Patents by Inventor Marque D. Todd

Marque D. Todd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
    Publication number: 20030219714
    Abstract: This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes linked to native eukaryotic stress promoters, especially those of mammals. The kits and methods of this invention utilize at least one stress promoter from each of the following groups: redox stress, DNA stress, protein stress and energy/ionic stress. The invention also provides methods and diagnostic kits for identifying and characterizing compounds that are toxic to specific organs, such as skin and the eye, as well as for each of the individual stresses indicated above. The methods and diagnostic kits of this invention yield information concerning the action of a compound on a subcellular level. This information may be utilized to design antitoxins to compounds found to be toxic and in active drug design.
    Type: Application
    Filed: November 19, 2002
    Publication date: November 27, 2003
    Applicant: President and Fellows of Harvard College and Xenometrix, Inc.
    Inventors: Spencer B. Farr, Marque D. Todd
  • Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
    Publication number: 20030027127
    Abstract: This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels fr4om genes linked to native eukaryotic stress promoters, especially those of mammals. The kits and methods of this invention utilize at least one stress promoter from each of the following groups: redox stress; DNA stress; protein stress and energy/ionic stress. The invention also provides methods and diagnostic kits for identifying and characterizing compounds that are toxic to specific organs, such as skin and the eye, as well as for each of the individual stresses indicated above. The methods and diagnostic kits of this invention yield information concerning the action of a compound on a subcellular level. This information may be utilized to design antitoxins to compounds found to be toxic and in active drug design.
    Type: Application
    Filed: September 10, 2001
    Publication date: February 6, 2003
    Applicant: President and Fellows of Harvard College and Xenometrix, Inc.
    Inventors: Spencer B. Farr, Marque D. Todd
  • Methods and kits for eukaryotic gene profiling
    Patent number: 5811231
    Abstract: This invention provides methods and diagnostic kits for identifying and characterizing toxic compounds. These methods and diagnostic kits measure transcription or translation levels from genes linked to native eukaryotic stress promoters, especially those of mammals. The kits and methods of this invention utilize at least one stress promoter from each of the following groups: redox stress, DNA stress, protein stress and energy/ionic stress. The invention also provides methods and diagnostic kits for identifying and characterizing compounds that are toxic to specific organs, such as skin and the eye, as well as for each of the individual stresses indicated above. The methods and diagnostic kits of this invention yield information concerning the action of a compound on a subcellular level. This information may be utilized to design antitoxins to compounds found to be toxic and in active drug design.
    Type: Grant
    Filed: July 21, 1995
    Date of Patent: September 22, 1998
    Assignees: Pres. and Fellows of Harvard College, Xenometrix, Inc.
    Inventors: Spencer B. Farr, Marque D. Todd