Patents by Inventor Marlies HAGER

Marlies HAGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCASPASE-3 ACTIVATION AND IMMUNOTHERAPY FOR TREATMENT OF CANCER
    Publication number: 20220226311
    Abstract: The blood-brain barrier penetrant procaspase-3-activating drug, PAC-1, has been identified as an effective approach to inducing immune stimulatory destruction of cancer cells. PAC-1 induces cleavage of MLH1 in cancer cells, and studies show that inactivation of MLH1 leads to increased mutational burden and neoantigen presentation by major histocompatibility complex (MHC) products. Herein is described a mechanistic-based strategy to bring the power of immunotherapy in an effective fashion for treatment of cancer.
    Type: Application
    Filed: June 1, 2020
    Publication date: July 21, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Paul J. HERGENROTHER, Timothy M. FAN, Matthew BOUDREAU, William MONTGOMERY, Hyang-Yeon LEE, Marlies HAGER, Diana RANOA, Myung-ryul LEE