Abstract: The present invention relates to compounds according to general formula (I) which act as inhibitors of NaV1.8 and can be used in the treatment of pain.

Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.

Abstract: A fork light barrier (1), provided with at least one first, one second, and one third light sensor (FT1 to FT3), which are arranged along an axis (X), wherein the second light sensor (FT2) lies between the first light sensor (FT1) and the third light sensor (FT3). The fork light barrier is advantageously incorporated into a position determining device and/or method.

Abstract: The invention relates to a device for handling and/or transporting back-up rolls and/or work rolls (4a, 4b) of a roll stand, preferably at least in pairs, especially in sets, between the roll stand arranged in a roll ball and a roll workshop, and in the roll workshop. Said device comprise a roll-changing pit that extends transversely to the roll direction of the roll stand, form the roll stand towards the roll workshop, and has displacement devices for at least one pair or set of dismantled back-up or work rolls (4a, 4b), and a roll-changing stand (8) that is arranged transversely to the roll-changing pit in the roll workshop and can be moved across said pit in or away from the roll direction of the roll stand. The aim of the invention is to enable the time required for a back-up roll change to be reduced and the back-up roll change to be simplified.

Abstract: The invention relates to a device for handling and/or transporting back-up rolls and/or work rolls (4a, 4b) of a roll stand, preferably at least in pairs, especially in sets, between the roll stand arranged in a roll ball and a roll workshop, and in the roll workshop. Said device comprise a roll-changing pit that extends transversely to the roll direction of the roll stand, form the roll stand towards the roll workshop, and has displacement devices for at least one pair or set of dismantled back-up or work rolls (4a, 4b), and a roll-changing stand (8) that is arranged transversely to the roll-changing pit in the roll workshop and can be moved across said pit in or away from the roll direction of the roll stand. The aim of the invention is to enable the time required for a back-up roll change to be reduced and the back-up roll change to be simplified.

Abstract: The invention relates to a roll stand (1) with a number of rollers (2, 3) and with an incoming guide (4) and/or an outgoing guide (5) which is/are fixed on the roll stand (1) before or after the rolling gap (6) in the rolling direction (W), respectively, and which is/are adjustably arranged in the direction perpendicular to the axis (7) of the rollers (2, 3) and perpendicular to the rolling direction (W), particularly in the vertical direction (V). To minimize damage in case of an accident, the invention provides for a predetermined breaking point (9) in the fixing means which fixes the incoming guide (4) and/or the outgoing guide (5) on the roll stand (1).

Abstract: The invention concerns a rolling stand (1) with backup rolls and/or work rolls (2, 3, 4, 5) for rolling plate (6) or strip, with at least one rest bar (8), which is arranged between the work roll chocks (7) and preferably is assigned to the upper roll (3); with an inlet/outlet guide (9) for a medium, e.g., cooling water or the like, arranged next to the rest bar (8); and with sealing means (10) for preventing the medium, e.g., cooling water, from dripping onto the rolling stock. In accordance with the invention, it is provided that the sealing means (10) for preventing the medium, e.g., cooling water, from dripping onto the rolling stock is designed as at least one sealing strip (11) arranged between the rest bar (8) and the inlet/outlet guide (9).

Abstract: The invention relates to a roll stand (1) with a number of rollers (2, 3) and with an incoming guide (4) and/or an outgoing guide (5) which is/are fixed on the roll stand (1) before or after the rolling gap (6) in the rolling direction (W), respectively, and which is/are adjustably arranged in the direction perpendicular to the axis (7) of the rollers (2, 3) and perpendicular to the rolling direction (W), particularly in the vertical direction (V). To minimize damage in case of an accident, the invention provides for a predetermined breaking point (9) in the fixing means which fixes the incoming guide (4) and/or the outgoing guide (5) on the roll stand (1).

Abstract: The invention concerns a rolling stand (1) with backup rolls and/or work rolls (2, 3, 4, 5) for rolling plate (6) or strip, with at least one rest bar (8), which is arranged between the work roll chocks (7) and preferably is assigned to the upper roll (3); with an inlet/outlet guide (9) for a medium, e.g., cooling water or the like, arranged next to the rest bar (8); and with sealing means (10) for preventing the medium, e.g., cooling water, from dripping onto the rolling stock. In accordance with the invention, it is provided that the sealing means (10) for preventing the medium, e.g., cooling water, from dripping onto the rolling stock is designed as at least one sealing strip (11) arranged between the rest bar (8) and the inlet/outlet guide (9).

Abstract: The invention provides for a method for predicting potential metabolites for a compound, comprising the steps of receiving a target compound from a user applying a set of optimized reaction rules to said target compound to generate a list of potential metabolites and calculating a probability score for each product compound on said list of potential metabolites. The reaction set is optimized by starting from a starting set of reaction rules and replacing at least one reaction rule for a reaction center in said starting set of reaction rules by one, or preferably two or more new rules, which are defined to apply to a reaction of said reaction center, but now specifying or differentiating based on the structural environments of said reaction center, if at least one of said new rules has a higher probability score than the replaced reaction rule when the starting set of reaction rules and the optimized set of reaction rules are both tested with a database of known metabolites of compounds.

Abstract: This invention provides a compound, or its possible salt, having the formula, wherein: Re and ?Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or —C(R4,R5)—, wherein R4 and R5 are independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2 and R3 are independently H, halogen, —CF3, —OCF3, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and wherein Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-

Abstract: A gasket includes at least one layer having a sealing surface that is at least partially coated with an elastomer base layer. A second, elastically deformable, sealing material is applied to the elastomer base layer and isolates at least one area of said sealing surface that is free of any media-conveying holes.

Abstract: This invention provides a compound, or its possible salt, having the formula, wherein: Re and ?Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or —C(R4,R5)—, wherein R4 and R5 are independently H, (1C-2C)alkyl or form together a spiro(3C-5C)cycloalkyl; R1 is H, halogen, CF3 , or (1C-4C)alkyl; R2 and R3 are independently H, halogen, —CF3, —OCF3, (1C-8C)alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and wherein Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, which alkyl, alkenyl and aryl can optionally be substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl or halo(1C-8C)alkyl; or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1