Patents by Inventor Marsha Frazier

Marsha Frazier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
    Publication number: 20060019280
    Abstract: The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T?C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment.
    Type: Application
    Filed: June 9, 2005
    Publication date: January 26, 2006
    Inventors: Lei Chen, Marsha Frazier