell Bradwell, Hermann Goehl, Markus Storr
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Publication number: 20100084339Abstract: The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.Type: ApplicationFiled: September 1, 2009Publication date: April 8, 2010Inventors: Colin Hutchison, Paul Cockwell, Hermann Göhl, Bernd Krause, Markus Storr
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Patent number: 7644825Abstract: The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.Type: GrantFiled: October 17, 2003Date of Patent: January 12, 2010Assignee: Gambro Lundia ABInventors: Bernd Krause, Matthias Wessling, Hermann Göhl, Markus Storr
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Patent number: 7591948Abstract: A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.Type: GrantFiled: April 23, 2003Date of Patent: September 22, 2009Assignees: Gambro Lundia AB, Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Michael Müller, Christian Oehr, Heinrich Malthaner, Hermann Goehl, Reinhold Deppisch, Markus Storr
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Publication number: 20090163599Abstract: The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.Type: ApplicationFiled: June 3, 2005Publication date: June 25, 2009Inventors: Markus Storr, Reinhold Deppisch, Werner Beck, Jürgen Bernhagen, Ina Merz, Georg Geiger
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Publication number: 20090057225Abstract: The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges.Type: ApplicationFiled: April 6, 2006Publication date: March 5, 2009Inventors: Bernd Krause, Markus Hornung, Thomas Ertl, Markus Storr
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Publication number: 20070296105Abstract: A continuous method for production of a porous hollow fibre membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a porous hollow fibre membrane produced by said method, an adsorption device containing such a porous hollow fibre membrane, and use of such a porous hollow fibre membrane.Type: ApplicationFiled: July 4, 2005Publication date: December 27, 2007Inventors: Bernd Krause, Hermann Gohl, Christoph Beck, Jurgen Dannenmaier, Michael Muller, Edmund Kurz, Heinrich Malthaner, Christian Oehr, Markus Storr