Patents by Inventor Marni J. FALK

Marni J. FALK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and Methods for Computing Measurements for Mitochondrial Diseases
    Publication number: 20210375467
    Abstract: This disclosure is directed to methods of methods of computing a composite measurement comprising employing two or more sub-instruments to measure one or more clinical symptoms of mitochondrial dysfunction or mitochondrial disease. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
    Type: Application
    Filed: June 26, 2019
    Publication date: December 2, 2021
    Applicants: RIBONOVA INC., The Children's Hospital of Philadelphia
    Inventors: Marni J. Falk, Nigel L. Webb, Shana E. McCormack, Eric C. Yuen, Zarazuela Zolkipli-Cunningham, Anthony W. Ford-Hutchinson
  • Methods of Treating Mitochondrial Dysfunction
    Publication number: 20210283072
    Abstract: This disclosure is directed to methods of treating or preventing mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of probucol, or a pharmaceutically acceptable salt thereof. This disclosure is also directed to methods of diagnosing genetic mitochondrial disease in a subject prior to and in association with said treatment or prevention. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.
    Type: Application
    Filed: June 26, 2019
    Publication date: September 16, 2021
    Applicant: RIBONOVA INC.
    Inventors: Marni J. Falk, Shana E. McCormack, Zaraxuela Zolkipli-Cunningham, Nigel L. Webb, Eric C. Yuen, Anthony W. Ford-Hutchinson
  • COMPOSITIONS AND METHODS FOR TREATMENT OF MITOCHONDRIAL RESPIRATORY CHAIN DYSFUNCTION AND OTHER MITOCHONDRIAL DISORDERS
    Publication number: 20210268008
    Abstract: Compositions and methods for treatment of mitochondrial respiratory chain dysfunction and other mitochondrial disorders are provided. Also disclosed are a number of screening assays having utility for the identification of agents which modulate the phenotype associated with mitochondrial respiratory chain dysfunction.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 2, 2021
    Inventors: Marni J. Falk, Eiko Nakamaru-Ogiso
  • MUSCLE NANOSENSOR FOR MINIMALLY-INVASIVE TISSUE MEASUREMENT OF MITOCHONDRIAL FUNCTIONS
    Publication number: 20210007637
    Abstract: The present disclosure provides methods, nanosensor devices, and uses for in vivo tissue measurement of mitochondrial physiology, including tissue oxygen and other readouts, such as in mitochondrial myopathy, disease, diagnosis, biomarker assessment, and monitoring of interventions and therapies.
    Type: Application
    Filed: March 12, 2019
    Publication date: January 14, 2021
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Zarazuela ZOLKIPLI-CUNNINGHAM, Marni J. FALK, Mark ALLEN
  • Mitochondrial Disease Genetic Diagnostics
    Publication number: 20200216903
    Abstract: Mitochondrial disease genetic diagnostics and methods of use thereof.
    Type: Application
    Filed: December 31, 2019
    Publication date: July 9, 2020
    Inventors: Marni J. Falk, Xiaowu Gai, Douglas C. Wallace, Hongbo Xie
  • Mitochondrial disease genetic diagnostics
    Patent number: 10519502
    Abstract: Mitochondrial disease genetic diagnostics and methods of use thereof are provided.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: December 31, 2019
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Marni J. Falk, Xiaowu Gai, Douglas C. Wallace, Hongbo Xie
  • Mitochondrial Disease Genetic Diagnostics
    Publication number: 20160258021
    Abstract: Mitochondrial disease genetic diagnostics and methods of use thereof are provided.
    Type: Application
    Filed: October 31, 2014
    Publication date: September 8, 2016
    Inventor: Marni J. FALK