Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Abstract: There is provided a syringe assembly comprising a first, self contained cylindrical storage means (211) containing a first substance (212) and a second, self contained, cylindrical storage means (213) containing a second substance (214). The second storage means is slidably received by the first storage means and is adapted to pierce a slidable sealing element of the first storage means for mixing of the first and second substances in the first storage means. Axially driving the sealing element of the first storage means effects ejection of the resulting mixed substance from the syringe for delivery to a patient. There is also disclosed a syringe assembly with a safety sheath for covering a needle of the syringe when in an extended position and which is slidable from the extended position to a retracted position to expose the needle for use.

Abstract: A method of widening a penis wherein a dermal fat graft including a block of fat and attached dermis is excised from the patient, the penis is degloved, the dermal fat graft is sutured to the exposed Bucks fascia and then reducing the penile skin; the method further including the step of following a post-operative treatment regime.

Abstract: A system for suspension of a serviette or table napkin (30) below the chin of a user; said system comprising a spring clip (14) and a suspension device (12); said suspension device adapted for placement about the neck (32) of a wearer; said clip adapted for depending from said suspension device.

Abstract: A remote control transmitter configured to operate with a vehicle controller. The transmitter is operable in an active mode and a passive mode and/or in the alternative embodiment the transmitter is operable as a one-way or a two-way transmitter. The transmitter is configured to switch from one mode, such as the passive or two-way mode, to the other mode, such as active or one-way mode, in response to at least one of a user activated signal or a battery threshold signal.

Abstract: The disclosed device is an additional, normally-closed relay positioned in line with the ignition switch and the functionality controlled by the OEM, normally-open relay. When the aftermarket system is in the disarmed state, the normally-closed relay is dormant in its closed position, thereby allowing the circuit to complete its intended loop. When the aftermarket security system is enabled, the normally-closed relay will open the current flow and prevent the current from reaching its target, thereby disrupting or disabling the operation of the vehicle function. If the normally-closed relay fails, it fails in its closed position, thereby not affecting the OEM system.

Abstract: A truss bracket for connecting a roof to a shipping container includes an initially flat rectangular sheet of material in which is formed a longitudinally extending fold line that divides the sheet of material into a first part and a second part that are disposed at a predetermined angle relative to one another when a fold is formed in the fold line. The first part is adapted to be secured to a vertical wall of a shipping container and the second part is adapted to be engaged to a roof. A plurality of flanges are stamped from the second part and are folded out at a ninety degree angle relative to the plane of the second part to enable connection of the second part to the roof. A house is made by joining plural shipping containers together and securing a roof to the shipping container by using the truss bracket.

Abstract: A method of penis lengthening including dividing the suspensory ligament down to the inferior public arch, dividing the fundiform ligaments; or dividing the first and second corpus cavernosum circumferentially. A method of widening a penis where a dermal fat graft is sutured to the exposed Bucks fascia. Post operative drug and exercise to maintain the outcome of penis lengthening or widening.

Abstract: A remote control transmitter configured to operate with a vehicle controller. The transmitter is operable in an active mode and a passive mode. In the active mode the disarm/unlock command is sent by user activating a switch. In the passive mode the disarm/unlock command is automatically sent by the transmitter without the user having to activate any switches on the transmitter. The transmitter is configured to switch from the passive mode to the active mode in response to at least one of a user activated signal or a battery threshold signal.

Abstract: Stabilized flame retardant polymer compositions containing a hydrated metal compound, e.g., a metal hydroxide, as a flame retardant, when added an effective stabilizing amount of an amine oxide, a hydroxyl amine or mixtures thereof, exhibit desirable physical characteristics of pure polymers due to the stabilizer additives, including excellent color stability, while attaining desirable fire-retardance standards.

Abstract: The disclosed device is an additional, normally-closed relay positioned in line with the ignition switch and the functionality controlled by the OEM, normally-open relay. When the aftermarket system is in the disarmed state, the normally-closed relay is dormant in its closed position, thereby allowing the circuit to complete its intended loop. When the aftermarket security system is enabled, the normally-closed relay will open the current flow and prevent the current from reaching its target, thereby disrupting or disabling the operation of the vehicle function. If the normally-closed relay fails, it fails in its closed position, thereby not affecting the OEM system.

Abstract: A process for the preparation of a neo diol phosphite stabilizer by a direct/solvent-less method, wherein a neoalkyl chlorophosphite is reacted directly with a mono- or di-substituted hydroxylated aromatic compound, for neo diol phosphite product having little or no odor is provided. Also provided are polymeric compositions comprising a stabilizing amount of a neo diol phosphite having low to no odor.

Abstract: There is disclosed herein a single use syringe (1) having a container section (2), a valve section (4) and a hollow needle (4a). The valve section (4) contains a one-way valve (40) which allows fluid to flow in only one direction through the valve section (4). The single use syringe (1) may also be provided with locking means to prevent the separation of the container section (2) from the valve section (4). There is also disclosed herein packaging (16, 17) and a carry case (10, 11) in which to store and transport the single use syringe (1).