Patents by Inventor Marnix Peferoen
Marnix Peferoen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242629Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: May 16, 2022Publication date: August 3, 2023Inventors: Peter Verheesen, Chris De Jonghe, Jan Geerinck, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Marnix Peferoen, Karin Thevissen, Bruno Cammue
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Publication number: 20210340556Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: December 7, 2020Publication date: November 4, 2021Inventors: Peter Verheesen, Jan Geerinck, João Filipe Veloso Vieira, Marnix Peferoen, Inge Elodie Van Daele
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Patent number: 10858666Abstract: This disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide encoding a polypeptide comprising a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. This disclosure further relates to a method for protecting at least part of a plant, plant tissue or plant cell from an infection with a plant pathogen, for inhibiting the growth of a plant pathogen on at least part of a plant, plant tissue or plant cell, or for increasing pathogen resistance of at least part of a plant, plant tissue or plant cell.Type: GrantFiled: November 5, 2015Date of Patent: December 8, 2020Assignee: BIOTALYSInventors: Peter Verheesen, Jan Geerinck, João Filipe Veloso Vieira, Marnix Peferoen, Inge Elodie Van Daele
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Publication number: 20180222966Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular, this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: March 20, 2018Publication date: August 9, 2018Inventors: Peter Verheesen, Chris De Jonghe, Jan Geerinck, Inge Elodie Van Daele, Miguel Francesco Coleta De Bolle, João Filipe Veloso Vieira, Marnix Peferoen, Karin Thevissen, Bruno Cammue
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Publication number: 20180179551Abstract: This disclosure relates to a transgenic plant or plant tissue. In particular this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus.Type: ApplicationFiled: November 5, 2015Publication date: June 28, 2018Applicant: AGROSAVFE N.V.Inventors: Peter Verheesen, Jan Geerinck, João Filipe Veloso Vieira, Marnix Peferoen, Inge Elodie Van Daele
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Patent number: 7888471Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinta nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: GrantFiled: March 14, 2008Date of Patent: February 15, 2011Assignee: Bayer Bioscience N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Publication number: 20090192290Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinta nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: ApplicationFiled: March 14, 2008Publication date: July 30, 2009Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Patent number: 7361751Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinta nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: GrantFiled: October 20, 2003Date of Patent: April 22, 2008Assignee: Bayer Bioscience N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Publication number: 20050097635Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinta nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: ApplicationFiled: October 20, 2003Publication date: May 5, 2005Applicant: BAYER BIOSCIENCE N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Audenhove, Marnix Peferoen
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Patent number: 6727409Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinta nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: GrantFiled: December 28, 1998Date of Patent: April 27, 2004Assignee: Bayer BioScience N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Patent number: 6448226Abstract: The present invention relates to transformed plants and plant cells comprising DNA molecules encoding Bacillus thuringiensis proteins with insecticidal activity. The invention relates more particularly to transformed plants and plant cells comprising DNA molecules encoding the protease resistant toxins BTS02618Aa or BTS02618Ab, as well as to methods of rendering plants or plant cells resistant to insects using these DNA molecules.Type: GrantFiled: December 23, 1999Date of Patent: September 10, 2002Assignee: Aventis CropScience N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen, Jeroen Van Rie, Roel Van Aarssen
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Patent number: 6143550Abstract: The present invention relates to transformed microrganisms comprising DNA molecules encoding Bacillus thuringiensis proteins with insecticidal activity. The invention relates more particularly to transformed microrganisms comprising DNA molecules encoding the protease resistant toxins BTS02618Aa or BTS02618Ab.Type: GrantFiled: February 6, 1998Date of Patent: November 7, 2000Assignee: Aventis CropScienceInventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen, Jeroen Van Rie, Roel Van Aarssen
