Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

Abstract: The disclosure relates, inter alia, to a vehicle headlight (10), for example for a motor vehicle (1), wherein the vehicle headlight (10) comprises an illumination matrix (534) with a plurality of independently controllable illumination pixels for generating a (for example time-variant) illumination pattern, wherein the vehicle headlight (10) comprises an objective for imaging the illumination pattern, and wherein the objective comprises at least one objective lens.

Abstract: The disclosure relates, inter alia, to a motor vehicle (1) having a vehicle headlight (10) which comprises a lighting lens (46), the lighting lens (46) comprising a lens body (460) made of transparent material with at least one light entrance surface (462) and at least one light exit surface, wherein the lighting lens (46) further comprises a lighting assembly (461) which comprises a carrier (4612) on which is arranged a lighting matrix (4611) with a plurality of independently controllable lighting pixels, wherein by means of the lighting matrix (4611) light can be irradiated into the light entrance surface (462) of the lens body (460), which light exits from the light exit surface of the lens body (460), wherein between the lighting matrix (4611) and the light entrance surface (462) an air gap (464) is provided which is sealed dust-tight but not air-tight with respect to the surroundings of the lighting lens (46).

Abstract: The disclosure relates to a method for manufacturing an optical element, where a blank of glass is heated and/or provided and, after heating and/or after being provided between a first mold (UF) and at least one second mold (OF), is press molded, for example on both sides, to form the optical element and is then sprayed with a surface treatment agent.

Abstract: In a method for the computer-aided processing of a status change of an article carrier in a picking system, a storage and conveying region of the picking system, along with article carriers located thereupon, are virtualized in a computer. Pieces of status change information relating to a change in a physical status of an article carrier and/or relating to a change in a status of a control program for the article carrier are provided by an assigned digital twin of the article carrier and for digital twins of other article carriers. Further, a picking system carries out the method.

Abstract: The disclosure relates, inter alia, to a vehicle headlight (10), for example for a motor vehicle (1), wherein the vehicle headlight (10) comprises an illumination matrix (534) with a plurality of independently controllable illumination pixels for generating a (for example time-variant) illumination pattern, wherein the vehicle headlight (10) comprises an objective for imaging the illumination pattern, and wherein the objective comprises at least one objective lens.

Abstract: A heat pipe having a working chamber having an evaporator region operatively connected to a heat source, and a condenser region operatively connected to a heat sink. A working fluid is provided in the working chamber, and heat is transferred from the heat source to the heat sink by the working fluid in a first state of operation. The heat pipe is a switchable and/or programmable thermal diode or a switchable and/or programmable heat switch, at least one activatable functional material is provided, which is arranged and configured to keep the evaporator region free of the working fluid and/or to prevent the working fluid from evaporating in a second state of operation, in order to reduce and/or hinder heat transfer and/or to alter the preferential direction of heat conduction. A system and method for switching and/or programming heat transfer in a heat pipe are also provided.

Abstract: Methods, systems, and computer-readable storage media for selective use of Internet-of-Things (IoT) data in data analytics systems. Implementations include receiving IoT data from an IoT device, determining that hardening is to be applied to the IoT data, comparing a timestamp of the IoT data to a hardening value, and in response to comparing, selectively using the IoT data in one or more uses by the data analytics system.

Abstract: An example a circuit for controlling a power converter comprises a first power domain circuit including a first control circuit and a first driver circuit, wherein the first control circuit controls the first driver circuit to drive a first semiconductor device, wherein a second power domain circuit includes a second control circuit and a second driver circuit. The first control circuit is configured to receive a control signal for controlling the second driver circuit to drive a second semiconductor device; and identify, based on the control signal, a future electrical characteristic of a second power domain output of the power converter. Additionally, the first control circuit is configured to determine, based on the future electrical characteristic of the second power domain output of the power converter, whether to adjust one or more control parameters for controlling the first driver circuit to drive the first semiconductor device.

Abstract: The invention relates, inter alia, to a vehicle headlight having a lens arrangement, wherein the lens arrangement includes a first lens (input lens), a second lens (first middle lens), at least a third lens (second middle lens), and a front lens, wherein the second lens (first middle lens) is arranged in the light path between the first lens (input lens) and the front lens, and wherein the at least third lens (second middle lens) is arranged in the light path between the second lens (first middle lens) and the front lens.

Abstract: An example controller for a flyback power converter includes a secondary-side circuit comprising a secondary-side controller. The secondary-side controller is configured to sense an electrical characteristic of a secondary-side output of the flyback power converter, select, based on the sensed electrical characteristic, a power mode, and transmit, over a communication channel, a control message specifying the selected power mode. A primary-side circuit of the controller includes a primary-side controller. The primary-side controller is configured to receive, over the communication channel, the control message specifying the selected power mode and control primary-side flyback drive circuitry of the primary-side circuit to drive a primary-side output of the flyback power converter according to the selected power mode so as to control a value of the electrical characteristic of the secondary-side output of the flyback power converter.

