Patents by Inventor Marsha L. Frazier

Marsha L. Frazier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutations in Kit Confer Imatinib Resistance in Gastrointestinal Stromal Tumors
    Publication number: 20080213774
    Abstract: The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T?C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment.
    Type: Application
    Filed: December 17, 2007
    Publication date: September 4, 2008
    Applicant: Board of Regents, The University of Texas System
    Inventors: Lei L. Chen, Marsha L. Frazier
  • Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors
    Patent number: 7329495
    Abstract: The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T?C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: February 12, 2008
    Assignee: Board of Regents, the University of Texas System
    Inventors: Lei L. Chen, Marsha L. Frazier
  • Metalocarboxypeptidase inhibitors and derived molecules used as antitumor agents
    Patent number: 6379959
    Abstract: The present invention relates to metalocarboxypeptidase inhibitors and to their natural protein variants or protein variants redesigned by engineering, as well as to peptidomimetic molecules derived from the above and used as antitumor agents.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: April 30, 2002
    Assignees: Universitat Autonoma de Barcelona, Universitat de Girona
    Inventors: Rafael De Llorens Duran, Carmen Blanco Aparicio, Miguel Angel Molina Vila, Esther Fernandez Salas, Enrique Querol Murillo, Francesc X. Aviles Puigvert, Marsha L. Frazier