Abstract: Methods of enhancing the bioavailability of resveratrol, and for the treatment of at least one neuroinflammatory disorder in a subject, include orally administering to the subject a resveratrol solubulization product formulation consisting of: resveratrol; an emulsifying agent mixture of polysorbate 80 and polysorbate 20; at least one medium-chain triglyceride (MCT); and tocopherol or mixed tocopherols, or an oral pharmaceutical composition containing same. In the methods, the formulation is orally administered to the human subject under fasting conditions. Upon oral administration to a human subject under fasting conditions, the resveratrol solubulization product formulation or oral pharmaceutical composition containing same provides at least one of the following pharmacokinetic parameters: a. AUC(0-t) of at least about 500 h*ng/mL; b. AUC(0-infin.) of no more than about 2100 h*ng/mL; and c. Cmax of at least about 220 ng/ml, wherein t is between about 1 and about 24 hours.

Abstract: A solubilisation product consists of resveratrol, polysorbate 80 and polysorbate 20, at least one medium-chain triglyceride, and tocopherol. The solubilisation product is for use as a pharmaceutical product. The solubilisation product can be used as a pharmaceutical product in the treatment of Alzheimer's disease, Friedreich's ataxia, lysosomal diseases, in particular Tay-Sachs disease, cancer, diabetes, atherosclerosis, heart diseases, arthritis or autoimmune diseases.

Abstract: A solubilisation product consists of resveratrol, polysorbate 80 and polysorbate 20, at least one medium-chain triglyceride, and tocopherol. The solubilisation product is for use as a pharmaceutical product. The solubilisation product can be used as a pharmaceutical product in the treatment of Alzheimer's disease, Friedreich's ataxia, lysosomal diseases, in particular Tay-Sachs disease, cancer, diabetes, atherosclerosis, heart diseases, arthritis or autoimmune diseases.

Abstract: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

Abstract: A stable effervescent tablet granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising: an effective amount of a antidiabetic drug, an effervescing organic acid component, an effervescing base component; buffers, to modulate gastric ?ïí after ingestion, essentially free of solium; wherein said composition is completely solubilised within 5 minutes without stirring in 3 to 8 fluid ounces of water at between 5-20° C.

Abstract: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

Abstract: A composition and method for the treatment of dry mouth (xerostomia), comprising a sialogogic compound in combination with an effervescent organic acid-based buffering system.

Abstract: A pharmaceutical granular composition and method for taste masking bitter, or unpleasant tasting drugs comprising a drug core of a nonsteriodal anti-inflammatory drug, and as a taste masking agents, methacrylate ester copolymers. The method comprises coating the drug cores with separate layers of aqueous dispersions of the copolymers. Additionally, the coating composition may contain plasticizers and conventional excipients. The granules of the present invention can be used in the preparation of chewable tablets which have good palatability and bioavailability. Preferable copolymers are poly(ethylacrylate, methylmethacrylate) to which quaternary ammonium groups have been introduced to modify the permeability of the ester. The coating system of this invention releases the drug by diffusion and is influenced by drug solubility and media pH.

Abstract: This invention relates to a polymer-based cleanser for superficial and deep cleansing of skin.

Abstract: This invention is a long acting moisturizer particularly suited for moisturizing the epithelia.

Abstract: A pharmaceutical granular composition and method are provided for masking the taste of unpleasant tasting drugs, wherein drug cores are coated with separate layers of aqueous dispersions of methacrylate ester copolymers, preferably, poly(ethylacrylate, methyl methacrylate) to which quaternary ammonium groups have been introduced to modify the permeability of the ester. Additionally, the coating composition may contain plasticizers and conventional excipients. The coating system releases drug by diffusion and is influenced by drug solubility and media pH. The coated pharmaceutical granules of the invention can be used to prepare chewable tablets with good palatability and bioavailability.

Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.

Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.

Abstract: A method for modifying the balance between bone production and bone resorption in a host animal by administration of (-)-N-[[(5-chloro-benzothiazolyl)-thio]phenylacetyl]-L-cysteine to inhibit bone loss.

Abstract: A method for modifying the balance between bone production and bone resorption in a host animal by administration of etodolac to inhibit bone resorption.