Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a synthesis adapter base to receive a commercially available synthesis plate. A keeper is used to apply pressure to the commercially available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the system adapter base. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a synthesis adapter base to receive a commercially available synthesis plate. A keeper is used to apply pressure to the commercially available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the system adapter base. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.

Abstract: An improved apparatus for oligonucleotide synthesis that reduces reagent consumption and increase yield, typically comprising one or more synthesis vessels, each having a waste emitting end, a drain block located below and operably coupled to the synthesis vessel(s), a sealing device disposed between the synthesis vessel(s) and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating an exterior of the drain block and the waste collection reservoir(s), one or more waste tubes leading from the waste collection reservoir(s), each waste tube comprising a waste valve. In some embodiments the sealing device may comprise one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. In some embodiments, each equilibration hole may be operably coupled to a solenoid or flow control valve.

Abstract: An improved apparatus for oligonucleotide synthesis, that has four or more synthesis vessels, each synthesis vessel having a waste emitting end, a synthesis plate holding the four or more synthesis vessels, a drain block located below and coupled to the synthesis plate, a sealing device in contact with the synthesis plate and the drain block, one or more waste collection reservoirs located inside of the drain block, one or more equilibration holes, each equilibration hole penetrating the exterior of the drain block and the waste collection reservoir(s), one or more waste tubes connected to the waste collection reservoir(s), each waste tube comprising a waste valve. The sealing device may have one or more sealing blocks, and the equilibration holes may be located in the sealing blocks in lieu of in the drain block. Each equilibration hole may be coupled to a solenoid or flow control valve.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.

Abstract: Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.