Patents by Inventor Marshall Morningstar
Marshall Morningstar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11866441Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: GrantFiled: July 28, 2021Date of Patent: January 9, 2024Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
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Publication number: 20230055237Abstract: The invention relates to a compound of Formula I, pharmaceutical compositions comprising a compound of Formula I, and pharmaceutically acceptable slats thereof, pharmaceutical compositions comprising such compounds and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula Ito a subject in need thereof.Type: ApplicationFiled: July 23, 2021Publication date: February 23, 2023Inventors: Michael P. Zawistoski, Christopher Oalmann, Feng Li, Andrew Kolodziej, Marshall Morningstar
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Publication number: 20220162211Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: ApplicationFiled: July 28, 2021Publication date: May 26, 2022Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Publication number: 20220033404Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.Type: ApplicationFiled: September 18, 2019Publication date: February 3, 2022Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: L. DAVID SIBLEY, JOSHUA RADKE, EAMON COMER, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Patent number: 11174260Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: GrantFiled: March 20, 2018Date of Patent: November 16, 2021Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
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Publication number: 20200095253Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: ApplicationFiled: March 20, 2018Publication date: March 26, 2020Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Publication number: 20120108577Abstract: The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.Type: ApplicationFiled: January 11, 2012Publication date: May 3, 2012Applicant: ASTRAZENECA ABInventors: Gloria Breault, Charles Joseph Eyermann, Bolin Geng, Marshall Morningstar, Folkert Reck
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Patent number: 8124602Abstract: The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds of Formula V(A) useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.Type: GrantFiled: December 9, 2010Date of Patent: February 28, 2012Assignee: AstraZeneca ABInventors: Gloria Breault, Charles Joseph Eyermann, Bolin Geng, Marshall Morningstar, Folkert Reck
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Publication number: 20110092495Abstract: The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.Type: ApplicationFiled: December 9, 2010Publication date: April 21, 2011Applicant: ASTRAZENECA ABInventors: Gloria Breault, Charles Joseph Eyermann, Bolin Geng, Marshall Morningstar, Folkert Reck
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Patent number: 7875715Abstract: The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.Type: GrantFiled: June 16, 2006Date of Patent: January 25, 2011Assignee: AstraZeneca ABInventors: Gloria Breault, Charles Joseph Eyermann, Bolin Geng, Marshall Morningstar, Folkert Reck
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Publication number: 20100152441Abstract: The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.Type: ApplicationFiled: June 16, 2006Publication date: June 17, 2010Applicant: ASTRAZENECA ABInventors: Gloria Breault, Charles Joseph Eyermann, Bolin Geng, Marshall Morningstar, Folkert Reck
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Publication number: 20090131444Abstract: The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans.Type: ApplicationFiled: May 23, 2006Publication date: May 21, 2009Applicant: ASTRAZENECA ABInventors: Folkert Reck, Marshall Morningstar, Hajnalka Hartl
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Publication number: 20090062236Abstract: The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.Type: ApplicationFiled: January 29, 2007Publication date: March 5, 2009Applicant: Massachusetts Institute of TechnologyInventors: John M. Essigmann, Robert G. Croy, Kevin J. Yarema, Marshall Morningstar
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Patent number: 7375128Abstract: The present invention relates to a compound of formula (I): wherein R is hydrogen atom, hydroxyl group or carbamoyl group, and n is 1 or 2, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 6, 2003Date of Patent: May 20, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Ila Sircar, Marshall Morningstar, Masatoshi Kakushima, Hidefumi Kaji, Takayuki Kawaguchi, Toshiyuki Kume
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Patent number: 7371757Abstract: This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.Type: GrantFiled: August 12, 2004Date of Patent: May 13, 2008Assignee: AstraZeneca ABInventors: Marshall Morningstar, Gregory Basarab, Charles Joseph Eyermann, Madhu Gowravaram, Oluyinka Green, Andrew Kiely, Lawrence MacPherson, Nguyen Thanh
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Patent number: 7342012Abstract: The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating ?L?2 adhesion mediated conditions in a mammal.Type: GrantFiled: March 3, 2005Date of Patent: March 11, 2008Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Ila Sircar, Paul Furth, Bradley R. Teegarden, Marshall Morningstar, Nicholas Smith, Ronald C. Griffith
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Publication number: 20070275954Abstract: This invention relates to novel compounds having the Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.Type: ApplicationFiled: May 19, 2005Publication date: November 29, 2007Applicant: AstraZeneca ABInventors: Gregory Basarab, Charles Eyermann, Bolin Geng, Madhusudhan Gowravaram, James Loch III, Lawrence MacPherson, Marshall Morningstar, George Mullen, Alex Staz, Andrew Kiely
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Patent number: 7285558Abstract: Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection.Type: GrantFiled: June 28, 2002Date of Patent: October 23, 2007Assignee: AstraZeneca ABInventors: Gregory Basarab, Joseph Eyermann, Madhusudhan Gowravaram, Oluyinka Green, Lawrence MacPherson, Marshall Morningstar, Thanh Nguyen
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Patent number: 7169611Abstract: The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.Type: GrantFiled: November 18, 2002Date of Patent: January 30, 2007Assignee: Massachusetts Institute of TechnologyInventors: John M. Essigmann, Robert G. Croy, Kevin J. Yarema, Marshall Morningstar
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Publication number: 20070004761Abstract: This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.Type: ApplicationFiled: December 19, 2003Publication date: January 4, 2007Inventors: Gregory Basarab, Joseph Eyermann, Madhusudhan Gowravaram, Ohryinka Green, Lawrence MacPherson, Marshall Morningstar, Thanh Nguyen