Patents by Inventor Marshall L. Stoller
Marshall L. Stoller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11844724Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.Type: GrantFiled: October 25, 2021Date of Patent: December 19, 2023Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans AffairsInventors: Robert H. Grubbs, Marshall L Stoller, Ying Han, Frank L. Brodie
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Publication number: 20230285561Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: ApplicationFiled: March 22, 2023Publication date: September 14, 2023Inventors: Robert H. GRUBBS, Marshall L. STOLLER, Hoyong CHUNG, Alissa M. FITZGERALD, Thomas W. KENNY, Renee M. THOMAS
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Patent number: 11642410Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: GrantFiled: December 7, 2021Date of Patent: May 9, 2023Assignees: California Institute of Technology, The Regents of the University of CaliforniaInventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Publication number: 20220088198Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: ApplicationFiled: December 7, 2021Publication date: March 24, 2022Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Publication number: 20220087897Abstract: The disclosure pertains to methods and devices for administering a vibration expulsion therapy (VET) to a subject to expulse a urinary stone. The method comprises circumferentially administering vibrations to a subject's torso to facilitate movement of a urinary stone through the urinary system or to alleviate pain associated with a urinary stone. In certain embodiments, the method comprises circumferentially administering vibrations to a subject via a vest configured to envelope and tightly fit contours on the subject's torso, particular, the subject's lower torso and cover the subject's kidneys, ureter, and/or urinary bladder. Further provided is a system comprising a processor and a computer-readable medium comprising instructions that, when executed by the processor, causes the processor to actuate a vest placed on the subject's torso to circumferentially administer vibrations to the subject's torso or a portion thereof.Type: ApplicationFiled: August 27, 2021Publication date: March 24, 2022Inventors: Marshall L. Stoller, Avi Baskin, David Bayne, Ralph Wang
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Publication number: 20220040000Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.Type: ApplicationFiled: October 25, 2021Publication date: February 10, 2022Applicants: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans AffairsInventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
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Patent number: 11166846Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.Type: GrantFiled: January 3, 2020Date of Patent: November 9, 2021Assignees: California Institute of Technology, The Regents of the University of California, United States Government represented by the Department of Veterans AffairsInventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
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Publication number: 20200214890Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.Type: ApplicationFiled: January 3, 2020Publication date: July 9, 2020Inventors: Robert H. Grubbs, Marshall L. Stoller, Ying Han, Frank L. Brodie
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Patent number: 10357565Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: GrantFiled: October 8, 2018Date of Patent: July 23, 2019Assignees: California Institute of Technology, The Regents of the University of CaliforniaInventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Patent number: 10258645Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: GrantFiled: February 15, 2018Date of Patent: April 16, 2019Assignees: New York University, General Hospital Corporation, The Regents of the University of CaliforniaInventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller
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Publication number: 20190038749Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: ApplicationFiled: October 8, 2018Publication date: February 7, 2019Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Patent number: 10149906Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: GrantFiled: June 30, 2016Date of Patent: December 11, 2018Assignees: California Institute of Technology, The Regents of the University of CaliforniaInventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Patent number: 10052305Abstract: In various embodiments methods and composition are provided for the treatment and/or prophylaxis of cystinuria. In certain embodiments the methods involve administering to a mammal in need thereof (e.g., identified as at risk for, or having cystinuria) an effective amount of lipoic acid and/or one or more lipoic acid derivatives.Type: GrantFiled: October 3, 2016Date of Patent: August 21, 2018Assignee: BUCK INSTITUTE FOR RESEARCH ON AGINGInventors: Tiffany Zee, Marshall L. Stoller, Pankaj Kapahi
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Publication number: 20180169144Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: ApplicationFiled: February 15, 2018Publication date: June 21, 2018Inventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller
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Patent number: 9895396Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: GrantFiled: August 21, 2017Date of Patent: February 20, 2018Assignees: New York University, General Hospital Corporation, The Regents of the University of CaliforniaInventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller
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Publication number: 20170340664Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: ApplicationFiled: August 21, 2017Publication date: November 30, 2017Inventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller
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Patent number: 9737564Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: GrantFiled: March 7, 2016Date of Patent: August 22, 2017Assignees: New York University, General Hospital Corporation, The Regents of the University of CaliforniaInventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller
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Publication number: 20170112804Abstract: In various embodiments methods and composition are provided for the treatment and/or prophylaxis of cystinuria. In certain embodiments the methods involve administering to a mammal in need thereof (e.g., identified as at risk for, or having cystinuria) an effective amount of lipoic acid and/or one or more lipoic acid derivatives.Type: ApplicationFiled: October 3, 2016Publication date: April 27, 2017Inventors: TIFFANY ZEE, MARSHALL L. STOLLER, PANKAJ KAPAHI
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Publication number: 20160367669Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.Type: ApplicationFiled: June 30, 2016Publication date: December 22, 2016Inventors: Robert H. Grubbs, Marshall L. Stoller, Hoyong Chung, Alissa M. Fitzgerald, Thomas W. Kenny, Renee M. Thomas
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Publication number: 20160184349Abstract: Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.Type: ApplicationFiled: March 7, 2016Publication date: June 30, 2016Inventors: David S. Goldfarb, Brian Eisner, John Asplin, Marshall L. Stoller