Abstract: An example a circuit for controlling a power converter comprises a first power domain circuit including a first control circuit and a first driver circuit, wherein the first control circuit controls the first driver circuit to drive a first semiconductor device, wherein a second power domain circuit includes a second control circuit and a second driver circuit. The first control circuit is configured to receive a control signal for controlling the second driver circuit to drive a second semiconductor device; and identify, based on the control signal, a future electrical characteristic of a second power domain output of the power converter. Additionally, the first control circuit is configured to determine, based on the future electrical characteristic of the second power domain output of the power converter, whether to adjust one or more control parameters for controlling the first driver circuit to drive the first semiconductor device.

Abstract: A transport and manipulation system has an activity area in which a provisioning device is arranged which includes takeover and handover stations. The activity area includes a working area in which static workstations for manually executing processing orders are arranged, and a travel area, in which autonomous transport vehicles can move. Each transport vehicle is configured for automatically taking over a load carrier at the takeover station according to a transport order received, transporting it to a workstation and dispensing it there, or taking it over at the workstation, transporting it to the handover station and dispensing it there. The travel area includes first and second travel sections defining therein first and second travel speeds, respectively. The second travel speed is higher than the first travel speed. The second travel section is bounded against the first travel section, wherein transport vehicles can pass the boundary at a passing zone.

Abstract: The disclosure relates to a method for manufacturing an optical element, where a blank of glass is heated and/or provided and, after heating and/or after being provided between a first mold (UF) and at least one second mold (OF), is press molded, for example on both sides, to form the optical element and is then sprayed with a surface treatment agent.

Abstract: A computer-implemented method, a computer system and a computer program for controlling electric vehicle charging infrastructure that is used by a plurality of electric vehicles, wherein the infrastructure comprises a plurality of charging points. The method comprises receiving schedule information for the electric vehicles, the schedule information including, for each of the electric vehicles, at least one vehicle power characteristic. The method further comprises determining at least one power constraint for each of the electric vehicles based on the vehicle power characteristic. The method further comprises receiving an arrival indication for a respective one of the electric vehicles. The method further comprises assigning the respective electric vehicle to charge at one of the charging points for at least one time interval according to the respective power constraint.

Abstract: An example controller for a flyback power converter includes a secondary-side circuit comprising a secondary-side controller. The secondary-side controller is configured to sense an electrical characteristic of a secondary-side output of the flyback power converter, select, based on the sensed electrical characteristic, a power mode, and transmit, over a communication channel, a control message specifying the selected power mode. A primary-side circuit of the controller includes a primary-side controller. The primary-side controller is configured to receive, over the communication channel, the control message specifying the selected power mode and control primary-side flyback drive circuitry of the primary-side circuit to drive a primary-side output of the flyback power converter according to the selected power mode so as to control a value of the electrical characteristic of the secondary-side output of the flyback power converter.

Abstract: A vehicle body component comprising a lighting means arrangement, which is configured as a LED strip being at least bendable in the longitudinal direction thereof and comprises a plurality of LEDs arranged one after the other and electrically interconnected; and a base body configured to receive the lighting means arrangement at a light exit side. Further disclosed is a method for manufacturing a body component and a method for controlling a lighting means arrangement on a vehicle.

Abstract: A vehicle body component comprising a lighting means arrangement, which is configured as a LED strip being at least bendable in the longitudinal direction thereof and comprises a plurality of LEDs arranged one after the other and electrically interconnected; and a base body configured to receive the lighting means arrangement at a light exit side. Further disclosed is a method for manufacturing a body component and a method for controlling a lighting means arrangement on a vehicle.

Abstract: Methods, systems, and computer-readable storage media for selective segmentation of Internet-of-Things (IoT) data in data analytics systems. Implementations can include receiving IoT data from an IoT device, determining that segmentation is to be applied to the IoT data, determining a segment start and a segment end for a segment based on one of a property represented in the IoT data and a property value represented in the IoT data, and providing a table that records the segment independently of the IoT data.

Abstract: The invention relates to a method and a system intended for delivering items (4) in delivery containers (3) and in which, in a supply depot (1), the items are order picked, in accordance with orders placed, into delivery containers and then the delivery containers are loaded onto a transport rack (12). The transport rack is loaded with the delivery containers in a loading sequence determined by the computer system (2). Thereafter, the transport racks are transported, by means of a transport system, from the supply depot to a buffer depot (collection depot). A consignee (68) can collect the ordered item from the buffer depot at an issuing station (56). The transport rack is positioned, in the buffer depot, against a docking apparatus (54) such that a storage and retrieval unit (17) can access compartments in the transport rack.