Patents by Inventor Marla Sokolowski

Marla Sokolowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating neural anoxia and spreading depression
    Patent number: 8026217
    Abstract: Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 27, 2011
    Assignee: Florida Atlantic University
    Inventors: Ken Dawson-Scully, R. Meldrum Robertson, Gary A. B. Armstrong, Marla Sokolowski
  • Thermoprotective compositions of pkg pathway inhibitors and method of use thereof
    Patent number: 7858579
    Abstract: Neural thermoprotective compositions comprising a pharmacological inhibitor of the PKG pathway are described, as are methods of treating patients and providing neural thermoprotection with the same.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: December 28, 2010
    Inventors: Kenneth Dawson-Scully, Marla Sokolowski, Clement Kent, R. Meldrum Robertson, Gary A. Armstrong
  • COMPOSITIONS AND METHODS FOR TREATING NEURAL ANOXIA AND SPREADING DEPRESSION
    Publication number: 20090124558
    Abstract: Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines.
    Type: Application
    Filed: October 3, 2008
    Publication date: May 14, 2009
    Applicant: Florida Atlantic University
    Inventors: Ken Dawson-Scully, R. Meldrum Robertson, Gary A.B. Armstrong, Marla Sokolowski
  • Thermoprotective compositions of PKG pathway inhibitors and method of use thereof
    Publication number: 20070184044
    Abstract: Neural thermoprotective compositions comprising a pharmacological inhibitor of the PKG pathway are described, as are methods of treating patients and providing neural thermoprotection with the same.
    Type: Application
    Filed: October 4, 2006
    Publication date: August 9, 2007
    Inventors: Kenneth Dawson-Scully, Marla Sokolowski, Clement Kent, R. Meldrum Robertson, Gary Armstrong