Abstract: An interspinous process spacer for implantation in an interspinous space between a superior spinous process and an inferior spinous process includes a balloon-like body, a first deployable protrusion and a second deployable protrusion. The body has a distal end, a proximal end and a longitudinal axis extending between the proximal and distal ends. The spacer is arrangeable in an unexpanded configuration and an expanded configuration. The first deployable protrusion is mounted proximate the proximal end and the second deployable protrusion is mounted proximate the distal end. The first and second deployable protrusions are oriented generally parallel to the longitudinal axis in the unexpanded configuration and generally perpendicular to the longitudinal axis in the expanded configuration.

Abstract: The invention relates to a cleaning system for a set of instruments associated or in contact with an image plate readout device, as well as to a readout device comprising the cleaning system. The cleaning system comprises a disinfecting element, which emits electromagnetic radiation and/or ultrasonic radiation capable of destroying disease carriers, and which is adapted to emit said radiation towards an image plate conveyor mechanism encompassed by the image plate readout device.

Abstract: A method of disinfecting a readout device having a reader unit that reads an imaging medium, the method comprising: identifying an absence of the imaging medium from the inside of the readout device; and emitting, from a disinfecting element, radiation capable of destroying disease carriers onto an the interior of the readout device when the imaging medium is absent from inside the readout device.

Abstract: Transportable modular coating systems include a first transportable coating module comprising at least one first removable wall, a second transportable coating module comprising at least one second removable wall, wherein the first and second transportable coating modules are joinable when the first and second removable walls are removed, and a plurality of coating components fixed within the first and second transportable coating modules that combine to create a coating operation. The transportable coating module further includes a transportable control module that comprises a control system that operably connects to the plurality of coating components to operably control the coating operation.

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.

Abstract: The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.

Abstract: The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.

Abstract: A continuous process for the preparation of propylene oxide, comprising (a) reacting propene, optionally admixed with propane, with hydrogen peroxide in a reaction apparatus in the presence of acetonitrile as solvent, obtaining a stream S0 containing propylene oxide, acetonitrile, water, at least one further component B, optionally propene and optionally propane, wherein the normal boiling point of the at least one component B is higher than the normal boiling point of acetonitrile and wherein the decadic logarithm of the octanol-water partition coefficient (log Kow) of the at least one component B is greater than zero; (b) separating propylene oxide from S0, obtaining a stream S1 containing acetonitrile, water and the at least one further component B; (c) dividing S1 into two streams S2 and S3; (d) subjecting S3 to a vapor-liquid fractionation in a fractionation unit, obtaining a vapor fraction stream S4 being depleted of the at least one component B; (e) recycling at least a portion of S4, optionally after

Abstract: A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, optionally propane, and at least one dissolved potassium salt of a phosphorus oxyacid wherein the molar ratio of potassium relative to phosphorus in the at least one potassium salt of a phosphorus oxyacid is in the range of from 0.6 to 1.

Abstract: The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties.

Abstract: A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile, water, dissolved potassium dihydrogen phosphate, and optionally propane; (ii) passing the liquid feed stream provided in (i) into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MWW, and subjecting the liquid feed stream to epoxidation reaction conditions; (iii) removing an effluent stream from the epoxidation reactor; wherein the concentration of the dissolved potassium dihydrogen phosphate in the liquid feed stream is at least 10% of the solubility limit of the potassium dihydrogen phosphate in the liquid feed stream.

Abstract: The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.

Abstract: The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilisate containing thermolysin and one or more salts, is contacted with an aqueous buffer with a low salt concentration and a first solution is formed. Subsequently, a further salt in solid form is added and dissociated, thereby forming a second solution comprising thermolysin in a stabilized form.

Abstract: A method for implementing a transition from a functioning steering assistance system to a deactivated steering assistance system when a fault occurs, comprising the following steps: establishing the fault of the steering assistance system; establishing that all high-side power switches are functional (first case), or establishing that all low-side power switches are functional (second case); and in the first case: opening all high-side power switches and performing PWM-like control of the low-side power switches; or in the second case: opening all low-side power switches and performing PWM-like control of the high-side power switches.

Abstract: The present invention relates to a lubricant composition for a process for reducing the paraffin content of mineral oil compositions, by providing a mineral oil composition with a dewaxing aid, cooling to form a paraffin precipitate and at least partly removing the paraffin precipitate formed. The dewaxing aid used is a copolymer mixture comprising at least three copolymers, the copolymers differing in the composition of the repeat units.

Abstract: Described is a method for operating a steering system (4) in a motor vehicle, said steering system (4) comprising an electric drive unit (15) for boosting the steering force. The electric drive unit (15) is operated using software. When the software is restarted, the drive unit (15) is operated in such a way that a torque introduced into the drive unit (15) is damped.

Abstract: A continuous process for the preparation of propylene oxide, comprising (a) reacting propene, optionally admixed with propane, with hydrogen peroxide in a reaction apparatus in the presence of acetonitrile as solvent, obtaining a stream S0 containing propylene oxide, acetonitrile, water, at least one further component B, optionally propene and optionally propane, wherein the normal boiling point of the at least one component B is higher than the normal boiling point of acetonitrile and wherein the decadic logarithm of the octanol-water partition coefficient (log Kow) of the at least one component B is greater than zero; (b) separating propylene oxide from S0, obtaining a stream S1 containing acetonitrile, water and the at least one further component B; (c) dividing S1 into two streams S2 and S3; (d) subjecting S3 to a vapor-liquid fractionation in a fractionation unit, obtaining a vapor fraction stream S4 being depleted of the at least one component B; (e) recycling at least a portion of S4, optionally after

Abstract: The invention relates to a carbon brush arrangement for connection to an electric motor, comprising at least one carbon brush (17, 18) connected to a connection means (29) provided with a plastic connection housing (32) via a connection conductor (15, 16) provided with a plastic sheath (24, 25), said plastic sheath (24, 25) consisting of perfluoroalkoxy polymer (PFA) in at least a region of transition (33, 34) to the connection housing (32).

Abstract: The present invention relates to a process for the regeneration of a catalyst comprising a titanium-containing zeolite, said catalyst having been used in a process for the preparation of an olefin oxide and having phosphate deposited thereon, said process for the regeneration comprising the steps: (a) separating the reaction mixture from the catalyst, (b) washing the catalyst obtained from (a) with liquid aqueous system; (c) optionally drying the catalyst obtained from (b) in a gas stream comprising an inert gas at a temperature of less than 300° C.; (d) calcining the catalyst obtained from (c) in a gas stream comprising oxygen at a temperature of at least 300° C.

Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.