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Patent number: 6028246Abstract: Four novel Bacillus thuringiensis strains, which are deposited at the BCCM-LMG under accession nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as spodoptera spp. and Agotis ipsilon, against Pyralidae such as Ostrinia nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains nd that encodes its respective toxin, is resistant to Lipidoptera. Each strain, itself, or its crystal, crystal protein, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combating Lepidoptera.Type: GrantFiled: May 31, 1995Date of Patent: February 22, 2000Assignee: Plant Genetic Systems, N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Patent number: 5885571Abstract: Four novel Bacillus thurungienisis strains which are deposited at the BCCM-LMG under accesion nos. LMG P-12592, LMG P-12593, LMG P-12594, and LMG P-13493, produce new crystal proteins during sporulation that are toxic to Lepidoptera, more particularly against Noctuidae such as Spodoptera spp. and Agrotis ipsilon, against Pyralidae such as Ostrinia nubilalis, and against Yponomeutidae such as Plutella xylostella, and that are encoded by a novel gene. The crystal proteins contain protoxins, which can yield a toxin as trypsin-digestion product. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that encodes its respective toxin, is resistant to Lepidoptera. Each strain, itself, or its crystals, crystals proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Lepidoptera.Type: GrantFiled: March 23, 1995Date of Patent: March 23, 1999Assignee: Plant Genetic Systems, N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen
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Patent number: 5861543Abstract: The present invention relates to transformed plants and plant cells comprising DNA molecules encoding Bacillus thuringiensis proteins with insecticidal activity. The invention relates more particularly to transformed plants and plant cells comprising DNA molecules encoding the protease resistant toxins BTS02618Aa or BTS02618Ab, as well as to methods of rendering plants or plant cells resistant to insects using these DNA molecules.Type: GrantFiled: December 6, 1995Date of Patent: January 19, 1999Assignee: Plant Genetic Systems N.V.Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen, Jeroen Van Rie, Roel Van Aarssen
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Patent number: 5837237Abstract: Two new Bacillus thuringiensis strains, which are deposited at the DSM under accession numbers 5870 and 5871, produce new crystal proteins during sporulation that are toxic to Coleoptera and that are encoded by new genes. The crystal proteins contain protoxins, which can yield toxins as trypsin-digestion products. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and encodes an insecticidally effective portion of its respective protoxin or encodes its respective toxin, is resistant to Coleoptera. Each strain, itself, or its crystals, crystal proteins, protoxin, toxin and/or insecticidally effective protoxin portion can be used as the active ingredient in an insecticidal composition for combatting Coleoptera.Type: GrantFiled: January 29, 1997Date of Patent: November 17, 1998Assignee: Plant Genetic Systems, N.V.Inventors: Marnix Peferoen, Bart Lambert, Katrien Van Audenhove
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Patent number: 5723756Abstract: Two new Bacillus thuringiensis strains, which are deposited at the DSM under accession numbers 5870 and 5871, produce new crystal proteins during sporulation that are toxic to Coleoptera and that are encoded by new genes. The crystal proteins contain protoxins, which can yield toxins as trypsin-digestion products. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and encodes an insecticidally effective portion of its respective protoxin or encodes its respective toxin, is resistant to Coleoptera. Each strain, itself, or its crystals, crystal proteins, protoxin, toxin and/or insecticidally effective protoxin portion can be used as the active ingredient in an insecticidal composition for combatting Coleoptera.Type: GrantFiled: May 18, 1995Date of Patent: March 3, 1998Assignee: Plant Genetic Systems, N.V.Inventors: Marnix Peferoen, Bart Lambert, Katrien Van Audenhove
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Patent number: 5683691Abstract: Two new Bacillus thuringiensis strains, which are deposited at the DSM under accession nos. 5131 and 5132, produce crystal proteins during sporulation that are toxic to Coleoptera. The crystal proteins contain 74 kDa and 129 kDa protoxins, respectively, which can yield 68 and 66 kDa toxins, respectively, as trypsin-digestion products. A plant, the genome of which is transformed with a DNA sequence that comes from either one of the strains and that codes for its respective toxin, is resistant to Coleoptera. Each strain, itself, or its crystals, crystal proteins, protoxin or toxin can be used as the active ingredient in an insecticidal composition for combatting Coleoptera.Type: GrantFiled: June 5, 1995Date of Patent: November 4, 1997Assignee: Plant Genetic Systems, N.V.Inventors: Marnix Peferoen, Bart Lambert, Henk Joos
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Patent number: 5659123Abstract: New modified Cry proteins, particularly modified CryIIIA proteins, having significantly altered toxicity, and DNA sequences encoding these proteins, are designed. Analysis of solvent-accessible amino acid positions in domain II of the CryIIIA protein by alanine-scanning mutagenesis identified individual amino acids involved in corn rootworm toxicity. Random replacement of these amino acids identifies modified proteins with improved toxicity. A combination of all or most thus identified improved amino acids in a single protein yields modified CryIIIA proteins with significantly improved toxicity. Particularly regions protruding from the Cry molecule and located at the apex of the Cry proteins, were identified as involved in toxicity.Type: GrantFiled: August 26, 1994Date of Patent: August 19, 1997Assignee: Plant Genetic Systems, N.V.Inventors: Jeroen Van Rie, Stefan Jansens, Marnix Peferoen
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Patent number: 5628995Abstract: A method to combat or control Ostrinia nubilalis by contacting such insects with a CryIB protein or a combination of a CryIB protein and a CryIAb or CryIAc protein.Type: GrantFiled: January 25, 1995Date of Patent: May 13, 1997Assignee: Plant Genetic Systems N.V.Inventors: Marnix Peferoen, Stefan Jansens, Peter Denolf