Patents by Inventor Marlis Zeiler

Marlis Zeiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative standard for mass spectrometry of proteins
    Patent number: 9063149
    Abstract: This invention relates to a method of determining the absolute amount of a target polypeptide in a sample using mass spectrometry.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: June 23, 2015
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., ATLAS ANTIBODIES AB
    Inventors: Matthias Mann, Marlis Zeiler, Mathias Uhlen, Emma Lundberg, Werner Lothar Straube
  • QUANTITATIVE STANDARD FOR MASS SPECTROMETRY OF PROTEINS
    Publication number: 20140072991
    Abstract: The present invention provides a method of determining the absolute amount of a target polypeptide in a sample, said method comprising the following steps: (a) adding (aa) a fusion polypeptide to said sample, said fusion polypeptide comprising (i) at least one tag sequence and (ii) a subsequence of the target polypeptide; and (ab) a known absolute amount of a tag polypeptide comprising or consisting of said tag sequence according to (aa) to said sample, wherein said fusion polypeptide on the one hand is mass-altered as compared to said target polypeptide and said tag polypeptide on the other hand, for example, said fusion polypeptide on the one hand and said target polypeptide and said tag polypeptide on the other hand are differently isotope labeled; (b) performing proteolytic digestion of the mixture obtained in step (a); (c) subjecting the result of proteolytic digestion of step (b), optionally after chromatography, to mass spectrometric analysis; and (d) determining the absolute amount of said target poly
    Type: Application
    Filed: April 4, 2012
    Publication date: March 13, 2014
    Applicants: ATLAS ANTIBODIES AB, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Matthias Mann, Marlis Zeiler, Mathias Uhlen, Emma Lundberg, Werner Straube