Abstract: The invention relates to a seal containing a substrate which can be applied to an object to be sealed, so that said seal is changed when it is removed without authorization, wherein the substrate contains or comprises a polymer and/or a glass and at least one optical waveguide is arranged in the substrate, at least one first Bragg grating being arranged in said optical waveguide, wherein the substrate has a thickness of less than 200 ?m. The invention further relates to a system having a seal of this kind and having an evaluation device, and also to a sealing method.

Abstract: The invention relates to a seal containing a substrate which can be applied to an object to be sealed, so that said seal is changed when it is removed without authorization, wherein the substrate contains or comprises a polymer and/or a glass and at least one optical waveguide is arranged in the substrate, at least one first Bragg grating being arranged in said optical waveguide, wherein the substrate has a thickness of less than 200 ?m. The invention further relates to a system having a seal of this kind and having an evaluation device, and also to a sealing method.

Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which do not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with ?2 microglobulin and peptide. These antibodies are useful in the diagnosis and treatment of HLA-B27 mediated conditions, particularly those associated with B272, the spondylarthritides, a group of related diseases including ankylosing spondylitis (AS) and reactive arthritis (ReA or Reiter's syndrome). The antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, anti-inflammatory drugs, NSAIDs and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies HD4, HD5 and HD6 whose sequences are provided herein.

Abstract: A method of gravimetric volume determination is described in which a load cell can be calibrated either outside of an analytic analyzer for gravimetric calibration of the analyzer, or in a fully automated manner inside the analyzer.

Abstract: A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the following components contained in housing (11): a load cell (12) for gravimetric volume determination, a weighing container (13) for receiving a liquid to be weighed with said load cell (12), a windbreak (14) which shields said weighing container (13) from air flow, an evaporation trap (15) which prevents evaporation of liquid loaded into said weighing container (13), a temperature sensor (21), an air-pressure sensor (31) and a humidity sensor (41) for sensing temperature, air pressure and humidity respectively at predetermined points within said housing (11), and an electronic processing unit for processing electrical output signals delivered by said load cell (12) and by said sensors (21, 31, 41).

Abstract: A method of gravimetric volume determination is described in which a load cell can be calibrated either outside of an analytic analyzer for gravimetric calibration of said analyzer, or in a fully automated manner inside said analyzer.

Abstract: A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the following components contained in housing (11): a load cell (12) for gravimetric volume determination, a weighing container (13) for receiving a liquid to be weighed with said load cell (12), a windbreak (14) which shields said weighing container (13) from air flow, an evaporation trap (15) which prevents evaporation of liquid loaded into said weighing container (13), a temperature sensor (21), an air-pressure sensor (31) and a humidity sensor (41) for sensing temperature, air pressure and humidity respectively at predetermined points within said housing (11), and an electronic processing unit for processing electrical output signals delivered by said load cell (12) and by said sensors (21, 31, 41).