Patents by Inventor Marshall D. Crew

Marshall D. Crew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immediate release dosage forms containing solid drug dispersions
    Patent number: 9211261
    Abstract: High loading immediate release dosage forms containing at least 30 wt % of a solid drug dispersion, at least 5 wt % of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 15, 2015
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, John E. Byers, Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Stephen J. Schadtle
  • Solid dispersion formulations and methods of use thereof
    Patent number: 8591944
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: November 26, 2013
    Assignee: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20130231350
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: April 1, 2013
    Publication date: September 5, 2013
    Applicant: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Patent number: 8491933
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: July 23, 2013
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Solid dispersion formulations and methods of use thereof
    Patent number: 8409560
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: April 2, 2013
    Assignee: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8389011
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: March 5, 2013
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20130035345
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: March 7, 2012
    Publication date: February 7, 2013
    Applicant: Zalicus Pharmaceuticals Ltd.
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • PHARMACEUTICAL COMPOSITIONS OF SEMI-ORDERED DRUGS AND POLYMERS
    Publication number: 20120322805
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 20, 2012
    Applicant: BEND RESEARCH, INC.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
    Publication number: 20120277315
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Application
    Filed: June 12, 2012
    Publication date: November 1, 2012
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Dougles A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
    Publication number: 20120252819
    Abstract: The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
    Type: Application
    Filed: June 12, 2012
    Publication date: October 4, 2012
    Inventors: Mahesh V. Padval, Jeff T. Gautschi, Daniel T. Smithey, Marshall D. Crew, Abizer Harianawala
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Patent number: 8257739
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8197848
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 12, 2012
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Method of making pharmaceutical multiparticulates
    Patent number: 7951403
    Abstract: A process for forming drug multiparticulates having improved drug crystallinity is disclosed, comprising modifying a conventional melt-congeal process by adding a volatile cospecies either to the molten mixture or to the process atmosphere, or to both.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 31, 2011
    Assignee: Pfizer Inc.
    Inventors: Dwayne T. Friesen, Marshall D. Crew, Roderick J. Ray, Leah E. Appel
  • Multiparticulate crystalline drug compositions having controlled release profiles
    Patent number: 7887844
    Abstract: A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: February 15, 2011
    Assignee: Pfizer Inc.
    Inventors: Leah E. Appel, Roderick J. Ray, David K. Lyon, James B. West, Scott B. McCray, Marshall D. Crew, Dwayne T. Friesen, Scott M. Herbig, Julian B. Lo
  • Multiparticulate compositions with improved stability
    Patent number: 7736672
    Abstract: A process is described for producing drug-containing multiparticulates with improved stability, characterized by an improvement in one or more of chemical stability, physical stability, or dissolution stability.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: June 15, 2010
    Assignee: Pfizer, Inc.
    Inventors: Roderick J. Ray, Leah E. Appel, Dwayne Thomas Friesen, Marshall D. Crew, Joshua R. Shockey
  • Extrusion process for forming chemically stable drug multiparticulates
    Patent number: 7625507
    Abstract: Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: December 1, 2009
    Assignee: Pfizer Inc.
    Inventors: Roderick J. Ray, Leah E. Appel, David D. Newbold, Dwayne T. Friesen, Scott B. McCray, David K. Lyon, James B. West, Marshall D. Crew, Joshua R. Shockey
  • IMMEDIATE RELEASE DOSAGE FORMS CONTAINING SOLID DRUG DISBURSIONS
    Publication number: 20080317851
    Abstract: High loading immediate release dosage forms containing at least 30 wt % of a solid drug dispersion, at least 5 wt % of a disintegrant and a porosigen are disclosed that exhibit excellent strength and aqueous solubility.
    Type: Application
    Filed: October 30, 2007
    Publication date: December 25, 2008
    Inventors: Leah E. Appel, John E. Byers, Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Stephen J. Schadtle
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 7235259
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: June 26, 2007
    Assignee: Pfizer Inc
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions of a sparingly soluble glycogen phosphorylase inhibitor
    Patent number: 7235260
    Abstract: Pharmaceutical compositions of a particularly effective sparingly soluble glycogen phosphorylase inhibitor are disclosed, as well as methods of making such compositions and dosage forms from such compositions.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: June 26, 2007
    Assignee: Pfizer Inc
    Inventors: Marshall D. Crew, Dwayne T. Friesen, Bruno C. Hancock, Chris Macri, James A. S. Nightingale, Ravi M. Shankar
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Publication number: 20040156905
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Application
    Filed: August 5, 2003
    Publication date: August 12, 2004
    Applicant: Pfizer Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey