Patents by Inventor Marshall L. Summar

Marshall L. Summar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220304966
    Abstract: A method for administration of citrulline for the treatment of sickle cell disease and other complications of sickle cell disease thereof.
    Type: Application
    Filed: June 3, 2022
    Publication date: September 29, 2022
    Inventors: Marshall L. SUMMAR, Frederick W. BARR, Suvankar MAJUMDAR
  • Patent number: 11351135
    Abstract: A method for administration of citrulline for the treatment of sickle cell disease and other complications of sickle cell disease thereof.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 7, 2022
    Assignees: VANDERBILT UNIVERSITY, THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER
    Inventors: Marshall L. Summar, Frederick W. Barr, Suvankar Majumdar
  • Patent number: 10525026
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 7, 2020
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick E. Barr
  • Patent number: 10500181
    Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: December 10, 2019
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick E. Barr, Reid Carleton Thompson
  • Patent number: 10265286
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis to reduce the uncoupling of eNOS enzyme dimer that leads to cardiopulmonary bypass-induced pulmonary injury.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: April 23, 2019
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick W. Barr
  • Publication number: 20180360787
    Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.
    Type: Application
    Filed: April 17, 2018
    Publication date: December 20, 2018
    Inventors: Marshall L. SUMMAR, Frederick E. BARR, Reid Carleton THOMPSON
  • Publication number: 20180289647
    Abstract: A method for administration of citrulline for the treatment of sickle cell disease and other complications of sickle cell disease thereof.
    Type: Application
    Filed: February 27, 2018
    Publication date: October 11, 2018
    Inventors: Marshall L. SUMMAR, Frederick W. BARR, Suvankar MAJUMDAR
  • Publication number: 20180214403
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis to reduce the uncoupling of eNOS enzyme dimer that leads to cardiopulmonary bypass-induced pulmonary injury.
    Type: Application
    Filed: December 22, 2017
    Publication date: August 2, 2018
    Inventors: Marshall L. SUMMAR, Frederick W. BARR
  • Patent number: 9943494
    Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: April 17, 2018
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick E. Barr, Reid Carleton Thompson
  • Publication number: 20170119715
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 4, 2017
    Inventors: Marshall L. SUMMAR, Brian W. Christman, Frederick E. Barr
  • Publication number: 20160374972
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis.
    Type: Application
    Filed: June 29, 2016
    Publication date: December 29, 2016
    Inventors: Marshall L. SUMMAR, Frederick E. BARR
  • Patent number: 9486429
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: November 8, 2016
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Brian W. Christman, Frederick E. Barr
  • Publication number: 20160317484
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Application
    Filed: June 10, 2016
    Publication date: November 3, 2016
    Inventors: Marshall L. Summar, Brian W. CHRISTMAN, Frederick E. BARR
  • Patent number: 8536225
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 17, 2013
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Brian W. Christman, Frederick E. Barr
  • Publication number: 20120252895
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Application
    Filed: April 25, 2012
    Publication date: October 4, 2012
    Inventors: Marshall L. Summar, Brian W. Christman, Frederick E. Barr
  • Patent number: 8188147
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: May 29, 2012
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Brian W. Christman, Frederick E. Barr
  • Publication number: 20120088835
    Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.
    Type: Application
    Filed: December 20, 2011
    Publication date: April 12, 2012
    Inventors: Marshall L. Summar, Frederick E. Barr, Reid Carleton Thompson
  • Publication number: 20090312423
    Abstract: Methods and compositions for treating lung conditions such as bronchopulmonary dysplasia or hypoxia-induced pulmonary hypertension in a subject, including administering to the subject an effective amount of a nitric oxide precursor such as citrulline.
    Type: Application
    Filed: February 2, 2009
    Publication date: December 17, 2009
    Inventors: Marshall L. Summar, Frederick E. Barr, Candice D. Fike, Judy L. Aschner
  • Publication number: 20090197964
    Abstract: Methods and compositions for treating a complication associated with aneurysmal subarachnoid hemorrhage (SAH), the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof. Methods and compositions for treating vasospasm, the method comprising administering an effective amount of a nitric oxide precursor to a subject in need thereof.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 6, 2009
    Inventors: MARSHALL L. SUMMAR, FREDERICK E. BARR, REID CARLETON THOMPSON
  • Publication number: 20080234379
    Abstract: Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from mRNA, it is possible to type a human carbamyl phosphate synthetase I with regard to the human carbamyl phosphate synthetase I polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (HVOD) associated with bone marrow transplants.
    Type: Application
    Filed: May 16, 2008
    Publication date: September 25, 2008
    Inventors: Marshall L. Summar, Brian W. Christman, Frederick E. Barr