Patents by Inventor Marlene F. Sisemore

Marlene F. Sisemore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of epoxide hydrolases for the treatment of inflammation
    Patent number: 8815951
    Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: August 26, 2014
    Assignee: The Regents of the University of California
    Inventors: Bruce D Hammock, Jiang Zheng, Christophe Morisseau, Kazuhiko Motoba, Mehran F. Moghaddam, Babak Borhan, David F. Grant, Jessica Greene, Marlene F. Sisemore, James Sanborn
  • Epoxide hydrolase inhibitor methods
    Patent number: 6174695
    Abstract: The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: January 16, 2001
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Mehran F. Moghaddam, Jeffrey M. Cheek, Babak Borhan, James Fergusson, David F. Grant, Jessica F. Greene, Kazuhiko Matoba, Jiang Zheng, Marlene F. Sisemore
  • Dihydroxy-oxy-eicosadienoates
    Patent number: 5955496
    Abstract: The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: September 21, 1999
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Mehran F. Moghaddam, Jeffrey M. Cheek, Babak Borhan, James Fergusson, David F. Grant, Jessica F. Greene, Kazuhiko Matoba, Jiang Zheng, Marlene F. Sisemore