Patents by Inventor Marsha Luna

Marsha Luna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for stabilizing 5-azacytidine in plasma
    Patent number: 7192781
    Abstract: The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at least about 3 hours at about room temperature, and for at least about 4 days at about ?70° C. If the acetonitrile is removed and evaporated to dryness, the 5-azacytidine in the resulting residue is stable for at least about 14 months at about ?70° C. The invention also provides methods for determining the 5-azacytidine in acetonitrile, or in the acetonitrile residue, using, for example, high-performance liquid chromatography. The methods of the invention permit a significant time interval between the initial processing of the whole blood sample and the time of 5-azacytidine determination.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: March 20, 2007
    Assignee: Pharmion Corporation
    Inventors: Marsha Luna, Larry Eden, Steven Burmaster
  • Methods for stabilizing 5-azacytidine in plasma
    Publication number: 20050227367
    Abstract: The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at least about 3 hours at about room temperature, and for at least about 4 days at about ?70° C. If the acetonitrile is removed and evaporated to dryness, the 5-azacytidine in the resulting residue is stable for at least about 14 months at about ?70° C. The invention also provides methods for determining the 5-azacytidine in acetonitrile, or in the acetonitrile residue, using, for example, high-performance liquid chromatography. The methods of the invention permit a significant time interval between the initial processing of the whole blood sample and the time of 5-azacytidine determination.
    Type: Application
    Filed: April 13, 2004
    Publication date: October 13, 2005
    Inventors: Marsha Luna, Larry Eden, Steven Burmaster